ACTIVITY 4: BIOSTATISTICS AND COMPUTER CORE SUPPORT SERVICES

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项活动的总体目标是通过在生物统计分析、计算机建模、基于网络的数据输入、数据库开发和管理、数据存储、联网、高速连接、视频会议和培训，以在UHM生物科学研究人员的快速增长的骨干。 BDMF成立于2004年，由RCMI提供资金。在2006-2011年供资周期，生物统计基金的重点是全面服务生物统计核心的增长和发展，以及该基金未来制度化的规划。其具体目标是发展和增加生物统计学，数据管理和计算机建模方面的专业知识，以提供进行方法严格的生物医学研究所必需的定量资源。发展的领域包括：（1）一对一的咨询和统计分析研究人员的培训;（2）为基础和临床研究提供研究方法和研究设计方面的援助，包括撰写赠款援助;（3）计算功效和样本量要求;（4）数据收集、数据输入、数据管理以及数据工具和战略方面的培训; 5）用于分析MRI图像和相关临床和医学数据的多变量统计协议;和6）用于基因-环境相互作用和多维流行病学研究的计算机建模方法。 最初于1992年开始利用区域协调员基金开发的国家信息战略框架已获得部分机构资金，但区域协调员的持续支助使新兴信息技术的能力得以发展。在2006-2011年供资周期，国家科学基金的具体目标是满足生物科学研究人员在服务器工具、高速计算、网络和无线连接、台式机和笔记本电脑支持、视频会议和数据展示等领域不断变化的需求。开发领域包括：（1）数据管理和数据库服务;（2）网络和通信服务;（3）桌面和演示服务;（4）为研究人员和核心设施设计网页和开发网络工具。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this activity is to expand the capacity and enhance the expertise of the Biostatistics Data Management Facility (BDMF) and the Computer Network Support Facility (CNSF) by providing state-of-the-art, customized support services in biostatistical analysis, computer modeling, web-based data entry, database development and management, data storage, networking, high-speed connectivity, video conferencing and training to the fast-growing cadre of bioscience researchers at UHM. The BDMF was established in 2004 with RCMI funds. In the 2006-2011 funding cycle the BDMF is focused on the growth and development of a full-service biostatistics core as well as the planning for future institutionalization of the facility. The specific aim is to develop and increase available expertise in biostatistics, data management, and computer modeling in order to provide the quantitative resources essential for the conduct of methodologically rigorous biomedical research. Among the areas of development are 1) one-on-one consultation and training of investigators in statistical analysis; 2) assistance in research methodology and study design for both basic and clinical research studies, including grant-writing assistance; 3) calculation of power and sample-size requirements; 4) data collection, data entry, data management as well as training in data tools and strategies; 5) multivariate statistical protocols for analyses of MRI images and correlated clinical and medical data; and 6) computer modeling approaches for gene-environment interactions and multidimensional epidemiological studies. The CNSF, originally developed with RCMI funds beginning in 1992, has garnered partial institutional funding, but continued RCMI support has permitted the development of capacity in emerging information technologies. In the 2006-2011 funding cycle, the specific aim for the CNSF is to provide for the evolving needs of bioscience researchers in the areas of server-based tools, high-speed computation, network and wireless connectivity, desktop and laptop support, video-conferencing and data presentation. Among the areas of development are: 1) data management and database services; 2) network and communication services; 3) desktop and presentation services; and 4) web design and development of web-based tools for both researchers and core facilities.