Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in Autism

自闭症患者的睡眠和昼夜节律障碍、大脑和神经行为发育

• 批准号: 10450073
• 负责人: Stewart H Mostofsky
• 金额: $ 29.26万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10450073
• 关键词: 12 year old; Acute; Adaptive Behaviors; Address; Adult; Affect; Area; Attention; Base of the Brain; Behavior; Behavioral; Biological; Biological Markers; Biometry; Brain; Child; Circadian Dysregulation; Clinical; Cognition; Cognitive; Data; Detection; Development; Developmental Disabilities; Diagnosis; Elements; Enrollment; Epidemiology; Etiology; Exhibits; Goals; Health behavior; Hour; Impairment; Institutes; Intellectual and Developmental Disabilities Research Centers; Intervention; Link; Literature; Machine Learning; Measurement; Measures; Mediating; Methodology; Methods; Modeling; Motor Activity; Outcome; Outcome Measure; Parents; Pattern; Phase; Phenotype; Population; Precision therapeutics; Preparation; Prevention; Procedures; Questionnaires; Reporting; Research; Research Project Grants; Resources; Rest; Role; Sample Size; Sampling; School-Age Population; Severities; Sleep; Sleep Disorders; Sleep disturbances; Statistical Models; Structure; Symptoms; Thick; Time; Universities; Work; Wrist; Youth; actigraphy; analytical method; autism spectrum disorder; autistic; autistic children; base; behavioral phenotyping; brain health; circadian; executive function; improved; improved outcome; indexing; innovation; innovative technologies; neurobehavioral; neuroimaging; novel; personalized intervention; poor sleep; sleep behavior; sleep onset; social; trait

PROJECT SUMMARY/ABSTRACT – RESEARCH COMPONENT The goal of this study entitled, “Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in Autism” is to examine how disturbed sleep and altered circadian rest/activity rhythms (RARs) affect brain development, cognitive and adaptive function, and symptom severity in children with autism. Disturbed sleep is highly prevalent among children with autism spectrum disorder (ASD); over 60% are estimated to exhibit frequent sleep disturbances, including delayed sleep onset, fragmented nighttime sleep, and early-morning waking. While typically viewed as a consequence of ASD, disturbed sleep may not only have acute effects on cognition, adaptive functioning, and behavioral disturbances in this population. Notably, while many studies have evaluated the relationship between disordered sleep and neuroimaging, and neuroimaging and ASD, no work, to our knowledge, has integrated these topics. Furthermore, rigorous comparison of sleep and RAR metrics via parent-report and actigraphy have not been conducted in ASD. For this project, we propose to address these gaps through refining how sleep/wake problems are assessed in children with ASD by applying novel statistical modeling to both objective (using actigraphy) and parent-report (using CSHQ) measures and examining how disturbed sleep and altered RARs might affect brain structure and function in children with ASD. We embed this project in the Kennedy Krieger Institute-Johns Hopkins University Intellectual and Developmental Disabilities Research Center (IDDRC), leveraging crucial resources in phenotypic assessment, neuroimaging, biostatistics, and behavioral preparation for procedures that are available through the Center. At the same time, this investigative team brings new statistical and epidemiologic expertise to Center Cores, to conduct this study in 200 children with and without ASD. Via this project, Center resources will be used to further integrate this population with 493 children with extant data (but not wrist actigraphy), establishing a large-well phenotyped population for Center research. This work will help to refine and inform clinical and prevention practices among children with disordered sleep and ASD, providing methodological advances in sleep characterization and etiology.

项目摘要/摘要 - 研究部分 这项研究的目标是“睡眠和昼夜节律功能障碍、大脑和神经行为发育” “自闭症”的目的是研究睡眠障碍和昼夜节律休息/活动节律（RAR）如何影响大脑 自闭症儿童的发育、认知和适应功能以及症状严重程度。睡眠不安 在患有自闭症谱系障碍 (ASD) 的儿童中非常普遍；估计超过60%将展出 频繁的睡眠障碍，包括入睡延迟、夜间睡眠碎片化和清晨 醒来。虽然睡眠障碍通常被视为自闭症谱系障碍（ASD）的后果，但它可能不仅对身体产生严重影响 该人群的认知、适应性功能和行为障碍。值得注意的是，虽然许多研究 评估了睡眠障碍与神经影像学之间的关系，以及神经影像学与 ASD 之间的关系，没有 据我们所知，工作已经整合了这些主题。此外，睡眠和 RAR 的严​​格比较 通过家长报告和体动记录仪进行的测量尚未在 ASD 中进行。 对于这个项目，我们建议通过改进睡眠/觉醒问题的解决方式来解决这些差距 通过将新颖的统计模型应用于客观（使用体动记录仪）和 家长报告（使用 CSHQ）测量并检查睡眠障碍和 RAR 改变如何影响大脑 ASD 儿童的结构和功能。我们将此项目嵌入肯尼迪克里格研究所-约翰斯 霍普金斯大学智力与发育障碍研究中心 (IDDRC)，利用关键的 表型评估、神经影像、生物统计学和手术行为准备方面的资源 可通过中心获取。与此同时，这个调查小组带来了新的统计数据和 Center Cores 的流行病学专业知识对 200 名患有和不患有自闭症谱系障碍 (ASD) 的儿童进行了这项研究。通过这个 项目中，中心资源将用于进一步整合这一人口与现有数据的 493 名儿童（但 不是手腕体动记录仪），为中心研究建立了一个大型的表型群体。这项工作将有助于 完善睡眠障碍和自闭症谱系障碍儿童的临床和预防实践并为其提供信息，提供 睡眠特征和病因学的方法学进展。