Frontiers in Alzheimer's and Aging Research (FrA2R)

阿尔茨海默病和衰老研究前沿 (FrA2R)

• 批准号: 10441312
• 负责人: GERALD SCHATTEN
• 金额: $ 37.1万
• 依托单位: MAGEE-WOMEN'S RES INST AND FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-30 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10441312
• 关键词: Achievement; African American; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Attention; Biological; Communities; Congresses; Dementia; Doctor of Philosophy; Educational workshop; Ensure; Ethics; Funding; Hispanic Americans; Institution; Instruction; Investments; Laboratories; Laboratory Research; Legal; Louisiana; Mentors; Methods; Minority-Serving Institution; Molecular Genetics; Monitor; Morehouse School of Medicine; Nature; Outcome; Participant; Plant Roots; Population Scientist Supplement (R25); Quality of life; Reagent; Research; Research Personnel; Research Project Grants; Scientist; Series; Students; Training; Training and Education; Underrepresented Minority; Universities; Vocational Guidance; Woman; biomedical profession; career; cost effective; design; education research; experience; frontier; genetic approach; health disparity; improved; innovation; laboratory experience; lectures; minority scientist; minority trainee; next generation; peer; people of color; programs; response; responsible research conduct; training opportunity; undergraduate education; undergraduate student

PROJECT SUMMARY This request, responsive to PAR-17-290, seeks to renew NIA sponsorship for our R25 award entitled “Frontiers in Alzheimer’s and Aging Research (FrA2R: R25 AG043365-05),” within NIA’s “Advancing Diversity in Aging Research through Undergraduate Education” program. Designed for competitive advanced undergraduate students, especially under-represented minorities (URMs), FrA2R provides innovative, sophisticated research education in Alzheimer’s disease and related dementias (ADRD) and aging mechanisms. To ensure that the next generation of Alzheimer’s and aging researchers have advanced training opportunities, we offer the FrA2R course at Morehouse School of Medicine (2019, 2021, 2023) and Xavier University of Louisiana (2020 and 2022). In so doing, we will continue to enhance and expand the research careers of the most promising scientists, with sensitivity to ensuring full diversity in the NIA workforce. Importantly, the ADRD and aging fields continue to grow swiftly, yet there are too few laboratories led by URM scientists and too few new URM trainees. FrA2R is under the directorship of Gerald Schatten, PhD, from Pittsburgh, along with S. Michal Jazwinski, PhD, from Tulane and Laura Niedernhofer, MD, PhD, from Scripps, as Co-Is, together with Training/Mentoring Coordinators Harris McFerrin, PhD, from Xavier, Calvin Simerly, PhD, from Pitt, and Winston Thompson, PhD, from Morehouse; together they comprise the Executive Committee. It is overseen by a scientific advisory board composed of ADRD and aging-research luminaries. FrA2R offers dynamic advanced training courses consisting of daily lectures and extended discussion on emerging concepts, followed by laboratory research and technologically intense workshops and informal seminars over week-long periods (first renewal offering May 12-18, 2019 at Morehouse). This advanced instruction provides “hands-on” training for 16 highly competitive participants (the ratio of applicant inquiries to accepted candidates is >4.3:1) on Alzheimer’s root causes and mechanisms of aging. After the course, frequent interactions are maintained with each trainee. Of the 80 trainees, 39% identify as African-American and 19% as Hispanic-American; 70% are women, and 44% are from URM institutions. Early results show that they are progressing in Alzheimer’s and aging-research careers, as MDs, MD-PhDs, or PhDs. The five aims are to: I. Provide conceptual education and laboratory training in the sophisticated methods and emerging discoveries on Alzheimer’s and aging mechanisms, especially as relevant for our African-American communities. II. Demystify the regulatory oversight requirements by training in responsible conduct of research, the ethical, legal and societal implications, and especially problems of diversity and health disparities. III. Support mentored pilot research projects; IV. Encourage trainees’ and alumni’s longer-term career planning; V. Evaluate, improve and monitor FrA2R’s strengths and avoid weaknesses with unbiased, quantitative independent mechanisms.

项目总结 此请求响应PAR-17-290，旨在续签NIA对我们的R25奖的赞助，该奖项名为 《阿尔茨海默氏症和衰老研究的前沿》(FrA2R：R25 AG043365-05)，《在NIA的前进中》 通过本科教育实现老龄化研究的多样性“计划。专为具有竞争力的高级产品而设计 本科生，特别是代表不足的少数族裔(URM)，FrA2R提供创新的、 阿尔茨海默病和相关痴呆症(ADRD)和老龄化方面的复杂研究教育 机制。为了确保下一代阿尔茨海默氏症和老龄化研究人员接受高级培训 机会，我们在莫尔豪斯医学院(2019、2021、2023)和泽维尔开设FrA2R课程 路易斯安那大学(2020年和2022年)。在这样做的同时，我们将继续加强和扩大研究 最有前途的科学家的职业生涯，并敏锐地确保NIA工作人员的充分多样性。 重要的是，ADRD和老龄化领域继续快速增长，但由URM领导的实验室太少 科学家和太少的新URM实习生。FrA2R由Gerald Schatten博士担任董事，来自 与来自杜兰的S.Michal Jazwinski博士和来自斯克里普斯的Laura Niedernhofer博士一起， 作为联合-IS，与来自泽维尔的培训/指导协调员哈里斯·麦克费林博士，卡尔文·西姆利， 皮特大学的博士和莫尔豪斯学院的温斯顿·汤普森博士；他们一起组成了高管 委员会审议阶段。它由一个由ADRD和老龄化研究知名人士组成的科学顾问委员会监督。 FrA2R提供充满活力的高级培训课程，包括每天的讲座和关于 新兴概念，随后是实验室研究和技术密集讲习班和非正式 为期一周的研讨会(2019年5月12日至18日在莫尔豪斯举行首次续订活动)。这是一种高级 指导课程为16名竞争激烈的学员提供“动手”培训(申请者咨询与 被接受的候选人是&gt；4.3：1)关于阿尔茨海默氏症的根本原因和衰老机制。课程结束后， 与每个受训人员保持频繁的互动。在80名受训人员中，39%的人认为自己是非洲裔美国人 19%的人是西班牙裔美国人；70%的人是女性，44%的人来自URM机构。初步结果显示， 他们在阿尔茨海默氏症和衰老研究生涯中取得了进步，成为医学博士、医学博士或博士。五个目标 是：一、提供概念教育和实验室培训的先进方法和新兴技术 关于阿尔茨海默氏症和衰老机制的发现，特别是与我们的非裔美国人相关的发现 社区。通过培训负责任的行为来揭开监管监督要求的神秘面纱 研究、伦理、法律和社会影响，特别是多样性和健康问题 差距。支持有指导的先导研究项目；IV.鼓励学员和校友的长期 五、评估、改进和监控FrA2R的优势，避免劣势， 数量上的独立机制。