Forefronts in Substance Abuse Disorders during Pregnancy, Postpartum, and Pediatrics (FrSADP3)

妊娠期、产后和儿科药物滥用疾病的前沿 (FrSADP3)

• 批准号: 10741269
• 负责人: GERALD SCHATTEN
• 金额: $ 38.29万
• 依托单位: MAGEE-WOMEN'S RES INST AND FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10741269
• 关键词: Address; Advocate; Animals; Birth; Career Choice; Career Mobility; Child; Clinical; Clinical Research; Collaborations; Color; Communities; Dental; Development Plans; Discipline of Nursing; Disease; Doctor of Pharmacy; Doctor of Philosophy; Education; Educational process of instructing; Ensure; Environment; Evaluation; Faculty; Fostering; Future; Goals; Health Insurance Portability and Accountability Act; Hispanic-serving Institution; IACUC; Indigenous American; Individual; Inequity; Institutional Review Boards; Investments; Laws; Leadership; Medical; Mentors; Methods; Minority-Serving Institution; National Institute of Drug Abuse; Participant; Pediatrics; Persons; Pharmaceutical Preparations; Postdoctoral Fellow; Postpartum Period; Pregnancy; Psychologist; Qualifying; Reproducibility; Research; Research Personnel; Research Training; Resources; Risk; Safety; Scientist; Self Administration; Students; Substance abuse problem; Supreme Court Decisions; Therapeutic; Toddler; Training; Underrepresented Minority; United States National Institutes of Health; Universities; Vulnerable Populations; Women' s Health; addiction; career; design; drug withdrawal; education research; ethical, legal, and social implication; experience; healthy lifestyle; innovation; insight; lectures; member; minority trainee; neonate; peer; pregnant; programs; responsible research conduct; skill acquisition; substance use; translational approach

PROGRAM SUMMARY This proposal “Forefronts in Substance Abuse Disorders during Pregnancy, Postpartum and Pediatrics (FrSADP3)” requests its first renewal within NIDA’s Research Education Program. The primary rationale is that there are too few underrepresented minority (URM) clinicians and clinical researchers, too few clinical and research programs investigating substance use (SU) and abuse (SA), and especially, substance abuse disorders (SAD) during pregnancy, postpartum, and in pediatrics (P3); there are far too few new URM trainees for clinical and clinical research careers within the SADP3 fields. Many innovations include optimizing the depth, breadth, and scope of SAD topics of concern during and following pregnancy and the leadership and participation of Indigenous Americans. Our objectives are to train, mentor, provide meaningful research experiences for and help launch the clinical careers of SAD Clinicians and Clinical Scientists (R25 Clinical Trainees). FrSADP3 includes PI and Program Director Gerald Schatten, PhD, at Pitt and Co- I Aimee McRae- Clark, PharmD, BCPP (Addiction Research Leader), with Theresa Cronan, PhD, at SDSU (Facilitator, Psychologist, URM and Women’s Health), Calvin Simerly, PhD, at Pitt (Program Coordinator), and Evan Snyder, MD, PhD, at SBP (Addiction Neonatologist). It is overseen by a Scientific Advisory Board, 40% who are URM faculty. Five Specific Aims: I. Annual FrSADP3 advanced hands-on lab courses, offered at a URM Institution at which we provide conceptual education, expert guided discussions and research training in the methods necessary for studying pregnant people with or at risk for SAD and their neonates, toddlers, and children; relevant animals that self-administer drugs; and the mechanisms of and therapeutic strategies to alleviate the suffering from SADP3, along with research resources available at NIDA and elsewhere. II. Mentored Research into substance use and abuse disorders during pregnancy, postpartum and pediatrics, launched by the participant, together with any FrSADP3 faculty member. III. Encourage trainees’ longer-term Career Planning and gently exploring their self-identified career choices, particularly within the possibilities of them joining NIDA-NIH’s clinical and research workforce. IV. Demystify the changing regulatory oversight requirements in Responsible Conduct for Research (RCR) to ensure full compliance with the NIH’s guidance. V. Unbiased, Quantitative Independent Evaluations to track participants’ careers. The R25’s goals, then, are to provide courses in skills development, mentored addiction research, and ongoing career support resulting in comprehensive, sophisticated training in clinical and translational strategies for addressing the current challenges in addiction during pregnancy, for designing better therapies for the future, and for launching and sustaining successful careers in substance abuse, pregnancy, pediatrics, and related fields. In so doing, FrSADP3 will continue to advance the careers of the most promising clinical scientists and clinicians, with sensitivity for ensuring full diversity in the NIDA workforce.

程序摘要 该提议“怀孕，产后和儿科期间的药物滥用障碍的最前沿 （FRSADP3）”要求在NIDA的研究教育计划中首次续签。主要理由是 代表性不足的少数民族（URM）临床医生和临床研究人员太少，临床和 研究药物使用（SU）和滥用（SA）的研究计划，尤其是滥用药物 怀孕，产后和儿科期间的疾病（悲伤）（P3）；新的URM培训太少了 用于SADP3领域内的临床和临床研究职业。许多创新包括优化 怀孕和领导力期间和之后的令人关注的令人难过的主题的深度，广度和范围 土著美国人的参与。我们的目标是培训，精神，提供有意义的研究 经验并帮助启动SAD临床医生和临床科学家的临床职业（R25临床 学员）。 FRSADP3包括PI和PHERD PITT博士的PIS和计划总监，位于Pitt和Co- I Aimee McRae- Clark，PharmD，BCPP（成瘾研究负责人），SDSU的Theresa Cronan博士（主持人， 心理学家，URM和妇女健康），Pitt（计划协调员）和埃文（Evan）的Calvin Simerly，博士学位 SBP的Snyder，医学博士（成瘾新生儿学家）。它由科学顾问委员会监督，40％ 是URM教师。五个具体目标：I。年度FRSADP3高级实验实验室课程，在 我们提供概念教育，专家指导讨论和研究的URM机构 研究有或有危险及其新生儿风险的孕妇所必需的方法的培训， 幼儿和孩子；自我管理药物的相关动物；以及和 减轻SADP3苦难的治疗策略，以及可用的研究资源 NIDA和其他地方。 ii。指导了怀孕期间对药物使用和滥用障碍的研究 由参与者与任何FRSADP3教职员工一起发起的产后和儿科。 iii。 鼓励学员的长期职业计划，并轻轻探索他们自我认同的职业选择， 特别是在他们加入NIDA-NIH的临床和研究人员的可能性中。 iv。神秘面纱 负责研究行为（RCR）的监管监督要求不断变化，以确保充分 遵守NIH的指导。 V.无偏的定量独立评估以跟踪 参与者的职业。因此，R25的目标是提供技能开发的课程，减少成瘾 研究以及持续的职业支持，从而在临床和 针对怀孕期间成瘾中当前挑战的翻译策略，设计 对未来的更好疗法，以及从事滥用药物的成功职业， 怀孕，儿科和相关领域。这样做，FRSADP3将继续发展 最有前途的临床科学家和临床医生，对确保NIDA劳动力的全部多样性具有敏感性。

项目成果

Modeling Complex Neurological Diseases with Stem Cells: A Study of Bipolar Disorder.

• DOI: 10.1007/978-3-319-93485-3_12
• 发表时间: 2018
• 期刊: Results and problems in cell differentiation
• 作者: C. Pernia;Neal H. Nathan;B. Tobe;A. Winquist;R. Sidman;Y. Goshima;E. Snyder