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NEUROIMAGING CORE

神经影像核心

基本信息

批准号：
7699902
负责人：
Stewart H Mostofsky
金额：
$ 17.95万
依托单位：
HUGO W. MOSER RES INST KENNEDY KRIEGER
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-08-01 至 2011-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7699902
关键词：
Brain region Comprehension Development Diffusion Magnetic Resonance Imaging Functional Magnetic Resonance Imaging Goals Grant Image Learning Play Reading Research Role Semantics Techniques neuroimaging relating to nervous system

项目摘要

A. OBJECTIVES Core C activities are focused on using neuroimaging techniques, specifically functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI), to assess the neural correlates of important contributors to reading ability at both the single-word reading (SWR) and sentence comprehension levels; the former will not only include the ability to read single words, but to also learn new phonemic-semantic associations, critical to the development of reading. By using both fMRI and DTI, we will be able to examine the function of brain regions that contribute to these important aspects of reading ability, as well as how the integrity of the connections between these regions impacts reading ability. An important long-term goal will be to combine these approaches so that we can examine the integrity of connections between regions determined, on fMRI, to be functionally relevant to reading (both SWR and comprehension). As stated in other sections of this application, the subjects to be analyzed under Core C comprise those included in three of the four projects of this center grant. Thus, Core C will play a central role in this center grant by coordinating neuroimaging research efforts with other components of the PPG (see Administration section below).

A.目标核心C活动的重点是使用神经成像技术，特别是功能磁学磁共振成像(FMRI)和扩散张量成像(DTI)，以评估重要的神经相关性在单词阅读(SWR)和句子理解水平上对阅读能力的贡献；前者不仅包括阅读单个单词的能力，而且还包括学习新的音素-语义的能力联想，对阅读的发展至关重要。通过同时使用功能磁共振成像和DTI，我们将能够检查影响阅读能力的这些重要方面的大脑区域的功能，以及这些区域之间联系的完整性会影响阅读能力。一个重要的长期目标将是将这些方法组合在一起，以便我们可以检查区域之间连接的完整性在功能磁共振成像上，被确定为与阅读(SWR和理解)有关的功能。如其他文件中所述本申请的部分，核心C下要分析的主题包括以下三个部分该中心资助的四个项目。因此，核心C将通过协调在该中心赠款中扮演中心角色与PPG的其他组件一起进行神经成像研究(参见下面的管理部分)。