BIOSTATISTICS

本申请研究项目的最终目的是提高我们对 人类髓系白血病的发病机制，并探索与 正在调查的疾病途径。预计实验室和小鼠将告知临床 项目，临床见解将反馈到动物和实验室项目，以进一步 考核生物统计学核心的成员将为所有包含的研究项目提供援助 在这个项目中。核心C生物统计学的具体目标是： 1.为临床研究方案提供生物统计协作。这包括所有方面， 临床研究的设计、实施、分析和报告。 2.为实验室研究提供生物统计合作。这包括所有方面， 设计、进行、分析和报告此类研究，以及分析实验室结果， 结合项目5的临床研究或作为项目5的临床研究的结果。 3.为动物研究提供生物统计协作，包括设计和分析的所有方面 这样的研究。 4.协助监督数据管理、其他临床支持服务和跟踪 样本送交各项目进行分析，并将数据交回计算机进行统计分析。

The ultimate objective of the research projects in this application is to improve our understanding of mechanisms of disease in human myeloid leukemias, and to explore new therapeutic options relating to the disease pathways under investigation. It is anticipated that the laboratory and murine will inform the clinical project, and that the clinical insights will feed back to the animal and laboratory projects for further assessment. Members of the Biostatistics core will provide assistance to all the research projects contained in this program. The specific aims of Core C Biostatistics are: 1. To provide biostatistical collaboration for clinical research protocols. This includes all aspects of the design, conduct, analysis, and reporting of the clinical studies. 2. To provide biostatistical collaboration for the laboratory research studies. This includes all aspects of the design, conduct, analysis, and reporting of such studies, as well as the analysis of laboratory results in conjunction with, or as outcomes of, the clinical studies of Project 5. 3. To provide biostatistical collaboration for animal studies, including all aspects of the design and analysis of such studies. 4. To assist in the oversight of data management, other clinical support services, and the tracking of samples to Projects for analysis with data returned and computerized for statistical analysis.