Environmental Influences on Child Health Outcomes in Puerto Rico (ECHO-PRO)

环境对波多黎各儿童健康结果的影响 (ECHO-PRO)

基本信息

  • 批准号:
    10475655
  • 负责人:
  • 金额:
    $ 311.84万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-09-21 至 2023-08-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY: Exposure to a complex mix of environmental stressors during critical fetal and childhood development periods is an important yet understudied area of public health, particularly when coupled with psychosocial and other factors that may modify the effects of these exposures. Existing studies usually investigate the effect of single toxicants or exposures and so do not reflect the reality that children experience combinations of exposures simultaneously. To address this gap, the proposed Environmental Influences on Child Health Outcomes in Puerto Rico (ECHO-PRO) will leverage and build upon an active birth cohort in Puerto Rico (“PROTECT”, P42ES017198) that has recently initiated infant/child follow-up (“CRECE”, P50ES026049). ECHO-PRO will provide data and biospecimens for 570 mother-child pairs already participating in the PROTECT/CRECE cohort, as well as recruit an additional 1100 pregnant women, yielding 990 more children, for a total of 1560 mother-child pairs (88% retention by completion of study) with data and biospecimens to be integrated into the ECHO Consortium. To accomplish this, we will use our established, proven PROTECT/CRECE infrastructure and our experience in recruitment, follow up, sample and data collection, management and analysis, to (a) recruit pregnant women, (b) collect and analyze biological samples during pregnancy, at birth and at annual child visits through age 5, and (c) collect detailed demographic, health, and exposure information collected through questionnaires, evaluations and medical record abstraction during pregnancy, at birth and at annual child visits through age 5. In addition, the multidisciplinary ECHO-PRO team will study (using novel statistical methods for analysis of mixtures) the impact of multiple environmental exposures and exposure mixtures; specifically the relationship between exposure (maternal, in utero and/or during early childhood) to common mixtures of environmental contaminants (air pollution, metals, polycyclic aromatic hydrocarbons, phthalates, phenols, parabens), as well as their mechanistic mediators and modifying factors, on the four ECHO outcome domains: (1) adverse birth outcomes, including preterm birth, reduced fetal growth, and birth defects, (2) obesity, including maternal gestational glycemia and measures of child adiposity and cardiometabolic health, (3) neurodevelopment, including measures of child personal-social, adaptive, motor, communication and cognitive abilities and (4) respiratory health, including measures of child cardiorespiratory patterning, lung volume, and respiratory symptoms. Finally, ECHO-PRO will integrate and compare data obtained through our cohort with the overall ECHO data to better understand the environmental influences on child health outcomes in Puerto Rico and the U.S. mainland.
项目总结:在关键的胎儿和胎儿期暴露于复杂的环境应激源, 儿童发育期是公共卫生的一个重要但研究不足的领域,特别是当 再加上心理社会因素和其他因素,可能会改变这些接触的影响。现有研究 通常调查单一毒物或暴露的影响,因此不能反映儿童 同时经历多种暴露。 为了弥补这一差距,拟议的波多黎各环境对儿童健康结果的影响 (ECHO-PRO)将利用和建立在波多黎各的活跃出生队列(“ABT”,P42 ES 017198) 最近启动了婴儿/儿童随访(“CRECE”,P50 ES 026049)。ECHO-PRO将提供数据, 已经参与CRT-T/CRECE队列的570对母子的生物标本,以及 再招募1 100名孕妇,多产990名婴儿,共计1 560对母子 (88研究完成时的保留率%),数据和生物标本将整合到ECHO中 财团 为了实现这一目标,我们将利用我们已建立的、经过验证的CIMT/CRECE基础设施和我们的经验 在招募、跟踪、抽样和数据收集、管理和分析方面, 妇女,(B)在怀孕期间、分娩时和每年的儿童访问时收集和分析生物样品, 5岁,以及(c)收集详细的人口统计学,健康和暴露信息,通过 在怀孕期间、分娩时和每年的儿童访视时进行问卷调查、评估和医疗记录提取 直到5岁 此外,多学科ECHO-PRO团队将研究(使用新的统计分析方法 混合物)的影响,特别是多种环境接触和接触混合物的影响, 接触(母亲、子宫内和/或幼儿期)常见混合物之间的关系 环境污染物(空气污染、金属、多环芳烃、邻苯二甲酸盐, 酚类,对羟基苯甲酸酯),以及它们的机械介质和修饰因子,对四种ECHO 结果领域:(1)不良出生结果,包括早产、胎儿生长迟缓和分娩 缺陷,(2)肥胖,包括母亲妊娠期肥胖和儿童肥胖的措施, 心脏代谢健康,(3)神经发育,包括儿童个人-社会,适应,运动, 沟通和认知能力;(4)呼吸系统健康,包括儿童心肺功能指标 模式、肺容量和呼吸道症状。最后,ECHO-PRO将整合和比较数据 通过我们的队列获得的整体ECHO数据,以更好地了解环境对 波多黎各和美国本土的儿童健康结果。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Akram N Alshawabkeh其他文献

Akram N Alshawabkeh的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Akram N Alshawabkeh', 18)}}的其他基金

Puerto Rico Testsite for Exploring Contamination Threats (PROTECT)
波多黎各探索污染威胁的试验场(PROTECT)
  • 批准号:
    10796254
  • 财政年份:
    2023
  • 资助金额:
    $ 311.84万
  • 项目类别:
Puerto Rico Testsite for Exploring Contamination Threats (PROTECT)
波多黎各探索污染威胁的试验场(PROTECT)
  • 批准号:
    10382024
  • 财政年份:
    2021
  • 资助金额:
    $ 311.84万
  • 项目类别:
Puerto Rico Testsite for Exploring Contamination Threats (PROTECT)
波多黎各探索污染威胁的试验场(PROTECT)
  • 批准号:
    10382038
  • 财政年份:
    2021
  • 资助金额:
    $ 311.84万
  • 项目类别:
Puerto Rico Testsite for Exploring Contamination Threats (PROTECT) - Admin Supplement
波多黎各探索污染威胁测试站 (PROTECT) - 管理补充
  • 批准号:
    10411854
  • 财政年份:
    2021
  • 资助金额:
    $ 311.84万
  • 项目类别:
Environmental Influences on Child Health Outcomes in Puerto Rico (ECHO-PRO)
环境对波多黎各儿童健康结果的影响 (ECHO-PRO)
  • 批准号:
    10475485
  • 财政年份:
    2016
  • 资助金额:
    $ 311.84万
  • 项目类别:
Environmental Influences on Child Health Outcomes in Puerto Rico (ECHO-PRO)
环境对波多黎各儿童健康结果的影响 (ECHO-PRO)
  • 批准号:
    10240280
  • 财政年份:
    2016
  • 资助金额:
    $ 311.84万
  • 项目类别:
ECHO-PROTECT Cohort Study Site in Puerto Rico
波多黎各 ECHO-PROTECT 队列研究基地
  • 批准号:
    10744904
  • 财政年份:
    2016
  • 资助金额:
    $ 311.84万
  • 项目类别:
Environmental Influences on Child Health Outcomes in Puerto Rico (ECHO-PRO)
环境对波多黎各儿童健康结果的影响 (ECHO-PRO)
  • 批准号:
    10013296
  • 财政年份:
    2016
  • 资助金额:
    $ 311.84万
  • 项目类别:
Environmental Influences on Child Health Outcomes in Puerto Rico (ECHO-PRO)
环境对波多黎各儿童健康结果的影响 (ECHO-PRO)
  • 批准号:
    10176882
  • 财政年份:
    2016
  • 资助金额:
    $ 311.84万
  • 项目类别:
Research Opportunities for Undergraduates: Training in Environmental Health Sciences (ROUTES)
本科生研究机会:环境健康科学培训(ROUTES)
  • 批准号:
    8912806
  • 财政年份:
    2015
  • 资助金额:
    $ 311.84万
  • 项目类别:

相似海外基金

Hormone therapy, age of menopause, previous parity, and APOE genotype affect cognition in aging humans.
激素治疗、绝经年龄、既往产次和 APOE 基因型会影响老年人的认知。
  • 批准号:
    495182
  • 财政年份:
    2023
  • 资助金额:
    $ 311.84万
  • 项目类别:
Investigating how alternative splicing processes affect cartilage biology from development to old age
研究选择性剪接过程如何影响从发育到老年的软骨生物学
  • 批准号:
    2601817
  • 财政年份:
    2021
  • 资助金额:
    $ 311.84万
  • 项目类别:
    Studentship
RAPID: Coronavirus Risk Communication: How Age and Communication Format Affect Risk Perception and Behaviors
RAPID:冠状病毒风险沟通:年龄和沟通方式如何影响风险认知和行为
  • 批准号:
    2029039
  • 财政年份:
    2020
  • 资助金额:
    $ 311.84万
  • 项目类别:
    Standard Grant
Neighborhood and Parent Variables Affect Low-Income Preschool Age Child Physical Activity
社区和家长变量影响低收入学龄前儿童的身体活动
  • 批准号:
    9888417
  • 财政年份:
    2019
  • 资助金额:
    $ 311.84万
  • 项目类别:
The affect of Age related hearing loss for cognitive function
年龄相关性听力损失对认知功能的影响
  • 批准号:
    17K11318
  • 财政年份:
    2017
  • 资助金额:
    $ 311.84万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
  • 批准号:
    9320090
  • 财政年份:
    2017
  • 资助金额:
    $ 311.84万
  • 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
  • 批准号:
    10166936
  • 财政年份:
    2017
  • 资助金额:
    $ 311.84万
  • 项目类别:
Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related Pathology
影响调节和 β 淀粉样蛋白:衰老和年龄相关病理学中的成熟因素
  • 批准号:
    9761593
  • 财政年份:
    2017
  • 资助金额:
    $ 311.84万
  • 项目类别:
How age dependent molecular changes in T follicular helper cells affect their function
滤泡辅助 T 细胞的年龄依赖性分子变化如何影响其功能
  • 批准号:
    BB/M50306X/1
  • 财政年份:
    2014
  • 资助金额:
    $ 311.84万
  • 项目类别:
    Training Grant
Inflamm-aging: What do we know about the effect of inflammation on HIV treatment and disease as we age, and how does this affect our search for a Cure?
炎症衰老:随着年龄的增长,我们对炎症对艾滋病毒治疗和疾病的影响了解多少?这对我们寻找治愈方法有何影响?
  • 批准号:
    288272
  • 财政年份:
    2013
  • 资助金额:
    $ 311.84万
  • 项目类别:
    Miscellaneous Programs
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了