Environmental Influences on Child Health Outcomes in Puerto Rico (ECHO-PRO)

环境对波多黎各儿童健康结果的影响 (ECHO-PRO)

• 批准号: 10475485
• 负责人: Akram N Alshawabkeh
• 金额: $ 11.09万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10475485
• 关键词: Address; Affect; Age; Air Pollution; Area; Aromatic Polycyclic Hydrocarbons; Biological; Birth; Birth Rate; Chemicals; Child; Child Development; Child Health; Childhood; Childhood Asthma; Clinical; Collaborations; Communication; Complex; Congenital Abnormality; Coupled; Data; Data Collection; Data Set; Development; Diet; Disease; Endocrine disruption; Environment; Environmental Engineering technology; Environmental Exposure; Environmental Health; Environmental Impact; Environmental Pollution; Environmental Risk Factor; Epidemiologist; Evaluation; Exposure to; Fetal Growth; Future; General Population; Hazardous Waste Sites; Health; Hispanics; Home; Infant; Inflammation; Infrastructure; Intervention; Knowledge; Measures; Mediator of activation protein; Medical Records; Metals; Michigan; Mothers; Motor; National Institute of Environmental Health Sciences; Obesity; Outcome; Oxidative Stress; Parabens; Particulate Matter; Pattern; Phenols; Policies; Poverty; Pregnancy; Pregnant Women; Premature Birth; Protocols documentation; Public Health; Puerto Rican; Puerto Rico; Questionnaires; Research; Respiratory Signs and Symptoms; Risk Assessment; Sampling; Scientist; Social Workers; Socioeconomic Status; Source; Speech; Standardization; Statistical Methods; Superfund; Testing; Underserved Population; Universities; Visit; adverse birth outcomes; autism spectrum disorder; base; cardiometabolism; cognitive ability; cohort; early childhood; environmental stressor; experience; fetal; follow-up; health disparity; improved; in utero; lung volume; maternal stress; multidisciplinary; neurodevelopment; novel; nutrition; obesity in children; pediatrician; phthalates; programs; psychosocial; recruit; respiratory health; sample collection; social; superfund site; toxicant; trend; volatile organic compound

PROJECT SUMMARY: Exposure to a complex mix of environmental stressors during critical fetal and childhood development periods is an important yet understudied area of public health, particularly when coupled with psychosocial and other factors that may modify the effects of these exposures. Existing studies usually investigate the effect of single toxicants or exposures and so do not reflect the reality that children experience combinations of exposures simultaneously. To address this gap, the proposed Environmental Influences on Child Health Outcomes in Puerto Rico (ECHO-PRO) will leverage and build upon an active birth cohort in Puerto Rico (“PROTECT”, P42ES017198) that has recently initiated infant/child follow-up (“CRECE”, P50ES026049). ECHO-PRO will provide data and biospecimens for 570 mother-child pairs already participating in the PROTECT/CRECE cohort, as well as recruit an additional 1100 pregnant women, yielding 990 more children, for a total of 1560 mother-child pairs (88% retention by completion of study) with data and biospecimens to be integrated into the ECHO Consortium. To accomplish this, we will use our established, proven PROTECT/CRECE infrastructure and our experience in recruitment, follow up, sample and data collection, management and analysis, to (a) recruit pregnant women, (b) collect and analyze biological samples during pregnancy, at birth and at annual child visits through age 5, and (c) collect detailed demographic, health, and exposure information collected through questionnaires, evaluations and medical record abstraction during pregnancy, at birth and at annual child visits through age 5. In addition, the multidisciplinary ECHO-PRO team will study (using novel statistical methods for analysis of mixtures) the impact of multiple environmental exposures and exposure mixtures; specifically the relationship between exposure (maternal, in utero and/or during early childhood) to common mixtures of environmental contaminants (air pollution, metals, polycyclic aromatic hydrocarbons, phthalates, phenols, parabens), as well as their mechanistic mediators and modifying factors, on the four ECHO outcome domains: (1) adverse birth outcomes, including preterm birth, reduced fetal growth, and birth defects, (2) obesity, including maternal gestational glycemia and measures of child adiposity and cardiometabolic health, (3) neurodevelopment, including measures of child personal-social, adaptive, motor, communication and cognitive abilities and (4) respiratory health, including measures of child cardiorespiratory patterning, lung volume, and respiratory symptoms. Finally, ECHO-PRO will integrate and compare data obtained through our cohort with the overall ECHO data to better understand the environmental influences on child health outcomes in Puerto Rico and the U.S. mainland.

项目概述：在胎儿和胎儿关键期暴露于复杂的环境压力源