Psychobiological investigation of the socioemotional functioning in autism

自闭症社会情绪功能的心理生物学调查

基本信息

批准号：
8645740
负责人：
Blythe Anne Corbett
金额：
$ 34.75万
依托单位：
VANDERBILT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2016-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8645740
关键词：
Accounting Affect Amygdaloid structure Arousal Autistic Disorder Behavior Behavior Therapy Behavioral Biological Biological Markers Brain Brain region Child Child Behavior Code Cognitive deficits Computers Data Defect Disease Emotional Emotional Disturbance Equipment Exhibits Exposure to Frequencies Functional Magnetic Resonance Imaging Goals Heterogeneity Home environment Hormones Human Hydrocortisone Hypothalamic structure Imaging Techniques Individual Investigation Language Disorders Measurement Measures Methods Modeling Neurobiology Neurosecretory Systems Participant Pattern Performance Periodicity Physiological Pituitary Gland Play Process Regulation Rewards Salivary Sampling Social Behavior Social Interaction Social Problems Stress Symptoms Techniques Toy Variant base behavior observation falls frontal lobe indexing neuroimaging novel peer preference psychobiologic psychobiology public health relevance relating to nervous system response social

项目摘要

DESCRIPTION (provided by applicant): Autism is currently widely viewed as a spectrum disorder with affected individuals having varying degrees of social and emotional disturbances. In the present application we describe a new conceptualization of autism in order to account for some of the heterogeneity. In the application, a neuroendocrine spectrum model is proposed in which aspects of emotional reactivity, social responsiveness and biological indices intersect to define distinct subtypes. The investigation involves three interrelated studies of socioemotional functioning utilizing several methods of analysis to include the assessment of biological markers of emotional arousal and stress, sophisticated behavioral observational techniques, and functional neuroimaging in order to carefully explore the psychobiological profiles of children with and without autism. Specifically, during peer interactions of a playground activity, sophisticated behavioral observation will be obtained to evaluate the frequency, duration and interactive sequences exhibited by children with autism. These data will be analyzed with stress hormones to uncover relationships between behavioral and biological symptom profiles. In addition, we will explore brain activation patterns in these children while they play games with different computer and human partners. It is anticipated that this comprehensive study of "real world" social interactions will allow us to uncover meaningful associations between the child's behavior, biological profiles and brain activity before, during and after play with peers. The ultimate goal is that these results will better inform our understanding of autism to allow us to provide individualized biological and behavioral treatments.

描述（由申请人提供）：自闭症当前被广泛视为一种频谱障碍，受影响的人具有不同程度的社会和情感障碍。在本应用程序中，我们描述了自闭症的新概念，以说明某些异质性。在应用程序中，提出了神经内分泌光谱模型，其中情感反应性，社会反应能力和生物学指数的各个方面相交以定义不同的亚型。该研究涉及使用几种分析方法的三个相互关联的社会情感功能研究，包括评估情绪唤醒和压力的生物学标志物，复杂的行为观察技术以及功能性神经影像学，以仔细探索儿童的精神生物学特征。具体而言，在操场活动的同伴相互作用期间，将获得复杂的行为观察，以评估自闭症儿童表现出的频率，持续时间和互动序列。这些数据将用应力激素分析，以发现行为和生物症状概况之间的关系。此外，我们将在与不同的计算机和人类合作伙伴玩游戏时探索这些孩子的大脑激活模式。可以预料，这项对“现实世界”社会互动的全面研究将使我们能够在与同龄人一起玩之前，之中和之后发现孩子的行为，生物学特征和大脑活动之间的有意义的关联。最终目标是，这些结果将更好地告知我们对自闭症的理解，使我们能够提供个性化的生物学和行为治疗。