Enhancing Social Competence in Adults with Autism Spectrum Disorder: A Pilot RCT

增强自闭症谱系障碍成人的社交能力：试点随机对照试验

• 批准号: 10133151
• 负责人: Blythe Anne Corbett
• 金额: $ 49.62万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10133151
• 关键词: Address; Adolescent; Adult; Age; Age-Years; Anxiety; Area; Awareness; Behavioral; Centers for Disease Control and Prevention (U.S.); Child; Clinical; Cognitive; Communities; Community Services; Control Groups; Data Collection; Development; Diagnosis; Effectiveness; Emotional; Employment; Enrollment; Evaluation; Event-Related Potentials; Face; Failure; Foundational Skills; Goals; Growth; Hour; Impairment; Intervention; Left; Link; Maintenance; Manuals; Measures; Mediating; Memory; Mental Depression; Modification; Moods; Motivation; Neurodevelopmental Disorder; Neuropsychology; Outcome; Participant; Performance; Play; Randomized; Research; Service delivery model; Services; Social Behavior; Social Functioning; Social Interaction; Stress; Symptoms; Techniques; Testing; Training; Waiting Lists; Youth; adolescent with autism spectrum disorder; adult with autism spectrum disorder; autism spectrum disorder; base; behavioral outcome; blind; care costs; clinical efficacy; cohort; community based treatment; community engagement; control trial; evidence base; experience; experimental group; follow-up; functional outcomes; improved; individuals with autism spectrum disorder; informant; innovation; neuroimaging; novel; peer; programs; psychosocial; psychosocial development; rehearsal; relating to nervous system; skills; social; social cognition; social communication; social deficits; social engagement; social relationships; social skills; supportive environment; treatment effect; young adult; young adult with autism spectrum disorder

PROJECT SUMMARY Autism spectrum disorder (ASD) is characterized by primary impairment in social competence. Current psychosocial interventions for adults with ASD are lacking and urgently needed. The goal of the current proposal is to address this critical, unmet need for the development of psychosocial interventions for adults with ASD by utilizing an innovative intervention with emerging efficacy in children and adolescents with ASD. SENSE Theatre combines established behavioral techniques alongside theatrical strategies delivered in a peer- mediated, community service model with strong evidence of significant improvement in social competence. Recent findings from a randomized control trial (RCT) in youth with ASD show immediate between-group effects and evidence of target engagement on the hypothesized mechanism of action, social salience (e.g., memory for faces), evaluated by event-related potentials (ERP) and neuropsychological measures, which were linked to improvement in social interaction, social communication and adaptive functioning. While previous research has been efficacious, the objective of the application is to determine if SENSE Theatre is effective for adults with ASD at impacting social cognition, which in turn results in changes in functional clinical outcomes for adults with ASD. The proposal will develop and conduct a pilot RCT on an existing and novel psychosocial intervention explicitly tailored for adults with ASD. The intervention consists of 10 weekly sessions, 3 hours per session as well as dress/technical rehearsal and two public performances. Modifications to the current SENSE Theatre program will include: 1) having trained adult peers, 2) more age-appropriate theatrical play themes and individualized monologues (e.g., social relationships, employment), and 3) individualized character development and performance goals. The study will enroll 40 participants with high-functioning ASD 18 to 35 years of age randomized to experimental (EXP = 20) and waitlist control (WLC = 20) groups. The proposed RCT aims to: 1) assess target engagement of memory for faces, a foundational skill for social competence, using neuroimaging (ERP) and neuropsychological measures, and 2) test the link between the degree of target engagement of face memory and functional outcomes (e.g., social skills, and social interaction with novel peers). Measures will be assessed at pretest, posttest, and 2-month follow-up. The project will help achieve the goal to inform, refine and finalize a SENSE Theatre manual for adults with ASD. If predicted results occur, it will provide strong empirical support for a psychosocial intervention that has generalized and maintained effects on social competence that left untreated has significant consequences for adults with ASD.

项目概要 自闭症谱系障碍 (ASD) 的特点是社交能力的主要障碍。当前的 针对自闭症谱系障碍成人的心理社会干预措施尚缺乏且迫切需要。当前提案的目标 的目的是解决为患有自闭症谱系障碍（ASD）的成人制定心理社会干预措施这一关键的、未得到满足的需求 利用对患有自闭症谱系障碍（ASD）的儿童和青少年产生新功效的创新干预措施。感觉 戏剧将既定的行为技术与在同行中提供的戏剧策略相结合。 中介的社区服务模式，有强有力的证据表明社交能力显着提高。 一项针对患有自闭症谱系障碍 (ASD) 青少年的随机对照试验 (RCT) 的最新结果显示了组间的直接影响 以及对假设的行动机制、社会显着性（例如记忆）的目标参与的证据 面部），通过事件相关电位（ERP）和神经心理学测量进行评估，这些测量与 改善社会互动、社会沟通和适应功能。虽然之前的研究已经 是否有效，该应用程序的目的是确定 SENSE Theatre™ 对患有以下疾病的成年人是否有效： 自闭症谱系障碍会影响社会认知，进而导致患有自闭症谱系障碍的成年人的功能性临床结果发生变化 自闭症谱系障碍。该提案将针对现有的和新型的心理社会干预措施制定并开展试点随机对照试验 专为患有自闭症谱系障碍 (ASD) 的成年人量身定制。干预包括 10 周一次，每次 3 小时 以及服装/技术排练和两次公开表演。对当前 SENSE 剧院的修改 计划将包括：1）训练有素的成年同伴，2）更适合年龄的戏剧主题和 个性化的独白（例如，社会关系、就业），以及3）个性化的性格 发展和绩效目标。该研究将招募 40 名 18 至 35 岁患有高功能 ASD 的参与者 年龄随机分为实验组 (EXP = 20) 和候补对照组 (WLC = 20)。拟议的随机对照试验 旨在：1）评估面部记忆的目标参与度，这是社交能力的基本技能，使用 神经影像学 (ERP) 和神经心理学测量，2) 测试目标程度之间的联系 面部记忆和功能结果的参与（例如，社交技能以及与新同伴的社交互动）。 将在预测试、后测试和 2 个月的随访中对措施进行评估。该项目将有助于实现目标 为患有 ASD 的成人提供信息、完善和最终确定 SENSE Theater 手册。如果预测的结果发生，将会 为社会心理干预提供强有力的实证支持，该干预措施具有普遍性和持续性的影响 如果不加以治疗，社交能力会给患有自闭症谱系障碍的成年人带来严重后果。