Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in Autism

自闭症患者的睡眠和昼夜节律障碍、大脑和神经行为发育

• 批准号: 10085599
• 负责人: Stewart H Mostofsky
• 金额: $ 28.87万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10085599
• 关键词: 12 year old; Acute; Adaptive Behaviors; Address; Adult; Affect; Area; Attention; Base of the Brain; Behavior; Behavioral; Biological; Biological Markers; Biometry; Brain; Child; Circadian Dysregulation; Clinical; Cognition; Cognitive; Data; Detection; Development; Developmental Disabilities; Diagnosis; Elements; Enrollment; Epidemiology; Etiology; Exhibits; Goals; Health behavior; Hour; Impairment; Institutes; Intellectual and Developmental Disabilities Research Centers; Intervention; Link; Literature; Machine Learning; Measurement; Measures; Mediating; Methodology; Methods; Modeling; Motor Activity; Outcome; Outcome Measure; Parents; Pattern; Phase; Phenotype; Population; Precision therapeutics; Preparation; Prevention; Procedures; Questionnaires; Reporting; Research; Research Project Grants; Resources; Rest; Role; Sample Size; Sampling; School-Age Population; Severities; Sleep; Sleep Disorders; Sleep disturbances; Statistical Models; Structure; Symptoms; Thick; Time; Universities; Work; Wrist; Youth; actigraphy; analytical method; autism spectrum disorder; autistic; autistic children; base; behavioral phenotyping; brain health; circadian; executive function; improved; improved outcome; indexing; innovation; innovative technologies; neurobehavioral; neuroimaging; novel; personalized intervention; sleep behavior; sleep onset; social; trait

PROJECT SUMMARY/ABSTRACT – RESEARCH COMPONENT The goal of this study entitled, “Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in Autism” is to examine how disturbed sleep and altered circadian rest/activity rhythms (RARs) affect brain development, cognitive and adaptive function, and symptom severity in children with autism. Disturbed sleep is highly prevalent among children with autism spectrum disorder (ASD); over 60% are estimated to exhibit frequent sleep disturbances, including delayed sleep onset, fragmented nighttime sleep, and early-morning waking. While typically viewed as a consequence of ASD, disturbed sleep may not only have acute effects on cognition, adaptive functioning, and behavioral disturbances in this population. Notably, while many studies have evaluated the relationship between disordered sleep and neuroimaging, and neuroimaging and ASD, no work, to our knowledge, has integrated these topics. Furthermore, rigorous comparison of sleep and RAR metrics via parent-report and actigraphy have not been conducted in ASD. For this project, we propose to address these gaps through refining how sleep/wake problems are assessed in children with ASD by applying novel statistical modeling to both objective (using actigraphy) and parent-report (using CSHQ) measures and examining how disturbed sleep and altered RARs might affect brain structure and function in children with ASD. We embed this project in the Kennedy Krieger Institute-Johns Hopkins University Intellectual and Developmental Disabilities Research Center (IDDRC), leveraging crucial resources in phenotypic assessment, neuroimaging, biostatistics, and behavioral preparation for procedures that are available through the Center. At the same time, this investigative team brings new statistical and epidemiologic expertise to Center Cores, to conduct this study in 200 children with and without ASD. Via this project, Center resources will be used to further integrate this population with 493 children with extant data (but not wrist actigraphy), establishing a large-well phenotyped population for Center research. This work will help to refine and inform clinical and prevention practices among children with disordered sleep and ASD, providing methodological advances in sleep characterization and etiology.

项目摘要/摘要-研究部分