Insectary for Scientific Training and Advances in Research (InSTAR)

项目摘要 – CORE D：昆虫科学培训和研究进展 (InSTAR) 昆虫提供了优秀的模型系统，可以用来研究宿主与其昆虫之间的相互作用 微生物群。这些昆虫模型促进了我们对微生物共生体对宿主影响的理解 发育、新陈代谢、免疫功能和整体系统适应性，并产生可概括的信息 告知人类健康。此外，昆虫的共生微生物对公众健康也有直接影响 因为微生物共生体影响昆虫的生存、发育、细胞功能和免疫力 病虫害媒介对全球公共卫生负担造成重大影响，特别是在 热带地区。该提案的中心目标是开发一个昆虫设施，以便能够利用 夏威夷大学马诺阿分校的研究人员利用昆虫来研究环境微生物组。目前， 这所主要研究型大学没有高密闭生物安全 2 级 (BSL-2) 设施，这极大地影响了 降低了该机构研究人员利用昆虫模型研究昆虫影响的能力 环境微生物组对人类健康的影响。拟议的科学培训和进步昆虫部 研究 (InSTAR) 将提供这样一个高封闭性、BSL-2 认证的昆虫空间，并极大地促进 使用昆虫模型来研究影响人类健康的生物医学问题。重要的是，InSTAR 设施将为该 COBRE 的至少四名初级调查员提供关键基础设施，并将充分 与 UHM 的现有设施集成，支持知名研究人员社区的研究 微生物组。从长远来看，该核心将促进夏威夷州的医学昆虫学，增加 应对昆虫造成的公共卫生威胁的能力。此外，还将推动相关研究 开发新的模型系统，重点关注独特的夏威夷本土昆虫，并作为一种资源 促进全球研究界了解夏威夷独特的生物多样性。

Project Summary – CORE D: Insectary for Scientific Training and Advances in Research (InSTAR) Insects provide excellent model systems with which to study the interactions between hosts and their microbiota. These insect models advance our understanding of the impact of microbial symbionts on host development, metabolism, immune function, and overall system fitness, and produce generalizable information that informs human health. In addition, the symbiotic microbes of insects have direct impacts on public health because microbial symbionts influence the survival, development, cellular function, and immunity of insect pests and disease vectors that contribute significantly to the global public health burden, especially in the tropics. The central objective of this proposal is to develop an insectary facility that will enable the use of insects to study the environmental microbiome by researchers at the University of Hawai`i at Mānoa. Currently, this major research university does not have a high-containment biosafety level 2 (BSL-2) facility, which greatly reduces the capacity of researchers at this institution to utilize insect models to study the impact of the environmental microbiome on human health. The proposed Insectary for Scientific Training and Advances in Research (InSTAR) will provide such a high-containment, BSL-2 certified insectary space and greatly facilitate use of insect models to investigate biomedical questions that impact human health. Importantly, the InSTAR facility will provide critical infrastructure for at least four junior investigators on this COBRE, and will fully integrate with existing facilities at UHM that support a renowned community of researchers investigating the microbiome. Over the long term, the core will facilitate medical entomology in the State of Hawai`i, increasing the capacity to respond to public health threats imposed by insects. In addition, it will promote research toward developing new model systems focusing on unique native Hawaiian insects, and serve as a resource that facilitates access to Hawaii`s distinctive biodiversity to the global research community.