NEUROIMAGING CORE

A.目标 核心C活动的重点是使用神经成像技术，特别是功能磁 磁共振成像（fMRI）和扩散张量成像（DTI），以评估神经相关的重要 在单字阅读和句子理解两个层面上，对阅读能力都有贡献; 前者不仅包括阅读单个单词的能力，还包括学习新的语音语义 联想，对阅读的发展至关重要。通过使用fMRI和DTI，我们将能够检查 大脑区域的功能，有助于这些重要方面的阅读能力，以及如何 这些区域之间连接的完整性影响阅读能力。一个重要的长期目标将是 将这些方法联合收割机结合起来，这样我们就可以检查区域之间联系的完整性 在功能性磁共振成像上被确定为与阅读功能相关（包括SWR和理解）。如其他 在本申请的第二部分中，核心C下要分析的主题包括三个主题中所包括的主题。 本中心资助的四个项目。因此，核心C将在该中心赠款中发挥核心作用， 神经影像学研究工作与PPG的其他组成部分（见下文给药部分）。

A. OBJECTIVES Core C activities are focused on using neuroimaging techniques, specifically functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI), to assess the neural correlates of important contributors to reading ability at both the single-word reading (SWR) and sentence comprehension levels; the former will not only include the ability to read single words, but to also learn new phonemic-semantic associations, critical to the development of reading. By using both fMRI and DTI, we will be able to examine the function of brain regions that contribute to these important aspects of reading ability, as well as how the integrity of the connections between these regions impacts reading ability. An important long-term goal will be to combine these approaches so that we can examine the integrity of connections between regions determined, on fMRI, to be functionally relevant to reading (both SWR and comprehension). As stated in other sections of this application, the subjects to be analyzed under Core C comprise those included in three of the four projects of this center grant. Thus, Core C will play a central role in this center grant by coordinating neuroimaging research efforts with other components of the PPG (see Administration section below).