Biostatistics

项目概要/摘要 核心4生物统计的目的是为本P01中的所有项目提供统计支持。为 临床结果与Richter综合性分子和蛋白质组解剖之间的关系 综合征（RS），如项目1所执行的，核心将收集和整理由以下人员提供的临床数据： 内部和外部的合作者，并进行所有的分析，这些新的发现之间的关联， 适当的临床参数。这将包括与项目密切合作，在cfDNA中评估任何RS特异性 这些变化可能预示着这种转变。对于项目2和3的所有实验室和动物研究， 核心将确保实验的设计、实施和分析使用稳健的统计技术， 适当执行。对于项目2，这包括肿瘤内源性和肿瘤特异性单细胞分析。 外在特征，以及这些特征的纵向评估。小鼠发生RS 将评估常见CLL突变组合（通过本P01生成）的缓解情况， 对新疗法的耐药性，并由本核心进行分析。DBP研究通过项目3进行， 使用临床关联核心将允许项目3对临床结局保持盲态， 执行他们的分析，确保他们的预测能力的公正评估。通过这些目标， 项目的中心资源将协调我们对从CLL到RS的轨迹的见解，并支持我们的 能够确定合理和个性化的治疗策略，为患者提供更好的机会， 疗方

Project Summary/Abstract The purpose of Core 4 Biostatistics is to provide statistical support to all the Projects in this P01. For the association between clinical outcome and the comprehensive molecular and proteomic dissection of Richter's syndrome (RS), as performed by Project 1, the Core will assemble and curate the clinical data provided by internal and external collaborators and perform all analyses of association between these novel findings and appropriate clinical parameters. This will include working closely with Project to assess in cfDNA any RS-specific alternations that may predict this transformation. For all laboratory and animal studies of Projects 2 and 3, the Core will assure that the design, conduct, and analysis of experiments use robust statistical techniques that are appropriately implemented. For Project 2 this includes the single cell analyses of the tumor-intrinsic and tumor- extrinsic features, as well as the longitudinal assessment of these features. The mice developing RS with combinations of common CLL mutations (generated through this P01) will be assessed for response and resistance to novel therapies and analyzed by this Core. DBP studies are performed through Project 3, and the use of the Core for clinical association will permit Project 3 to remain blinded to clinical outcomes when performing their assays, assuring an unbiased assessment of their predictive ability. Through these aims, this central resource for the Projects will coordinate our insights into the trajectories from CLL to RS and support our ability to identify rational and personalized therapeutic strategies that will offer patients an improved chance of cure.