Environmental Influences on Child Health Outcomes in Puerto Rico (ECHO-PRO)

环境对波多黎各儿童健康结果的影响 (ECHO-PRO)

• 批准号: 10475655
• 负责人: Akram N Alshawabkeh
• 金额: $ 311.84万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10475655
• 关键词: Address; Affect; Age; Air Pollution; Area; Aromatic Polycyclic Hydrocarbons; Biological; Birth; Birth Rate; Chemicals; Child; Child Development; Child Health; Childhood; Childhood Asthma; Clinical; Collaborations; Communication; Complex; Congenital Abnormality; Coupled; Data; Data Collection; Data Set; Development; Diet; Disease; Endocrine disruption; Environment; Environmental Engineering technology; Environmental Exposure; Environmental Health; Environmental Impact; Environmental Pollution; Environmental Risk Factor; Epidemiologist; Evaluation; Exposure to; Fetal Growth; Future; General Population; Hazardous Waste Sites; Health; Hispanic; Home; Infant; Inflammation; Infrastructure; Intervention; Knowledge; Measures; Mediator of activation protein; Medical Records; Metals; Michigan; Mothers; Motor; National Institute of Environmental Health Sciences; Obesity; Outcome; Oxidative Stress; Parabens; Particulate Matter; Pattern; Phenols; Policies; Poverty; Pregnancy; Pregnant Women; Premature Birth; Protocols documentation; Public Health; Puerto Rican; Puerto Rico; Questionnaires; Research; Respiratory Signs and Symptoms; Risk Assessment; Sampling; Scientist; Social Workers; Socioeconomic Status; Source; Speech; Standardization; Statistical Methods; Superfund; Testing; Underserved Population; Universities; Visit; adverse birth outcomes; autism spectrum disorder; base; cardiometabolism; cognitive ability; cohort; early childhood; environmental stressor; experience; fetal; follow-up; health disparity; improved; in utero; lung volume; maternal stress; multidisciplinary; neurodevelopment; novel; nutrition; obesity in children; pediatrician; phthalates; programs; psychosocial; recruit; respiratory health; sample collection; social; superfund site; toxicant; trend; volatile organic compound

PROJECT SUMMARY: Exposure to a complex mix of environmental stressors during critical fetal and childhood development periods is an important yet understudied area of public health, particularly when coupled with psychosocial and other factors that may modify the effects of these exposures. Existing studies usually investigate the effect of single toxicants or exposures and so do not reflect the reality that children experience combinations of exposures simultaneously. To address this gap, the proposed Environmental Influences on Child Health Outcomes in Puerto Rico (ECHO-PRO) will leverage and build upon an active birth cohort in Puerto Rico (“PROTECT”, P42ES017198) that has recently initiated infant/child follow-up (“CRECE”, P50ES026049). ECHO-PRO will provide data and biospecimens for 570 mother-child pairs already participating in the PROTECT/CRECE cohort, as well as recruit an additional 1100 pregnant women, yielding 990 more children, for a total of 1560 mother-child pairs (88% retention by completion of study) with data and biospecimens to be integrated into the ECHO Consortium. To accomplish this, we will use our established, proven PROTECT/CRECE infrastructure and our experience in recruitment, follow up, sample and data collection, management and analysis, to (a) recruit pregnant women, (b) collect and analyze biological samples during pregnancy, at birth and at annual child visits through age 5, and (c) collect detailed demographic, health, and exposure information collected through questionnaires, evaluations and medical record abstraction during pregnancy, at birth and at annual child visits through age 5. In addition, the multidisciplinary ECHO-PRO team will study (using novel statistical methods for analysis of mixtures) the impact of multiple environmental exposures and exposure mixtures; specifically the relationship between exposure (maternal, in utero and/or during early childhood) to common mixtures of environmental contaminants (air pollution, metals, polycyclic aromatic hydrocarbons, phthalates, phenols, parabens), as well as their mechanistic mediators and modifying factors, on the four ECHO outcome domains: (1) adverse birth outcomes, including preterm birth, reduced fetal growth, and birth defects, (2) obesity, including maternal gestational glycemia and measures of child adiposity and cardiometabolic health, (3) neurodevelopment, including measures of child personal-social, adaptive, motor, communication and cognitive abilities and (4) respiratory health, including measures of child cardiorespiratory patterning, lung volume, and respiratory symptoms. Finally, ECHO-PRO will integrate and compare data obtained through our cohort with the overall ECHO data to better understand the environmental influences on child health outcomes in Puerto Rico and the U.S. mainland.

项目总结：在关键的胎儿和胎儿期暴露于复杂的环境应激源， 儿童发育期是公共卫生的一个重要但研究不足的领域，特别是当 再加上心理社会因素和其他因素，可能会改变这些接触的影响。现有研究 通常调查单一毒物或暴露的影响，因此不能反映儿童 同时经历多种暴露。 为了弥补这一差距，拟议的波多黎各环境对儿童健康结果的影响 （ECHO-PRO）将利用和建立在波多黎各的活跃出生队列（“ABT”，P42 ES 017198） 最近启动了婴儿/儿童随访（“CRECE”，P50 ES 026049）。ECHO-PRO将提供数据， 已经参与CRT-T/CRECE队列的570对母子的生物标本，以及 再招募1 100名孕妇，多产990名婴儿，共计1 560对母婴 (88研究完成时的保留率%），数据和生物标本将整合到ECHO中 财团 为了实现这一目标，我们将利用我们已建立的、经过验证的CIMT/CRECE基础设施和我们的经验 在招募、跟踪、抽样和数据收集、管理和分析方面， 妇女，（B）在怀孕期间、分娩时和每年的儿童访问时收集和分析生物样品， 5岁，以及（c）收集详细的人口统计学，健康和暴露信息，通过 在怀孕期间、分娩时和每年的儿童访视时进行问卷调查、评估和医疗记录提取 直到5岁 此外，多学科ECHO-PRO团队将研究（使用新的统计分析方法 混合物）的影响，特别是多种环境接触和接触混合物的影响， 接触（母亲、子宫内和/或幼儿期）常见混合物之间的关系 环境污染物（空气污染、金属、多环芳烃、邻苯二甲酸盐， 酚类，对羟基苯甲酸酯），以及它们的机械介质和修饰因子，对四种ECHO 结果领域：（1）不良出生结果，包括早产、胎儿生长迟缓和分娩 缺陷，（2）肥胖，包括母亲妊娠期肥胖和儿童肥胖的措施， 心脏代谢健康，（3）神经发育，包括儿童个人-社会，适应，运动， 沟通和认知能力;（4）呼吸健康，包括儿童心肺功能的测量 模式、肺容量和呼吸道症状。最后，ECHO-PRO将整合和比较数据 通过我们的队列获得的整体ECHO数据，以更好地了解环境对 波多黎各和美国本土的儿童健康结果。