Environmental Influences on Child Health Outcomes in Puerto Rico (ECHO-PRO)

环境对波多黎各儿童健康结果的影响 (ECHO-PRO)

• 批准号: 10176882
• 负责人: Akram N Alshawabkeh
• 金额: $ 12.22万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10176882
• 关键词: 37 weeks gestation; Affect; Area; Award; Biological; Biological Markers; Birth; Brain; Chemicals; Child; Child Health; Clinical; Collaborations; Data; Development; Elements; Environment; Environmental Exposure; Environmental Health; Exposure to; Future; General Population; Infrastructure; Intervention; Knowledge; National Institute of Environmental Health Sciences; Outcome; Particulate Matter; Phenols; Policies; Population; Pregnant Women; Premature Birth; Public Health; Puerto Rico; Research; Risk Assessment; Sampling; Superfund; Testing; Underserved Population; United States Environmental Protection Agency; cohort; early childhood; fetal; follow up assessment; follow-up; neurodevelopment; phthalates; programs; recruit; reproductive; respiratory; volatile organic compound

Project Summary (UH3) The Environmental Influences on Child Health Outcomes in Puerto Rico (ECHO‐PRO) project leverages an active birth cohort in Puerto Rico (PROTECT cohort) that has initiated child follow‐up (CRECE cohort) to better understand environmental exposures and their effects on birth outcomes and children's health in Puerto Rico – an underserved, highly exposed population. “Puerto Rico Testsite for Exploring Contamination Threats (PROTECT)” is an NIEHS Superfund Research Program (SRP) cohort that started recruiting in 2011 and will continue through 2019 (P42ES017198). PROTECT tests the hypothesis that exposure to phthalates and chlorinated volatile organic compounds (CVOCs) contributes to the unusually high rate of preterm birth (<37 weeks gestation) in Puerto Rico. The “Center for Research on Early Childhood Exposure and Development in Puerto Rico (CRECE),” a Children's Environmental Health Center (CEHC), awarded jointly by NIEHS and the Environmental Protection Agency (EPA) in 2015 (P50ES026049), follows up on children born in the PROTECT cohort. CRECE is studying the impact of exposures to particulate matter and phenols and modifying factors on physical, reproductive and neurodevelopment among children in northern Puerto Rico. ECHO‐PRO will leverage the PROTECT/CRECE cohort (570 children at birth) and infrastructure, and recruit an additional 1100 pregnant women (100 in the UG3 and 1000 in the UH3) and their children (estimated N=990 at birth) collecting ECHO‐Wide approved elements for follow‐up assessments, repeated information on their environmental exposures, biomarkers of intermediate effect, and respiratory, physical, reproductive, and brain development.

项目总结(UH3) 波多黎各环境对儿童健康结果的影响(ECHO-PRO)项目杠杆 波多黎各活跃的出生队列(保护队列)，已启动儿童随访(CRECE队列) 更好地了解环境暴露及其对分娩结局和儿童健康的影响 在波多黎各，这是一个服务不足、高度暴露的人群。“波多黎各探险考察站 污染威胁(保护)“是NIEHS超级基金研究计划(SRP)的一个队列，始于 2011年将进行招聘，并将持续到2019年(P42ES017198)。PROTECT检验了假设 接触邻苯二甲酸盐和氯化挥发性有机化合物(CVOCs)会导致 波多黎各异常高的早产率(妊娠37周)。“研究中心” 波多黎各的儿童早期接触和发展(CRECE)，“儿童的环境健康” 中心(CEHC)，由NIEHS和环境保护局(EPA)于2015年联合授予 (P50ES026049)，对在保护队列中出生的儿童进行了跟踪。Crece正在研究 接触颗粒物和酚及其修饰因素对身体、生殖和健康的影响 波多黎各北部儿童的神经发育。ECHO-PRO将利用 保护/保护队列(570名出生时儿童)和基础设施，并额外招募1100人 孕妇(UG3州100名，UH3州1000名)及其子女(出生时估计N=990人) 收集全回声范围的经批准的后续评估要素，反复提供关于其 环境暴露，中等影响的生物标记物，以及呼吸，物理，生殖， 和大脑发育。