Task Order One (1) shall encompass conduct of and support for student training and education activities, support for educational and training activities, and preparation of manuscripts.

任务令一 (1) 应包括开展和支持学生培训和教育活动、支持教育和培训活动以及准备稿件。

• 批准号: 10469962
• 负责人: MARINELLE PAYTON
• 金额: $ 107.75万
• 依托单位: JACKSON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-13 至 2022-08-12
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10469962
• 关键词: Abdomen; African American; Aorta; Area; Atherosclerosis Risk in Communities; Back; Behavioral Genetics; Biochemical; Biological; Biological Assay; Biomedical Research; Candidate Disease Gene; Cardiac; Cardiovascular Diseases; Cardiovascular system; Communities; Community Health Education; County; Cryopreservation; DNA; Data; Data Collection; Data Set; Disease; Echocardiography; Education and Outreach; Educational Activities; Educational Status; Enrollment; Environmental Risk Factor; Future; Genetic Risk; Genome Scan; Investigation; Jackson Heart Study; Knowledge; Lymphocyte; Magnetic Resonance Imaging; Manuscripts; Mathematics; Measures; Mentorship; Participant; Population; Preparation; Psychosocial Factor; Publications; Research; Resources; Risk Factors; Sampling; Science; Scientist; Students; Training; Training Activity; Training Programs; Training and Education; Underrepresented Minority; X-Ray Computed Tomography; aged; base; biomedical profession; cardiovascular disorder epidemiology; cardiovascular disorder risk; cardiovascular health; career; cohort; college; community living; disorder risk; epidemiology study; graduate student; healthy lifestyle; heart imaging; high school; innovation; interest; metropolitan; minority undergraduate; novel; programs; recruit; social culture; socioeconomics; student training; undergraduate student; underrepresented minority student

The Jackson Heart Study (JHS), initiated in 1998, is a longitudinal investigation of genetic and environmental risk factors associated with the disproportionate burden of cardiovascular disease (CVD) in African-Americans. In addition, the JHS performs a variety of community education and outreach activities to promote healthy lifestyles and reduce disease risk burden. It also conducts college undergraduate and graduate-level training programs and high school science and math enrichment programs to prepare and encourage underrepresented minority students to pursue biomedical careers. (www.jacksonheartstudy.org/ ). The JHS represents an expansion of the Jackson Field Center of the Atherosclerosis Risk in Communities (ARIC) study (www2.cscc.unc.edu/aric/), to broaden data collection in an African- American population and to increase access to and participation of African American populations and scientists in biomedical research and professions. The study recruited 5306 African-American residents, including 3,732 residents also enrolled in ARIC, living in the Jackson, MS, metropolitan area of Hinds, Madison, and Rankin Counties. Enrolled JHS participants, initially aged 20 - 90 years, received three back-to-back examinations (Exam 1, 2000-04; Exam 2, 2005-08; and Exam 3, 2009-13) and have been contacted annually. Findings on the rich set of data on physical, behavioral, genetic, and psychosocial factors have been presented in over 345 publications as of the end of 2016. The wealth of data and biological samples collected since the study’s inception as well as the potential for new data collection from JHS participants offer vast opportunities for new scientific discoveries. Participant exams have produced extensive longitudinal data on traditional and putative CVD risk factors, socioeconomic and sociocultural factors, and biochemical analytes; and measures of subclinical disease from echocardiography, cardiac magnetic resonance imaging (MRI), and computed tomography (CT) scans of the heart, aorta, and abdomen. Stored biological samples have been assayed for putative biochemical risk factors and stored for future research. DNA has been extracted and lymphocytes cryopreserved for study of candidate genes, genome-wide scanning, expression, and other –omics investigations.

杰克逊心脏研究（JHS）于1998年启动，是一项对与非洲裔美国人心血管疾病（CVD）负担不成比例相关的遗传和环境风险因素的纵向调查。 此外，JHS执行各种社区教育和外展活动，以促进健康的生活方式和减少疾病风险负担。 它还开展大学本科和研究生水平的培训计划以及高中科学和数学充实计划，以准备和鼓励代表性不足的少数民族学生从事生物医学职业。（www.jacksonheartstudy.org/）中找到。 JHS是社区动脉粥样硬化风险研究（ARIC）杰克逊现场中心的扩展（www2.cscc.unc.edu/aric/），以扩大非裔美国人的数据收集，并增加非裔美国人和科学家在生物医学研究和专业中的接触和参与。 这项研究招募了5306名非洲裔美国居民，其中包括3,732名也参加了ARIC的居民，他们居住在杰克逊、MS、Hinds、麦迪逊和兰金县的大都市区。 登记的JHS参与者，最初年龄在20 - 90岁之间，接受了三次背靠背的考试（考试1，2000-04;考试2，2005-08;和考试3，2009-13），并每年联系一次。截至2016年底，关于身体、行为、遗传和心理社会因素的丰富数据集的研究结果已发表在超过345篇出版物中。 自研究开始以来收集的大量数据和生物样本，以及从JHS参与者那里收集新数据的潜力，为新的科学发现提供了巨大的机会。参与者检查产生了关于传统和推定的CVD风险因素、社会经济和社会文化因素以及生化分析物的广泛纵向数据;以及超声心动图、心脏磁共振成像（MRI）和心脏、主动脉和腹部计算机断层扫描（CT）的亚临床疾病测量。储存的生物样品已被测定推定的生化风险因素，并储存用于未来的研究。提取DNA并冷冻保存淋巴细胞用于候选基因的研究、全基因组扫描、表达和其他组学研究。