Kansas PKD Research and Translation Core Center

堪萨斯 PKD 研究与翻译核心中心

• 批准号: 10475035
• 负责人: DARREN P. WALLACE
• 金额: $ 75.72万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10475035
• 关键词: Autosomal Dominant Polycystic Kidney; Basic Science; Biochemistry; Biocompatible Materials; Biological Markers; Biomedical Research; Cancer Center; Cell model; Cell physiology; Cellular biology; Clinical; Clinical Research; Clinical Trials; Clinical Trials Network; Collaborations; Communities; Cyst; Development; Disease; Drug Targeting; Educational workshop; Effectiveness; Environment; Foundations; Goals; Grant; Growth; Infrastructure; Institutes; Institution; Interdisciplinary Study; Kansas; Kidney; Medical center; Methods; Mission; Pathogenesis; Patient-Focused Outcomes; Patients; Polycystic Kidney Diseases; Reagent; Recording of previous events; Research; Research Methodology; Research Personnel; Research Support; Resource Sharing; Resources; Rodent Model; Series; Services; Site; Technology; Testing; Translations; Universities; base; biomarker discovery; clinical development; drug testing; educational atmosphere; improved; innovation; insight; inter-institutional; meetings; multidisciplinary; new technology; novel therapeutic intervention; novel therapeutics; patient oriented; programs; recruit; summer student; symposium; therapeutic target; tool; translational medicine

Project Summary – Overall The Kansas PKD Research and Translation Core Center (RTCC) is comprised of an Administrative Core and three innovative Biomedical Research Cores: Core 1: Biomarkers, Biomaterials, and Cellular Models; Core 2: Rodent Models & Drug Testing; and Core 3: Clinical Research. The Kansas RTCC also offers an Educational Enrichment Program and an internal Pilot Grant Program in partnership with the KU Cancer Center. The mission of the PKD Center is to promote PKD research by providing both innovative and essential reagents, biomaterials, and service to the national PKD research community for the advancement of our understanding of disease mechanisms, the discovery of biomarkers and therapeutic targets and the development of clinical trials to improve patient outcomes. The Specific Aims of the Kansas PKD RTCC are: Aim 1) To support PKD researchers nationally by developing innovative biomedical research cores. This will be accomplished by developing the expertise, reagents and resources required to bring the best new technologies to PKD research to meet the needs of the greater PKD research community; by leveraging existing institutional shared resources to expand our capability, efficiency, and effectiveness; and by developing tools to support clinical research and establish collaborations both regionally and nationally to develop a multi-institutional ADPKD clinical trials network. Aim 2) To develop a skilled, collaborative, multidisciplinary basic science and clinical PKD research investigator base. This will be accomplished by building on our broad multidisciplinary research base and continuing to recruit new investigators from outside the PKD field by offering an innovative pilot grant program that will attract new investigators to the field, and by providing new investigators, nationally, with research support for core services, new technologies, educational opportunities, and an open and collaborative research environment that will help them succeed. Aim 3) To enhance the PKD research environment with educational programs to support ongoing projects and to develop new research directions. The research environment will be enhanced through a seminar program, Summer Student Enrichment Program, PKD lab meetings, PKD methods workshops, Research Methods and Advanced Technologies Program, professional development seminar series, patient-oriented activities, and by participating in the consortium-wide annual symposium. Aim 4) To develop partnerships regionally and nationally and to build teams to serve as a resource for the greater PKD research community. Inter-institutional partnerships will provide local and national infrastructure support, new research technologies, increased numbers of patients involved in clinical trials, and research collaborators for the development of new research opportunities by attracting investigators from other fields into PKD research from collaborating sites within the PKD Research Consortium and with cooperating institutions nationwide, broadening opportunities beyond what any single institution can provide.

项目摘要--总体 堪萨斯州PKD研究和翻译核心中心(RTCC)由一个管理核心和 三个创新的生物医学研究核心：核心1：生物标志物、生物材料和细胞模型；核心2： 啮齿动物模型和药物测试；核心3：临床研究。堪萨斯州RTCC还提供了一项教育 与昆士兰州立大学癌症中心合作的增富计划和内部试点资助计划。这个 PKD中心的使命是通过提供创新和必要的试剂来促进PKD研究， 生物材料，并为国家PKD研究界提供服务，以促进我们的理解 疾病机制、生物标志物和治疗靶点的发现以及临床的发展 改善患者预后的试验。堪萨斯州PKD RTCC的具体目标是：目标1)支持PKD 通过开发创新的生物医学研究核心，在全国范围内开展研究。这将通过以下方式实现 开发为PKD研究带来最佳新技术所需的专业知识、试剂和资源 满足更大的PKD研究社区的需求；通过利用现有的机构共享 资源，以扩大我们的能力、效率和效力；并通过开发工具来支持临床 研究和建立区域和国家之间的合作，以发展多机构的联合国开发计划署 临床试验网络。目标2)发展熟练、协作、多学科的基础科学和临床 PKD研究调查员基地。这将通过我们广泛的多学科研究来实现 基地，并通过提供创新的试点赠款，继续从PKD领域以外征聘新的调查员 该计划将吸引新的调查人员进入该领域，并通过在全国范围内为新的调查人员提供 为核心服务、新技术、教育机会和开放协作的研究提供支持 将帮助他们取得成功的研究环境。目的3)通过以下方式加强PKD研究环境 支持正在进行的项目和开发新的研究方向的教育计划。这项研究 将通过PKD实验室的暑期学生充实计划研讨会计划来改善环境 会议、PKD方法研讨会、研究方法和高级技术计划、专业人员 发展研讨会系列，以患者为中心的活动，并通过参加全财团的年度 研讨会。目标4)在区域和国家发展伙伴关系，并建立团队，作为 为更大的PKD研究社区提供的资源。机构间伙伴关系将为地方和国家提供 基础设施支持、新的研究技术、参与临床试验的患者数量增加，以及 研究合作者通过吸引来自其他国家的研究人员来开发新的研究机会 从PKD研究联盟内的合作站点和与合作机构合作进入PKD研究领域 全国范围内的机构，拓宽了任何一家机构所能提供的机会。