Enhancing Social Competence in Adults with Autism Spectrum Disorder: A Pilot RCT

增强自闭症谱系障碍成人的社交能力：试点随机对照试验

• 批准号: 10133151
• 负责人: Blythe Anne Corbett
• 金额: $ 49.62万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10133151
• 关键词: Address; Adolescent; Adult; Age; Age-Years; Anxiety; Area; Awareness; Behavioral; Centers for Disease Control and Prevention (U.S.); Child; Clinical; Cognitive; Communities; Community Services; Control Groups; Data Collection; Development; Diagnosis; Effectiveness; Emotional; Employment; Enrollment; Evaluation; Event-Related Potentials; Face; Failure; Foundational Skills; Goals; Growth; Hour; Impairment; Intervention; Left; Link; Maintenance; Manuals; Measures; Mediating; Memory; Mental Depression; Modification; Moods; Motivation; Neurodevelopmental Disorder; Neuropsychology; Outcome; Participant; Performance; Play; Randomized; Research; Service delivery model; Services; Social Behavior; Social Functioning; Social Interaction; Stress; Symptoms; Techniques; Testing; Training; Waiting Lists; Youth; adolescent with autism spectrum disorder; adult with autism spectrum disorder; autism spectrum disorder; base; behavioral outcome; blind; care costs; clinical efficacy; cohort; community based treatment; community engagement; control trial; evidence base; experience; experimental group; follow-up; functional outcomes; improved; individuals with autism spectrum disorder; informant; innovation; neuroimaging; novel; peer; programs; psychosocial; psychosocial development; rehearsal; relating to nervous system; skills; social; social cognition; social communication; social deficits; social engagement; social relationships; social skills; supportive environment; treatment effect; young adult; young adult with autism spectrum disorder

PROJECT SUMMARY Autism spectrum disorder (ASD) is characterized by primary impairment in social competence. Current psychosocial interventions for adults with ASD are lacking and urgently needed. The goal of the current proposal is to address this critical, unmet need for the development of psychosocial interventions for adults with ASD by utilizing an innovative intervention with emerging efficacy in children and adolescents with ASD. SENSE Theatre combines established behavioral techniques alongside theatrical strategies delivered in a peer- mediated, community service model with strong evidence of significant improvement in social competence. Recent findings from a randomized control trial (RCT) in youth with ASD show immediate between-group effects and evidence of target engagement on the hypothesized mechanism of action, social salience (e.g., memory for faces), evaluated by event-related potentials (ERP) and neuropsychological measures, which were linked to improvement in social interaction, social communication and adaptive functioning. While previous research has been efficacious, the objective of the application is to determine if SENSE Theatre is effective for adults with ASD at impacting social cognition, which in turn results in changes in functional clinical outcomes for adults with ASD. The proposal will develop and conduct a pilot RCT on an existing and novel psychosocial intervention explicitly tailored for adults with ASD. The intervention consists of 10 weekly sessions, 3 hours per session as well as dress/technical rehearsal and two public performances. Modifications to the current SENSE Theatre program will include: 1) having trained adult peers, 2) more age-appropriate theatrical play themes and individualized monologues (e.g., social relationships, employment), and 3) individualized character development and performance goals. The study will enroll 40 participants with high-functioning ASD 18 to 35 years of age randomized to experimental (EXP = 20) and waitlist control (WLC = 20) groups. The proposed RCT aims to: 1) assess target engagement of memory for faces, a foundational skill for social competence, using neuroimaging (ERP) and neuropsychological measures, and 2) test the link between the degree of target engagement of face memory and functional outcomes (e.g., social skills, and social interaction with novel peers). Measures will be assessed at pretest, posttest, and 2-month follow-up. The project will help achieve the goal to inform, refine and finalize a SENSE Theatre manual for adults with ASD. If predicted results occur, it will provide strong empirical support for a psychosocial intervention that has generalized and maintained effects on social competence that left untreated has significant consequences for adults with ASD.

项目摘要 自闭症谱系障碍（ASD）的特征是社会能力的主要障碍。当前的 缺乏对ASD成年人的社会心理干预措施，迫切需要。当前建议的目标 是解决这种至关重要的，未满足的需求，以开发为患有ASD的成年人的心理心理干预措施 使用ASD的儿童和青少年进行创新的干预效率。感觉 戏剧将既定的行为技术与同行中交付的戏剧策略结合在一起 介导的社区服务模型，有强有力的社会能力改善的证据。 ASD年轻人的一项随机对照试验（RCT）的最新发现立即显示组间影响 以及针对假设的行动机制，社会显着性机理的证据（例如，记忆 面对面），通过事件相关电位（ERP）和神经心理学措施进行评估，这些措施与 社交互动，社会交流和适应性功能的改善。虽然以前的研究已经 效率很高，该应用的目的是确定SenseTheatre是否对成年人有效 ASD影响社会认知，这又导致成年人功能临床结果的变化 ASD。该提案将对现有和新颖的社会心理干预措施开发并进行飞行员RCT 明确针对患有ASD的成年人量身定制。干预措施包括10个每周课程，每节3小时 以及着装/技术彩排和两次公开表演。修改当前的剧院 计划包括：1）接受训练的成人同伴，2）更多适合年龄的戏剧主题和 个性化的独白（例如，社会关系，就业）和3）个性化性格 发展和绩效目标。该研究将招募40名参与者，具有高功能ASD 18至35 年龄随机分为实验（EXP = 20）和候补控制（WLC = 20）组。拟议的RCT 目的是：1）评估对面孔记忆的目标参与，这是社会能力的基础技能，使用 神经影像学（ERP）和神经心理学措施，2）测试目标程度之间的联系 面对记忆和功能结果的参与（例如，社交技能和与新颖同伴的社交互动）。 措施将在预测试，后测和2个月的随访中进行评估。该项目将有助于实现目标 告知，完善和最终确定ASD成人的感觉剧院手册。如果发生预测的结果，它将 为心理社会干预提供了强有力的经验支持，该干预对 未经治疗的社会能力对ASD的成年人产生了重大影响。