Frontiers in Alzheimer's and Aging Research (FrA2R)

项目摘要 此请求是对PAR-17-290的回应，旨在为我们的R25奖项更新NIA赞助， “阿尔茨海默氏症和衰老研究前沿（FrA 2 R：R25 AG 043365 -05）”，在NIA的“推进 通过本科教育老龄化研究的多样性”计划。专为具有竞争力的高级 本科生，特别是代表性不足的少数民族（URM），FrA 2 R提供创新， 阿尔茨海默病和相关痴呆症（ADRD）和衰老的复杂研究教育 机制等以确保下一代老年痴呆症和衰老研究人员得到高级培训 机会，我们提供FrA 2 R课程在医学院莫尔豪斯（2019年，2021年，2023年）和泽维尔 路易斯安那大学（2020和2022）。为此，我们将继续加强和扩大研究 最有前途的科学家的职业生涯，与敏感性，以确保在NIA劳动力的充分多样性。 重要的是，ADRD和老化领域继续快速增长，但由URM领导的实验室太少 科学家和太少的新URM学员。FrA 2 R由Gerald Schatten博士领导， Pittsburgh，沿着与S. Michal Jazwinski博士，来自杜兰大学，Laura Niedernhofer博士，来自斯克里普斯大学， 作为Co-Is，与来自Xavier的培训/指导协调员Harris McFerrin博士一起，卡尔文Simerly， 博士，从皮特，和温斯顿汤普森，博士，从莫尔豪斯;他们共同组成的执行 以马克思它由一个由ADRD和衰老研究名人组成的科学咨询委员会监督。 FrA 2 R提供动态的高级培训课程，包括日常讲座和扩展讨论， 新兴概念，然后是实验室研究和技术密集型讲习班， 为期一周的研讨会（2019年5月12日至18日在Morehouse首次续订）。这种先进 指导提供“动手”培训，为16个高度竞争的参与者（申请人查询， 接受的候选人是>4.3：1）对阿尔茨海默氏症的根本原因和机制的老化。课程结束后， 与每个受训者保持频繁的互动。在80名受训者中，39%的人认为自己是非洲裔美国人。 19%为西班牙裔美国人; 70%为女性，44%来自URM机构。早期结果显示， 他们在老年痴呆症和老龄化研究事业中取得了进展，如医学博士、医学博士兼博士或博士。五个目标 是：I.提供概念教育和实验室培训的先进方法和新兴的 关于阿尔茨海默氏症和衰老机制的发现，特别是与我们的非洲裔美国人有关的发现， 社区.二.通过负责任的行为培训， 研究、伦理、法律的和社会影响，特别是多样性和健康问题 差距。三.支持指导试点研究项目;四。鼓励学员和校友的长期 职业规划; V.评估，改进和监控FrA 2 R的优势，避免弱点， 定量独立机制。

PROJECT SUMMARY This request, responsive to PAR-17-290, seeks to renew NIA sponsorship for our R25 award entitled “Frontiers in Alzheimer’s and Aging Research (FrA2R: R25 AG043365-05),” within NIA’s “Advancing Diversity in Aging Research through Undergraduate Education” program. Designed for competitive advanced undergraduate students, especially under-represented minorities (URMs), FrA2R provides innovative, sophisticated research education in Alzheimer’s disease and related dementias (ADRD) and aging mechanisms. To ensure that the next generation of Alzheimer’s and aging researchers have advanced training opportunities, we offer the FrA2R course at Morehouse School of Medicine (2019, 2021, 2023) and Xavier University of Louisiana (2020 and 2022). In so doing, we will continue to enhance and expand the research careers of the most promising scientists, with sensitivity to ensuring full diversity in the NIA workforce. Importantly, the ADRD and aging fields continue to grow swiftly, yet there are too few laboratories led by URM scientists and too few new URM trainees. FrA2R is under the directorship of Gerald Schatten, PhD, from Pittsburgh, along with S. Michal Jazwinski, PhD, from Tulane and Laura Niedernhofer, MD, PhD, from Scripps, as Co-Is, together with Training/Mentoring Coordinators Harris McFerrin, PhD, from Xavier, Calvin Simerly, PhD, from Pitt, and Winston Thompson, PhD, from Morehouse; together they comprise the Executive Committee. It is overseen by a scientific advisory board composed of ADRD and aging-research luminaries. FrA2R offers dynamic advanced training courses consisting of daily lectures and extended discussion on emerging concepts, followed by laboratory research and technologically intense workshops and informal seminars over week-long periods (first renewal offering May 12-18, 2019 at Morehouse). This advanced instruction provides “hands-on” training for 16 highly competitive participants (the ratio of applicant inquiries to accepted candidates is >4.3:1) on Alzheimer’s root causes and mechanisms of aging. After the course, frequent interactions are maintained with each trainee. Of the 80 trainees, 39% identify as African-American and 19% as Hispanic-American; 70% are women, and 44% are from URM institutions. Early results show that they are progressing in Alzheimer’s and aging-research careers, as MDs, MD-PhDs, or PhDs. The five aims are to: I. Provide conceptual education and laboratory training in the sophisticated methods and emerging discoveries on Alzheimer’s and aging mechanisms, especially as relevant for our African-American communities. II. Demystify the regulatory oversight requirements by training in responsible conduct of research, the ethical, legal and societal implications, and especially problems of diversity and health disparities. III. Support mentored pilot research projects; IV. Encourage trainees’ and alumni’s longer-term career planning; V. Evaluate, improve and monitor FrA2R’s strengths and avoid weaknesses with unbiased, quantitative independent mechanisms.