Insectary for Scientific Training and Advances in Research (InSTAR)

项目摘要-核心D：科学培训和研究进展昆虫馆（InSTAR） 昆虫为研究寄主与寄主之间的相互作用提供了极好的模型系统。 微生物群这些昆虫模型推进了我们对微生物共生体对宿主影响的理解 发育、新陈代谢、免疫功能和整体系统健康，并产生可概括的信息 这对人类健康至关重要。此外，昆虫的共生微生物对公众健康也有直接影响 由于微生物共生体影响昆虫的生存、发育、细胞功能和免疫力， 对全球公共卫生负担有重大贡献的病虫害和病媒，特别是在 热带地区这项建议的中心目标是建立一个昆虫饲养设施， 昆虫研究环境微生物组的研究人员在夏威夷大学在马诺阿。目前， 这所主要的研究型大学没有高防护生物安全2级（BSL-2）设施，这极大地 降低了该机构研究人员利用昆虫模型研究 环境微生物对人类健康的影响建议的科学训练和进展昆虫 研究（InSTAR）将提供这样一个高遏制，BSL-2认证的昆虫空间，并大大促进 利用昆虫模型研究影响人类健康的生物医学问题。重要的是， 该设施将为COBRE上至少四名初级调查员提供关键基础设施，并将充分 与UHM现有的设施相结合，支持著名的研究人员社区， 微生物组从长远来看，该核心将促进夏威夷州的医学昆虫学， 应对昆虫造成的公共卫生威胁的能力。此外，它还将促进研究， 开发新的模式系统，专注于独特的本土夏威夷昆虫，并作为一种资源， 促进全球研究界获得夏威夷独特的生物多样性。

Project Summary – CORE D: Insectary for Scientific Training and Advances in Research (InSTAR) Insects provide excellent model systems with which to study the interactions between hosts and their microbiota. These insect models advance our understanding of the impact of microbial symbionts on host development, metabolism, immune function, and overall system fitness, and produce generalizable information that informs human health. In addition, the symbiotic microbes of insects have direct impacts on public health because microbial symbionts influence the survival, development, cellular function, and immunity of insect pests and disease vectors that contribute significantly to the global public health burden, especially in the tropics. The central objective of this proposal is to develop an insectary facility that will enable the use of insects to study the environmental microbiome by researchers at the University of Hawai`i at Mānoa. Currently, this major research university does not have a high-containment biosafety level 2 (BSL-2) facility, which greatly reduces the capacity of researchers at this institution to utilize insect models to study the impact of the environmental microbiome on human health. The proposed Insectary for Scientific Training and Advances in Research (InSTAR) will provide such a high-containment, BSL-2 certified insectary space and greatly facilitate use of insect models to investigate biomedical questions that impact human health. Importantly, the InSTAR facility will provide critical infrastructure for at least four junior investigators on this COBRE, and will fully integrate with existing facilities at UHM that support a renowned community of researchers investigating the microbiome. Over the long term, the core will facilitate medical entomology in the State of Hawai`i, increasing the capacity to respond to public health threats imposed by insects. In addition, it will promote research toward developing new model systems focusing on unique native Hawaiian insects, and serve as a resource that facilitates access to Hawaii`s distinctive biodiversity to the global research community.