Biostatistics and Bioinformatics Core

这项应用中研究项目的目的是提高我们对胸腺白血病和淋巴瘤的分子途径以及这些途径如何相互作用的理解。许多拟议的实验涉及操纵小鼠品系的基因表达，并探索其对其他基因表达的改变以及对动物胸腺疾病的发生率和时间的影响。预计这五个项目的成果将相互通报。项目成果将在生物统计核心成员的协助下传达给该方案的其他成员。这个 生物统计核心将协助该计划中包含的所有研究项目。 生物统计核心(核心B)的目的是提供以下服务，这些服务将被本计划项目中包括的研究项目所利用。 1.为项目2、3和4提供动物研究的生物统计合作，包括这些研究的实验室组成部分。这将包括此类研究的设计和分析的所有方面。 2.为项目1和5中在细胞系和小鼠样本上进行的实验室研究提供生物统计学支持。

The objective of the research projects in this application is to improve our understanding of the molecular pathways to thymic leukemia and lymphoma, and how these pathways interact. Many of the proposed experiments involve manipulating gene expression in strains of mice, and exploring the consequences both in terms of alteration of expression of other genes and on the incidence and timing of thymic disease in the animals. It is anticipated that the results of these five projects will inform one another. Project results will be conveyed to other members of the program with the assistance of members of the Biostatistics Core. The Biostatistics Core will assist all the research projects contained in this program. The purpose of the Biostatistics Core, Core B, is to provide the following services that will be utilized by the research projects included in this Program Project. 1. To provide biostatistical collaboration for animal studies, including the laboratory components of those studies, for Projects 2, 3, and 4. This will include all aspects of the design and analysis of such studies. 2. To provide biostatistical support for the laboratory studies conducted in cell lines and on murine samples in Projects 1 and 5.