ECHO-PROTECT Cohort Study Site in Puerto Rico

波多黎各 ECHO-PROTECT 队列研究基地

• 批准号: 10744904
• 负责人: Akram N Alshawabkeh
• 金额: $ 490.01万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10744904
• 关键词: Adaptive Behaviors; Adolescence; Affect; Area; Biological; Biological Markers; Birth; Brain; Chemical Exposure; Chemicals; Child; Child Development; Child Health; Childhood; Clinical; Cognition; Cohort Studies; Collaborations; Communication; Conceptions; Coupled; Data; Data Element; Development; Diet; Discrimination; Education; Emotional; Environmental Exposure; Exposure to; Flame Retardants; Future; General Population; Goals; Health; Hormones; Household; Income; Individual; Infant; Inflammation; Intervention; Knowledge; Language; Lead; Life; Measures; Mediating; Metals; Minority Groups; Mission; Modification; Mothers; Motor; Nature; Neighborhoods; Obesity; Occupations; Outcome; Outcome Study; Oxidative Stress; Parabens; Participant; Patient Recruitments; Persons; Pesticides; Phase; Phenols; Policies; Population; Population Heterogeneity; Poverty; Pregnancy; Pregnancy Outcome; Protocols documentation; Puberty; Public Health; Puerto Rico; Questionnaires; Research; Risk Assessment; Role; Sample Size; Sampling; Science; Site; Statistical Methods; Testing; Underserved Population; Unhealthy Diet; Weight; Weight Gain; anogenital distance; cohort; early childhood; environmental chemical; environmental chemical exposure; epigenomics; experience; feeding; follow-up; girls; health care availability; in utero; infancy; innovation; maternal obesity; maternal weight; metabolomics; middle childhood; mother nutrition; multidisciplinary; neurodevelopment; obesity in pregnancy; phthalates; pregnant; programs; recruit; reproductive; reproductive development; response; social; social disparities; social health determinants

PROJECT SUMMARY The effect of early environmental exposures on child health and development is an important area of public health that no single cohort, or even a few, can answer alone – particularly when coupled with social determinants of health (SDOH) that may influence these exposures and modify their effects. Determining this effect becomes more challenging when considering that these exposures influence multiple interrelated health outcomes such as obesity, neurodevelopment and reproductive development. The ECHO-PROTECT Cohort Site in Puerto Rico (PR) will focus on these health outcomes, taking advantage of the rich and large sample size, diversity, and longitudinal nature of the national ECHO Cohort and multi-disciplinary expertise across the ECHO consortium. ECHO-PROTECT will contribute innovative research to (Aim 1) examine the influence of SDOH on maternal diet and obesity during pregnancy, child diet and obesity during early to middle childhood, and the relationship between maternal-child diet and onset of puberty and (Aim 2) determine the relationship between in utero and early childhood exposure to environmental chemicals, individually and as mixtures, and neurodevelopment and reproductive development, across early childhood, middle childhood, and adolescence. Most importantly, ECHO-PROTECT will build upon the ongoing ECHO-PROTECT cohort in PR (Aim 3) to follow up and collect data and biospecimens from the 1,100 children that are participating in the current ECHO- PROTECT cohort, as well as recruit an additional 1,200 pregnant participants, yielding 1,000 more children, for a total of 2,100 children contributing data and biospecimens to the ECHO Cohort from Puerto Rico – an underserved, highly-exposed population. The proposed 1,200 new pregnancies will include at least 125 completed pregnancies with preconception data (Aim 4), tracked from a cohort of 500 potential preconception participants and, if available, their conceiving partner. ECHO-PROTECT research will contribute meaningfully to ECHO’s mission, offering (a) an important cohort that will enrich consortium wide data, (b) significant, innovative science on the influence of SDOH and exposure to multiple chemicals on multiple interrelated health outcomes such as obesity, neurodevelopment, and reproductive development, and (c) expertise to lead and participate in additional new scientific directions involving biomarkers of exposure or biologic response, child brain or reproductive development, and statistical methods in collaboration with the ECHO consortium, to answer impactful and cutting-edge research questions. Results from our study will inform future clinical intervention, risk assessment and policy-setting efforts, with direct relevance to both the underserved population of Puerto Rico and the U.S. general population.

项目摘要 早期环境暴露对儿童健康和发展的影响是公众的重要领域 没有任何单一的队列甚至少数人可以单独回答的健康 - 尤其是与社交相结合的 健康的决定因素（SDOH）可能会影响这些暴露并改变其影响。确定这一点 当考虑这些暴露会影响多个相互关联的健康时，效果变得更加挑战 肥胖，神经发育和生殖发展等结果。回声保护队列 波多黎各（PR）的地点将利用富裕和大型样本来关注这些健康成果 国家回声队列的规模，多样性和纵向性质和多学科专业知识 回声财团。 Echo Protect将为（目标1）贡献创新研究 SDOH关于怀孕期间的孕产妇饮食和肥胖症，儿童饮食和肥胖症的早期饮食和肥胖症， 以及孕产妇饮食与青春期发作和（AIM 2）确定关系之间的关系 在子宫内和幼儿期之间，个人和作为混合物的环境化学物质，以及 整个幼儿，中年和青少年的神经发育和生殖发展。 最重要的是，Echo保护将建立在PR中正在进行的Echo Protect队列的基础上（AIM 3） 跟进并收集来自1,100名参与当前回声的儿童的数据和生物测量 保护队列，并招募另外1200名怀孕参与者，育有1,000名儿童 来自波多黎各的回声队列的总共2100名儿童为数据和生物测量贡献了生物测量 -​​ 服务不足，暴露高度的人口。拟议的1200个新怀孕将至少包括125个 通过孕前数据（AIM 4）完成的怀孕 参与者，如果有的话，他们的构思合作伙伴。 Echo保护研究将为Echo的使命做出有意义的贡献，提供（a）重要的队列 这将丰富联盟广泛的数据，（b）关于SDOH和SDOH影响的重要，创新的科学 暴露于多种相互关联的健康结果（例如肥胖，神经发育）上的多种化学物质 和生殖发展，以及（c）领导和参与其他新科学方向的专业知识 涉及暴露或生物反应，儿童大脑或繁殖发育以及统计的生物标志物 与回声财团合作的方法，以回答有影响力的尖端研究问题。 我们研究的结果将为未来的临床干预，风险评估和政策制定工作提供依据，并通过 与服务不足的波多黎各和美国一般人口的直接相关性。