NEUROIMAGING CORE

神经影像核心

• 批准号: 7699902
• 负责人: Stewart H Mostofsky
• 金额: $ 17.95万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7699902
• 关键词: Brain region; Comprehension; Development; Diffusion Magnetic Resonance Imaging; Functional Magnetic Resonance Imaging; Goals; Grant; Image; Learning; Play; Reading; Research; Role; Semantics; Techniques; neuroimaging; relating to nervous system

A. OBJECTIVES Core C activities are focused on using neuroimaging techniques, specifically functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI), to assess the neural correlates of important contributors to reading ability at both the single-word reading (SWR) and sentence comprehension levels; the former will not only include the ability to read single words, but to also learn new phonemic-semantic associations, critical to the development of reading. By using both fMRI and DTI, we will be able to examine the function of brain regions that contribute to these important aspects of reading ability, as well as how the integrity of the connections between these regions impacts reading ability. An important long-term goal will be to combine these approaches so that we can examine the integrity of connections between regions determined, on fMRI, to be functionally relevant to reading (both SWR and comprehension). As stated in other sections of this application, the subjects to be analyzed under Core C comprise those included in three of the four projects of this center grant. Thus, Core C will play a central role in this center grant by coordinating neuroimaging research efforts with other components of the PPG (see Administration section below).

A.目标 核心C活动的重点是使用神经影像技术，特别是功能性磁性 共振成像（fMRI）和扩散张量成像（DTI），以评估重要的神经相关性 单词阅读（SWR）和句子理解水平的阅读能力的贡献者；这 前者不仅包括阅读单词的能力，而且还包括学习新的语音语义 协会，对阅读的发展至关重要。通过使用fMRI和DTI，我们将能够检查 大脑区域的功能有助于阅读能力的这些重要方面以及如何 这些区域之间的联系的完整性会影响阅读能力。一个重要的长期目标是 结合这些方法，以便我们可以研究区域之间的连接的完整性 在fMRI上确定与阅读功能（SWR和理解）具有功能相关。如其他 该应用程序的部分，要根据核心C进行分析的受试者构成了三个中包含的受试者 该中心赠款的四个项目。因此，核心C通过协调将在该中心赠款中发挥核心作用 与PPG的其他组成部分的神经影像学研究（请参见下面的管理部分）。