ACTIVITY 4: BIOSTATISTICS AND COMPUTER CORE SUPPORT SERVICES

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 这项活动的总体目标是通过在生物统计分析、计算机建模、网上数据输入、数据库开发和管理、数据存储、联网、高速连接、视频会议和培训方面为生物统计数据管理设施(BDMF)和计算机网络支助设施(CNSF)提供最先进的、定制的支助服务，从而扩大生物统计数据管理设施(BDMF)和计算机网络支助设施(CNSF)的能力和提高其专门知识。 BDMF成立于2004年，由RCMI基金资助。在2006-2011年供资周期中，生物统计框架的重点是全面服务生物统计核心的成长和发展，以及该设施未来制度化的规划。其具体目的是发展和增加生物统计学、数据管理和计算机建模方面的现有专业知识，以便为进行方法学上严格的生物医学研究提供必要的量化资源。发展的领域包括：1)对研究人员进行统计分析方面的一对一咨询和培训；2)为基础研究和临床研究提供研究方法和研究设计方面的援助，包括拨款援助；3)计算能量和样本量要求；4)数据收集、数据输入、数据管理以及数据工具和策略培训；5)用于分析核磁共振图像和相关临床和医学数据的多元统计协议；以及6)用于基因-环境相互作用和多维流行病学研究的计算机模拟方法。 CNSF最初是从1992年开始用RCMI资金开发的，现在已经获得了部分机构资金，但RCMI的持续支持使新兴信息技术方面的能力得以发展。在2006-2011年供资周期内，国家科学基金的具体目标是满足生物科学研究人员在基于服务器的工具、高速计算、网络和无线连接、台式电脑和笔记本电脑支持、视频会议和数据展示等领域不断变化的需求。发展领域包括：1)数据管理和数据库服务；2)网络和通信服务；3)桌面和演示服务；4)为研究人员和核心设施设计和开发基于网络的工具。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The overall goal of this activity is to expand the capacity and enhance the expertise of the Biostatistics Data Management Facility (BDMF) and the Computer Network Support Facility (CNSF) by providing state-of-the-art, customized support services in biostatistical analysis, computer modeling, web-based data entry, database development and management, data storage, networking, high-speed connectivity, video conferencing and training to the fast-growing cadre of bioscience researchers at UHM. The BDMF was established in 2004 with RCMI funds. In the 2006-2011 funding cycle the BDMF is focused on the growth and development of a full-service biostatistics core as well as the planning for future institutionalization of the facility. The specific aim is to develop and increase available expertise in biostatistics, data management, and computer modeling in order to provide the quantitative resources essential for the conduct of methodologically rigorous biomedical research. Among the areas of development are 1) one-on-one consultation and training of investigators in statistical analysis; 2) assistance in research methodology and study design for both basic and clinical research studies, including grant-writing assistance; 3) calculation of power and sample-size requirements; 4) data collection, data entry, data management as well as training in data tools and strategies; 5) multivariate statistical protocols for analyses of MRI images and correlated clinical and medical data; and 6) computer modeling approaches for gene-environment interactions and multidimensional epidemiological studies. The CNSF, originally developed with RCMI funds beginning in 1992, has garnered partial institutional funding, but continued RCMI support has permitted the development of capacity in emerging information technologies. In the 2006-2011 funding cycle, the specific aim for the CNSF is to provide for the evolving needs of bioscience researchers in the areas of server-based tools, high-speed computation, network and wireless connectivity, desktop and laptop support, video-conferencing and data presentation. Among the areas of development are: 1) data management and database services; 2) network and communication services; 3) desktop and presentation services; and 4) web design and development of web-based tools for both researchers and core facilities.