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ECHO-PROTECT Cohort Study Site in Puerto Rico

波多黎各 ECHO-PROTECT 队列研究基地

基本信息

批准号：
10744904
负责人：
Akram N Alshawabkeh
金额：
$ 490.01万
依托单位：
NORTHEASTERN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-21 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10744904
关键词：
Adaptive Behaviors Adolescence Affect Area Biological Biological Markers Birth Brain Chemical Exposure Chemicals Child Child Development Child Health Childhood Clinical Cognition Cohort Studies Collaborations Communication Conceptions Coupled Data Data Element Development Diet Discrimination Education Emotional Environmental Exposure Exposure to Flame Retardants Future General Population Goals Health Hormones Household Income Individual Infant Inflammation Intervention Knowledge Language Lead Life Measures Mediating Metals Minority Groups Mission Modification Mothers Motor Nature Neighborhoods Obesity Occupations Outcome Outcome Study Oxidative Stress Parabens Participant Patient Recruitments Persons Pesticides Phase Phenols Policies Population Population Heterogeneity Poverty Pregnancy Pregnancy Outcome Protocols documentation Puberty Public Health Puerto Rico Questionnaires Research Risk Assessment Role Sample Size Sampling Science Site Statistical Methods Testing Underserved Population Unhealthy Diet Weight Weight Gain anogenital distance cohort early childhood environmental chemical environmental chemical exposure epigenomics experience feeding follow-up girls health care availability in utero infancy innovation maternal obesity maternal weight metabolomics middle childhood mother nutrition multidisciplinary neurodevelopment obesity in pregnancy phthalates pregnant programs recruit reproductive reproductive development response social social disparities social health determinants

项目摘要

PROJECT SUMMARY The effect of early environmental exposures on child health and development is an important area of public health that no single cohort, or even a few, can answer alone – particularly when coupled with social determinants of health (SDOH) that may influence these exposures and modify their effects. Determining this effect becomes more challenging when considering that these exposures influence multiple interrelated health outcomes such as obesity, neurodevelopment and reproductive development. The ECHO-PROTECT Cohort Site in Puerto Rico (PR) will focus on these health outcomes, taking advantage of the rich and large sample size, diversity, and longitudinal nature of the national ECHO Cohort and multi-disciplinary expertise across the ECHO consortium. ECHO-PROTECT will contribute innovative research to (Aim 1) examine the influence of SDOH on maternal diet and obesity during pregnancy, child diet and obesity during early to middle childhood, and the relationship between maternal-child diet and onset of puberty and (Aim 2) determine the relationship between in utero and early childhood exposure to environmental chemicals, individually and as mixtures, and neurodevelopment and reproductive development, across early childhood, middle childhood, and adolescence. Most importantly, ECHO-PROTECT will build upon the ongoing ECHO-PROTECT cohort in PR (Aim 3) to follow up and collect data and biospecimens from the 1,100 children that are participating in the current ECHO- PROTECT cohort, as well as recruit an additional 1,200 pregnant participants, yielding 1,000 more children, for a total of 2,100 children contributing data and biospecimens to the ECHO Cohort from Puerto Rico – an underserved, highly-exposed population. The proposed 1,200 new pregnancies will include at least 125 completed pregnancies with preconception data (Aim 4), tracked from a cohort of 500 potential preconception participants and, if available, their conceiving partner. ECHO-PROTECT research will contribute meaningfully to ECHO’s mission, offering (a) an important cohort that will enrich consortium wide data, (b) significant, innovative science on the influence of SDOH and exposure to multiple chemicals on multiple interrelated health outcomes such as obesity, neurodevelopment, and reproductive development, and (c) expertise to lead and participate in additional new scientific directions involving biomarkers of exposure or biologic response, child brain or reproductive development, and statistical methods in collaboration with the ECHO consortium, to answer impactful and cutting-edge research questions. Results from our study will inform future clinical intervention, risk assessment and policy-setting efforts, with direct relevance to both the underserved population of Puerto Rico and the U.S. general population.

项目总结