Kansas PKD Research and Translation Core Center
堪萨斯 PKD 研究与翻译核心中心
基本信息
- 批准号:10475035
- 负责人:
- 金额:$ 75.72万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-15 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:Autosomal Dominant Polycystic KidneyBasic ScienceBiochemistryBiocompatible MaterialsBiological MarkersBiomedical ResearchCancer CenterCell modelCell physiologyCellular biologyClinicalClinical ResearchClinical TrialsClinical Trials NetworkCollaborationsCommunitiesCystDevelopmentDiseaseDrug TargetingEducational workshopEffectivenessEnvironmentFoundationsGoalsGrantGrowthInfrastructureInstitutesInstitutionInterdisciplinary StudyKansasKidneyMedical centerMethodsMissionPathogenesisPatient-Focused OutcomesPatientsPolycystic Kidney DiseasesReagentRecording of previous eventsResearchResearch MethodologyResearch PersonnelResearch SupportResource SharingResourcesRodent ModelSeriesServicesSiteTechnologyTestingTranslationsUniversitiesbasebiomarker discoveryclinical developmentdrug testingeducational atmosphereimprovedinnovationinsightinter-institutionalmeetingsmultidisciplinarynew technologynovel therapeutic interventionnovel therapeuticspatient orientedprogramsrecruitsummer studentsymposiumtherapeutic targettooltranslational medicine
项目摘要
Project Summary – Overall
The Kansas PKD Research and Translation Core Center (RTCC) is comprised of an Administrative Core and
three innovative Biomedical Research Cores: Core 1: Biomarkers, Biomaterials, and Cellular Models; Core 2:
Rodent Models & Drug Testing; and Core 3: Clinical Research. The Kansas RTCC also offers an Educational
Enrichment Program and an internal Pilot Grant Program in partnership with the KU Cancer Center. The
mission of the PKD Center is to promote PKD research by providing both innovative and essential reagents,
biomaterials, and service to the national PKD research community for the advancement of our understanding
of disease mechanisms, the discovery of biomarkers and therapeutic targets and the development of clinical
trials to improve patient outcomes. The Specific Aims of the Kansas PKD RTCC are: Aim 1) To support PKD
researchers nationally by developing innovative biomedical research cores. This will be accomplished by
developing the expertise, reagents and resources required to bring the best new technologies to PKD research
to meet the needs of the greater PKD research community; by leveraging existing institutional shared
resources to expand our capability, efficiency, and effectiveness; and by developing tools to support clinical
research and establish collaborations both regionally and nationally to develop a multi-institutional ADPKD
clinical trials network. Aim 2) To develop a skilled, collaborative, multidisciplinary basic science and clinical
PKD research investigator base. This will be accomplished by building on our broad multidisciplinary research
base and continuing to recruit new investigators from outside the PKD field by offering an innovative pilot grant
program that will attract new investigators to the field, and by providing new investigators, nationally, with
research support for core services, new technologies, educational opportunities, and an open and collaborative
research environment that will help them succeed. Aim 3) To enhance the PKD research environment with
educational programs to support ongoing projects and to develop new research directions. The research
environment will be enhanced through a seminar program, Summer Student Enrichment Program, PKD lab
meetings, PKD methods workshops, Research Methods and Advanced Technologies Program, professional
development seminar series, patient-oriented activities, and by participating in the consortium-wide annual
symposium. Aim 4) To develop partnerships regionally and nationally and to build teams to serve as a
resource for the greater PKD research community. Inter-institutional partnerships will provide local and national
infrastructure support, new research technologies, increased numbers of patients involved in clinical trials, and
research collaborators for the development of new research opportunities by attracting investigators from other
fields into PKD research from collaborating sites within the PKD Research Consortium and with cooperating
institutions nationwide, broadening opportunities beyond what any single institution can provide.
项目摘要--总体
堪萨斯州PKD研究和翻译核心中心(RTCC)由一个管理核心和
三个创新的生物医学研究核心:核心1:生物标志物、生物材料和细胞模型;核心2:
啮齿动物模型和药物测试;核心3:临床研究。堪萨斯州RTCC还提供了一项教育
与昆士兰州立大学癌症中心合作的增富计划和内部试点资助计划。这个
PKD中心的使命是通过提供创新和必要的试剂来促进PKD研究,
生物材料,并为国家PKD研究界提供服务,以促进我们的理解
疾病机制、生物标志物和治疗靶点的发现以及临床的发展
改善患者预后的试验。堪萨斯州PKD RTCC的具体目标是:目标1)支持PKD
通过开发创新的生物医学研究核心,在全国范围内开展研究。这将通过以下方式实现
开发为PKD研究带来最佳新技术所需的专业知识、试剂和资源
满足更大的PKD研究社区的需求;通过利用现有的机构共享
资源,以扩大我们的能力、效率和效力;并通过开发工具来支持临床
研究和建立区域和国家之间的合作,以发展多机构的联合国开发计划署
临床试验网络。目标2)发展熟练、协作、多学科的基础科学和临床
PKD研究调查员基地。这将通过我们广泛的多学科研究来实现
基地,并通过提供创新的试点赠款,继续从PKD领域以外征聘新的调查员
该计划将吸引新的调查人员进入该领域,并通过在全国范围内为新的调查人员提供
为核心服务、新技术、教育机会和开放协作的研究提供支持
将帮助他们取得成功的研究环境。目的3)通过以下方式加强PKD研究环境
支持正在进行的项目和开发新的研究方向的教育计划。这项研究
将通过PKD实验室的暑期学生充实计划研讨会计划来改善环境
会议、PKD方法研讨会、研究方法和高级技术计划、专业人员
发展研讨会系列,以患者为中心的活动,并通过参加全财团的年度
研讨会。目标4)在区域和国家发展伙伴关系,并建立团队,作为
为更大的PKD研究社区提供的资源。机构间伙伴关系将为地方和国家提供
基础设施支持、新的研究技术、参与临床试验的患者数量增加,以及
研究合作者通过吸引来自其他国家的研究人员来开发新的研究机会
从PKD研究联盟内的合作站点和与合作机构合作进入PKD研究领域
全国范围内的机构,拓宽了任何一家机构所能提供的机会。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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DARREN P. WALLACE其他文献
DARREN P. WALLACE的其他文献
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{{ truncateString('DARREN P. WALLACE', 18)}}的其他基金
Biomedical Research Core 1 - Biomarkers, Biomaterials, and Cellular Models Core
生物医学研究核心 1 - 生物标志物、生物材料和细胞模型核心
- 批准号:
10475041 - 财政年份:2020
- 资助金额:
$ 75.72万 - 项目类别:
Biomedical Research Core 1 - Biomarkers, Biomaterials, and Cellular Models Core
生物医学研究核心 1 - 生物标志物、生物材料和细胞模型核心
- 批准号:
10214614 - 财政年份:2020
- 资助金额:
$ 75.72万 - 项目类别:
Additional Informatics support on U54 Clinical Core
U54 临床核心的附加信息学支持
- 批准号:
10890529 - 财政年份:2020
- 资助金额:
$ 75.72万 - 项目类别:
Biomedical Research Core 1 - Biomarkers, Biomaterials, and Cellular Models Core
生物医学研究核心 1 - 生物标志物、生物材料和细胞模型核心
- 批准号:
10059766 - 财政年份:2020
- 资助金额:
$ 75.72万 - 项目类别:
Kansas PKD Research and Translation Core Center
堪萨斯 PKD 研究与翻译核心中心
- 批准号:
10686046 - 财政年份:2020
- 资助金额:
$ 75.72万 - 项目类别:
Biomedical Research Core 1 - Biomarkers, Biomaterials, and Cellular Models Core
生物医学研究核心 1 - 生物标志物、生物材料和细胞模型核心
- 批准号:
10686060 - 财政年份:2020
- 资助金额:
$ 75.72万 - 项目类别:
Additional informatics support on U54 Clinical Core
U54 临床核心的附加信息学支持
- 批准号:
10685724 - 财政年份:2020
- 资助金额:
$ 75.72万 - 项目类别:
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