Movement-Based Training for Children with ADHD: A Feasibility Study

描述（由申请人提供）：注意缺陷多动障碍（ADHD）是儿童时期最常见的行为诊断。它会导致高昂的医疗费用，并可能导致学业成绩不佳，成人精神疾病，药物滥用和犯罪行为。标准治疗，如刺激性药物，主要针对症状，以及对ADHD治疗儿童的长期随访研究表明，与典型发育（TD）同龄人相比，他们的结果仍然显着更差。因此，行为训练计划有巨大的潜在公共卫生效益，可以补救ADHD的核心特征。为此，值得考虑的是长期观察，ADHD儿童经常表现出运动控制困难，包括运动不持久和无法抑制运动溢出，这与高阶行为控制措施平行（并相关）。此外，最近的功能成像和经颅磁刺激（TMS）研究结果显示，ADHD儿童表现出异常招募皮层抑制机制，这些运动抑制解除的生理措施与父母对儿童ADHD症状的评级密切相关。鉴于这些研究结果，因此，旨在通过运动系统的参与来改善行为控制的基于运动的干预措施为针对ADHD的特定生物底物提供了一种有前途的方法。认知和行为控制的增益已被观察到使用正念运动训练，包括本应用程序的重点：太极。尽管与老年人相比，在儿童中观察到的大脑可塑性明显更大，但正念运动训练的儿科应用一直未得到充分利用和研究。针对这一差距，我们建议研究基于运动的太极拳训练对ADHD儿童的疗效。考虑到在正念和运动训练研究中对生理生物标志物的需求，除了评估核心ADHD症状外，我们还将跟踪特定运动行为和生理（来自TMS）标志物的变化。我们提出的设计采用了“快速失败模型”，以建立可行性进展到临床试验的疗效太极拳，并可能其他形式的正念运动训练，为儿童多动症。在R21阶段，患有ADHD的儿童将进行为期8周的太极训练，训练前和训练后通过TMS和行为测试测量运动系统功能。还将收集学生和家长经验的定性措施，以补充核心运动系统目标的数据。在完成项目里程碑后，R33阶段将纳入ADHD症状严重程度的测量，以及认知控制的研究领域标准（RDoC）测量。此外，R33阶段将包括训练中期（除了训练前和训练后）评估，我们将调查运动系统测量的变化将先于ADHD症状严重程度变化的假设。这项研究为开发新的ADHD治疗方法提供了巨大的潜力，而且不良反应的风险很小。

DESCRIPTION (provided by applicant): Attention Deficit Hyperactivity Disorder (ADHD) is the most common behavioral diagnosis in childhood. It incurs high medical costs, and can contribute to poor academic achievement, adult mental illness, substance abuse, and criminal behavior. Standard treatments, such as stimulant medications, primarily target symptoms, and long-term follow-up studies of children treated for ADHD reveal that their outcomes remain significantly worse as compared to typically developing (TD) peers. Thus, there are tremendous potential public health benefits for behavioral training programs that could remediate core features of ADHD. To this end, it is worth considering the long-standing observation that children with ADHD often demonstrate difficulties with motor control, including motor impersistence and failure to inhibit motor overflow, that parallel (and correlate with) difficultie with measures of higher-order behavioral control. Further, recent functional imaging and transcranial magnetic stimulation (TMS) findings reveal children with ADHD show abnormal recruitment of cortical inhibitory mechanisms, and that these physiologic measures of motor disinhibition robustly correlate with parent ratings of children's ADHD symptoms. Given these findings, it follows that movement-based interventions that aim to achieve improved behavioral control through engagement of the motor system offer a promising approach for targeting specific biological substrates of ADHD. Gains in cognitive and behavioral control have been observed using mindful movement training, including the focus of this application: Tai Chi. Despite the markedly greater brain plasticity observed in children as compared to older adults, pediatric applications of mindful movement training has been under utilized and under investigated. Addressing this gap, we propose to examine the efficacy of a movement-based Tai Chi training for children with ADHD. Given the recognized need for physiologic biomarkers in mindfulness and movement training studies, we will track changes in specific motor behavioral and physiologic (from TMS) markers, in addition to assessment of core ADHD symptoms. Our proposed design employs a "Fast Fail Model" to establish feasibility for progression to a clinical trial of efficacy for Tai Chi, and potentially other forms of mindful movement training, for childrn with ADHD. In the R21 phase, children with ADHD will engage in an 8-week Tai Chi training, with pre- and post-training measurement of motor system function via TMS and behavioral testing. Qualitative measures of student and parent experience will also be collected to complement data on core motor system targets. Upon completion of project milestones, the R33 phase will incorporate measures of ADHD symptom severity, as well as Research Domain Criteria (RDoC) measures of cognitive control. Further, the R33 phase will include a mid-training (in addition to pre- and post-training) assessment and we will investigate the hypothesis that changes in motor system measures will precede changes in ADHD symptom severity. The proposed study offers immense potential for the development of novel therapeutic approaches for ADHD with little risk of adverse reaction.