Environmental Influences on Child Health Outcomes in Puerto Rico (ECHO-PRO)

环境对波多黎各儿童健康结果的影响 (ECHO-PRO)

• 批准号: 10475655
• 负责人: Akram N Alshawabkeh
• 金额: $ 311.84万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10475655
• 关键词: Address; Affect; Age; Air Pollution; Area; Aromatic Polycyclic Hydrocarbons; Biological; Birth; Birth Rate; Chemicals; Child; Child Development; Child Health; Childhood; Childhood Asthma; Clinical; Collaborations; Communication; Complex; Congenital Abnormality; Coupled; Data; Data Collection; Data Set; Development; Diet; Disease; Endocrine disruption; Environment; Environmental Engineering technology; Environmental Exposure; Environmental Health; Environmental Impact; Environmental Pollution; Environmental Risk Factor; Epidemiologist; Evaluation; Exposure to; Fetal Growth; Future; General Population; Hazardous Waste Sites; Health; Hispanic; Home; Infant; Inflammation; Infrastructure; Intervention; Knowledge; Measures; Mediator of activation protein; Medical Records; Metals; Michigan; Mothers; Motor; National Institute of Environmental Health Sciences; Obesity; Outcome; Oxidative Stress; Parabens; Particulate Matter; Pattern; Phenols; Policies; Poverty; Pregnancy; Pregnant Women; Premature Birth; Protocols documentation; Public Health; Puerto Rican; Puerto Rico; Questionnaires; Research; Respiratory Signs and Symptoms; Risk Assessment; Sampling; Scientist; Social Workers; Socioeconomic Status; Source; Speech; Standardization; Statistical Methods; Superfund; Testing; Underserved Population; Universities; Visit; adverse birth outcomes; autism spectrum disorder; base; cardiometabolism; cognitive ability; cohort; early childhood; environmental stressor; experience; fetal; follow-up; health disparity; improved; in utero; lung volume; maternal stress; multidisciplinary; neurodevelopment; novel; nutrition; obesity in children; pediatrician; phthalates; programs; psychosocial; recruit; respiratory health; sample collection; social; superfund site; toxicant; trend; volatile organic compound

PROJECT SUMMARY: Exposure to a complex mix of environmental stressors during critical fetal and childhood development periods is an important yet understudied area of public health, particularly when coupled with psychosocial and other factors that may modify the effects of these exposures. Existing studies usually investigate the effect of single toxicants or exposures and so do not reflect the reality that children experience combinations of exposures simultaneously. To address this gap, the proposed Environmental Influences on Child Health Outcomes in Puerto Rico (ECHO-PRO) will leverage and build upon an active birth cohort in Puerto Rico (“PROTECT”, P42ES017198) that has recently initiated infant/child follow-up (“CRECE”, P50ES026049). ECHO-PRO will provide data and biospecimens for 570 mother-child pairs already participating in the PROTECT/CRECE cohort, as well as recruit an additional 1100 pregnant women, yielding 990 more children, for a total of 1560 mother-child pairs (88% retention by completion of study) with data and biospecimens to be integrated into the ECHO Consortium. To accomplish this, we will use our established, proven PROTECT/CRECE infrastructure and our experience in recruitment, follow up, sample and data collection, management and analysis, to (a) recruit pregnant women, (b) collect and analyze biological samples during pregnancy, at birth and at annual child visits through age 5, and (c) collect detailed demographic, health, and exposure information collected through questionnaires, evaluations and medical record abstraction during pregnancy, at birth and at annual child visits through age 5. In addition, the multidisciplinary ECHO-PRO team will study (using novel statistical methods for analysis of mixtures) the impact of multiple environmental exposures and exposure mixtures; specifically the relationship between exposure (maternal, in utero and/or during early childhood) to common mixtures of environmental contaminants (air pollution, metals, polycyclic aromatic hydrocarbons, phthalates, phenols, parabens), as well as their mechanistic mediators and modifying factors, on the four ECHO outcome domains: (1) adverse birth outcomes, including preterm birth, reduced fetal growth, and birth defects, (2) obesity, including maternal gestational glycemia and measures of child adiposity and cardiometabolic health, (3) neurodevelopment, including measures of child personal-social, adaptive, motor, communication and cognitive abilities and (4) respiratory health, including measures of child cardiorespiratory patterning, lung volume, and respiratory symptoms. Finally, ECHO-PRO will integrate and compare data obtained through our cohort with the overall ECHO data to better understand the environmental influences on child health outcomes in Puerto Rico and the U.S. mainland.

项目摘要：在危急的胎儿和胎儿时期暴露于复杂的环境压力源中 儿童发育时期是公共卫生的一个重要但尚未得到充分研究的领域，特别是当 再加上可能改变这些暴露影响的心理社会因素和其他因素。现有研究 通常调查单一有毒物质或暴露的影响，因此不能反映儿童的现实情况 同时体验曝光组合。 为了解决这一差距，拟议的《环境对波多黎各儿童健康结果的影响》 (ECHO-PRO) 将利用波多黎各活跃的出生队列并以此为基础（“PROTECT”，P42ES017198） 最近启动了婴儿/儿童随访（“CRECE”，P50ES026049）。 ECHO-PRO 将提供数据和 已参与 PROTECT/CRECE 队列的 570 对母子的生物样本，以及 新增1100名孕妇，生育990名儿童，母子总数达到1560对 （完成研究后保留 88%），数据和生物样本将集成到 ECHO 中 财团。 为了实现这一目标，我们将利用我们已建立的、经过验证的 PROTECT/CRECE 基础设施和我们的经验 在招募、随访、样本和数据收集、管理和分析方面，以 (a) 招募孕妇 妇女，(b) 通过以下方式收集和分析怀孕期间、分娩时和每年儿童探访时的生物样本： 5 岁，并且 (c) 收集通过以下方式收集的详细人口统计、健康和暴露信息 怀孕期间、出生时和年度儿童就诊时的调查问卷、评估和病历摘要 到 5 岁。 此外，多学科 ECHO-PRO 团队将研究（使用新颖的统计方法进行分析） 混合物）多重环境暴露和暴露混合物的影响；特别是 接触常见混合物（母亲、子宫内和/或幼儿期）之间的关系 环境污染物（空气污染、金属、多环芳烃、邻苯二甲酸盐、 苯酚、对羟基苯甲酸酯）及其机械介质和调节因子，对四种 ECHO 结局领域：（1）不良分娩结局，包括早产、胎儿生长迟缓和分娩 缺陷，（2）肥胖，包括母亲妊娠血糖和儿童肥胖的测量和 心脏代谢健康，(3) 神经发育，包括儿童个人社交、适应性、运动、 沟通和认知能力以及（4）呼吸系统健康，包括儿童心肺功能的测量 模式、肺容量和呼吸道症状。最后，ECHO-PRO会对数据进行整合和比较 通过我们的队列获得整体 ECHO 数据，以更好地了解环境对 波多黎各和美国大陆的儿童健康结果。