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Core 2: Biocomputational and Biostatistics Core

核心2：生物计算和生物统计学核心

基本信息

批准号：
10210227
负责人：
DONNA S. NEUBERG
金额：
$ 21.64万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-03 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10210227
关键词：
Address Algorithms Animal Experiments Animal Model Animals B-Lymphocytes Basic Science Biological Assay Biometry Biostatistics Core Cell Communication Cell Line Cell Nucleus Cells Clinical Clinical Research Clinical Trials Clonality Clone Cells Correlative Study Data Data Analyses Ensure Experimental Designs Genes Genetic Genetic Variation Genomics Glioblastoma Goals Human Immunosuppression Immunotherapy Individual Intervention Investigation Laboratories Lead Maps Measurement Mus Noise Non-Malignant Patients Peer Review Physiological Process Reproducibility Resources Scheme Specimen T-Cell Activation T-Lymphocyte Techniques Variant Visualization Work attenuation biocomputing cell type clinically relevant computational pipelines computerized data processing data sharing design experimental study genetic manipulation human data immunological intervention insight laboratory experiment mouse model power analysis predicting response profiles in patients programs single-cell RNA sequencing transcriptome sequencing treatment response tumor tumor-immune system interactions

项目摘要

PROJECT SUMMARY/ABSTRACT—Core 2 Biocomputation and Biostatistics The purpose of Core 2 Biocomputation and Biostatistics is to provide computational and statistical support to the four Projects in this P01, and to collaborate with Cores to provide to address such computational and biostatistical needs as required to accommodate the needs of the projects. This assures that the design, conduct, and analyses of all experiments—clinical, correlative, animal, or basic science--use robust statistical techniques that are appropriately implemented, and that the specialized resources to analyze and interpret single cell RNA sequencing results are available to the projects on a priority basis, for cells from clinical trial patients, from cell lines developed from those patients, and from murine experiments.. This central resource thereby helps to elucidate the changes in T cell activation and attenuation that result from immunologic interventions in GBM.

项目概要/摘要-核心2生物计算和生物统计学核心2生物计算和生物统计的目的是提供计算和统计支持本P01中的四个项目，并与核心合作，提供解决此类计算和生物统计需要，以适应项目的需要。这保证了设计，所有实验的进行和分析-临床的，相关的，动物的，或基础科学-使用稳健的统计适当实施的技术，以及用于分析和解释的专门资源单细胞RNA测序结果优先提供给项目，用于临床试验细胞患者，从这些患者开发的细胞系，并从小鼠实验。这一核心资源从而有助于阐明T细胞活化和衰减的变化， GBM的干预措施。