Biostatistics Core

项目摘要/摘要 核心C生物统计的目的是为本次P01中的所有项目提供统计支持。对于 临床结果与推测的遗传或甲基化驱动因素的新发现或新的 反映基因通路或网络的样本，在项目1中，核心将组装和管理临床 由内部和外部协作者提供的数据，并对这些数据之间的关联进行所有分析 新的发现和适当的临床参数。对于项目2和项目3的所有实验室和动物研究， 这包括确保使用稳健的统计方法设计、实施和分析实验 适当实施的技术。对于通过项目3执行的DBP研究，核心将 允许项目3在执行分析时对临床结果保持盲目，并将评估 代表项目3的分析的预测能力。通过这些目标，项目的中心资源 将协调实验室内部的相互作用，以实现识别CLL基因组的新方面和 物候组及其与患者预后的关系。

Project Summary/Abstract The purpose of Core C Biostatistics is to provide statistical support to all the Projects in this P01. For the association of clinical outcome with novel findings of putative genetic or methylation drivers, or new clusters of samples reflecting gene pathways or networks, in Project 1, the Core will assemble and curate the clinical data provided by internal and external collaborators, and perform all analyses of association between these novel findings and appropriate clinical parameters. For all laboratory and animal studies of Projects 2 and 3, this includes assurance that the design, conduct, and analysis of experiments using robust statistical techniques that are appropriately implemented. For DBP studies performed through Project 3, the Core will permit Project 3 to remain blinded to clinical outcomes when performing their assays, and will assess the predictive ability of the assay on behalf of Project 3. Through these aims, this central resource for the Projects will coordinate intra-lab interactions to meet the goal of identifying novel aspects of the CLL genome and phenome and their associations with patient outcome.