NMR User Program at NMRFAM

项目总结 位于麦迪逊的国家磁共振设施(NMRFAM)提供了及时和可靠的访问成熟的 核磁共振技术应用于广泛的生物医学研究问题。NMRFAM有工作人员 几十年的设施运营和维护经验，配备了十几台高场核磁共振波谱仪 拥有最先进的探测技术和设施基础设施(充足的空间、不间断的电源系统、 环境控制、氦回收)首屈一指，NMRFAM一直走在 标准化，通过公平(可查找、可访问、可互操作和可重复使用)数据进行数据管理 原则和向社区传播最佳做法。通过NIGMS R24计划提供支持 NMRFAM通过NIGMS的R24机制将支持广泛访问这一特殊资源 麦迪逊将利用规模经济，包括稳定高效的运营，最大限度地提高数据质量和 最大限度地减少仪器停机时间，为科学家无法进行的多种类型的实验提供便利 他们的本土机构。此外，拟议的下一代用户计划提高了严格性和 通过仪器质量控制收集核磁共振数据的重复性、标准操作程序、新的 微晶蛋白质和核酸、膜蛋白质和纤维的样品标准，包括 发展动力、功能和结构的方法。NMRFAM工作人员提供 根据个人用户和项目的需求量身定做的卓越服务级别，可以说是服务范围最广的服务 美国任何核磁共振设施的用户群。NMRFAM积极寻求通过外联来支持不同的用户 和用户培训机会(研讨会、视频教程、协议)，以教用户如何理解和 分析他们的核磁共振数据。NMRFAM的目标是为用户提供更多的频谱，该设施提供 工作人员支持和自动化工具，以返回交付成果：即，科学知识，而不仅仅是数据。NMRFAM 任务降低了核磁共振的门槛，并在用户可以成功应用 核磁共振数据来回答他们感兴趣的生物学问题。NMRFAM已经建立了顶级设施的声誉 对于外部用户，该项目将保持对NMRFAM的负担得起的访问。NMRFAM的工作人员将定期 评估业绩标准，并与外部咨询委员会和设施用户协商，以便 该设施继续保持领先地位，满足其用户群的需求。

PROJECT SUMMARY The National Magnetic Resonance Facility at Madison (NMRFAM) provides timely and reliable access to mature NMR technology for application to a wide array of biomedical research questions. NMRFAM has staff with decades of experience in facility operation and maintenance, a dozen high-field NMR spectrometers equipped with state-of-the-art probe technology, and facility infrastructure (ample space, uninterrupted power systems, environmental control, helium recovery) second to none, and NMRFAM has been at the forefront of standardization, data stewardship through FAIR (findable, accessible, interoperable and reusable) data principles and dissemination of best practices to the community. Support through the NIGMS R24 program of NMRFAM through the R24 mechanism at NIGMS would support broad access to this exceptional resource in Madison to leverage economies of scale, including stable and efficient operation that maximizes data quality and minimizes instrument down time, facilitating many types of experiments that scientists are not able to perform at their home institutions. Furthermore, the proposed next generation user program improves the rigor and reproducibility of NMR data collection through instrument quality control, standard operating procedures, new sample standards for microcrystalline proteins and nucleic acids, membrane proteins and fibrils, including development of approaches for dynamics and function as well as structure. NMRFAM staff provide an exceptional level of service tailored to the needs of individual users and projects, serving arguably the broadest user base of any NMR facility in the US. NMRFAM actively seeks to support diverse users through outreach and user training opportunities (workshops, video tutorials, protocols) to teach users how to understand and analyze their NMR data. NMRFAM has a goal of providing users more than spectra, and the facility provides staff support and automation tools to return deliverables: i.e., scientific knowledge not only data. The NMRFAM mission lowers barriers to NMR and maximizes the impact of the facility when users can successfully apply the NMR data to answer their biological question of interest. NMRFAM has built a reputation as a top-level facility for external users and this project will maintain affordable access to NMRFAM. NMRFAM staff will regularly evaluate performance criteria and consult with the external advisory committee and facility users so that the facility continues to remain at the cutting edge and meet the needs of its user base.