Biostatistics

项目总结(见说明)： 核心B(生物统计学) 生物统计核心(核心B)力求确保所有儿童权利委员会调查人员在其调查设计和实施的所有方面都能获得最先进的生物统计学支持。 具体目标1：为CLL研究联盟(CRC)成员开展的调查提供协作统计支助 1.1为研究中心进行的临床研究提供统计支援。 1.2为研究中心进行的实验室研究提供统计支援，包括项目内的独立研究和临床试验内的实验室相关研究。 1.3为项目进行的小鼠研究提供统计支持。 具体目标2：参加儿童权利委员会数据库的质量保证和质量改进进程 2.1参加儿童权利委员会数据库的持续质量改进进程。 2.2随着新类型数据纳入儿童权利中心数据库，就质量保证问题提供意见。 具体目标3；参加儿童权利委员会的科学咨询委员会 3.1参加临床咨询委员会、科学咨询委员会和数据安全与监测委员会举行的电话会议和会议。 3.2参加对提交给组织核心(核心C)的所有样本请求的审查。 具体目标4：为从事CLL工作的统计学家提供一个论坛 4.1通过分布式生物统计核心，为从事CLL工作的统计员提供一个论坛，以增进他们对疾病的了解，从而为项目提供更好的统计支持。

PROJECT SUMMARY (See instructions): CORE B (Biostatistics) The Biostatistics Core (Core B) seeks to assure that all CRC investigators have access to state-of-the-art biostatistical support for all aspects of the design and conduct of their investigations. Specific Aim 1: To provide collaborative statistical support for investigations conducted by the members of the CLL Research Consortium (CRC) 1.1 To provide statistical support for the clinical research studies conducted by the CRC. 1.2 To provide statistical support for the laboratory studies conducted by the CRC, including both freestanding studies within the Projects and laboratory correlative studies embedded in the clinical trials. 1.3 To provide statistical support for murine studies conducted by the Projects. Specific Aim 2: To participate in the quality assurance and quality improvement processes for the CRC database 2.1 To participate in an ongoing process of quality improvement for the CRC database. 2.2 To advise on quality assurance as new types of data are incorporated into the CRC database. Specific Aim 3; To participate in the scientific advisory committees of the CRC 3.1 To participate in teleconferences and meetings held by the Clinical Advisory Committee, the Scientific Advisory Committee, and the Data Safety and Monitoring Board. 3.2 To participate in the review of all sample requests submitted to the Tissue Core (Core C). Specific Aim 4: To provide a forum for statisticians working in CLL 4.1 To provide, through the distributed Biostatistics Core, a forum for statisticians working in CLL to improve their understanding of the disease and thereby provide even better statistical support to the Projects.