Core 2: Biocomputational and Biostatistics Core

项目概要/摘要-核心2生物计算和生物统计学 核心2生物计算和生物统计的目的是提供计算和统计支持 本P01中的四个项目，并与核心合作，提供解决此类计算和 生物统计需要，以适应项目的需要。这保证了设计， 所有实验的进行和分析-临床的，相关的，动物的，或基础科学-使用稳健的统计 适当实施的技术，以及用于分析和解释的专门资源 单细胞RNA测序结果优先提供给项目，用于临床试验细胞 患者，从这些患者开发的细胞系，并从小鼠实验。这一核心资源 从而有助于阐明T细胞活化和衰减的变化， GBM的干预措施。

PROJECT SUMMARY/ABSTRACT—Core 2 Biocomputation and Biostatistics The purpose of Core 2 Biocomputation and Biostatistics is to provide computational and statistical support to the four Projects in this P01, and to collaborate with Cores to provide to address such computational and biostatistical needs as required to accommodate the needs of the projects. This assures that the design, conduct, and analyses of all experiments—clinical, correlative, animal, or basic science--use robust statistical techniques that are appropriately implemented, and that the specialized resources to analyze and interpret single cell RNA sequencing results are available to the projects on a priority basis, for cells from clinical trial patients, from cell lines developed from those patients, and from murine experiments.. This central resource thereby helps to elucidate the changes in T cell activation and attenuation that result from immunologic interventions in GBM.