Insectary for Scientific Training and Advances in Research (InSTAR) Core

昆虫科学培训和研究进展 (InSTAR) 核心

• 批准号: 10712775
• 负责人: PATRICIA A COUVILLON
• 金额: $ 16.67万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-15 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10712775
• 关键词: Address; Advocate; Affect; Agriculture; Arthropods; Award; Biodiversity; Biological; Biological Models; Biological Sciences; Biomedical Research; Blood; Breeding; Cell physiology; Centers of Research Excellence; Chikungunya virus; Collaborations; Collection; Communities; Containment; Core Facility; Culicidae; Dangerousness; Dengue Virus; Development; Disease Outbreaks; Disease Vectors; Drosophila genus; Drosophila melanogaster; Equipment; Fee-for-Service Plans; Food Webs; Food production; Funding; Generations; Goals; Grant; Hawaii; Hawaiian; Health; Health system; Home; Human; Human Microbiome; Immunity; Income; Infrastructure; Insect Vectors; Insecta; Institution; Institutionalization; Invertebrates; Laboratories; Link; Maintenance; Malaria; Mediating; Medical; Medical Entomology; Metabolism; Microbe; Modeling; Mosquito-borne infectious disease; Native Hawaiian; Pathway interactions; Phase; Procedures; Protocols documentation; Public Health; Recording of previous events; Research; Research Activity; Research Personnel; Research Support; Resources; Retirement; Role; Secure; Services; Structure; Study models; System; Taxus; Training; Universities; Vertebrates; West Nile virus; Work; Zika Virus; base; field study; fly; human pathogen; immune function; interest; medical schools; microbial; microbiome; microbiome research; microbiota; non-Native; pathogen; programs; sucking; symbiont; vector mosquito

PROJECT SUMMARY - Insectary for Scientific Training and Advances in Research (InSTAR) Invertebrates provide excellent model systems to study the interactions between hosts and their microbiota. These invertebrate models advance our understanding of the impact of microbial symbionts on host development, metabolism, immune function, and overall system health, and produce generalizable information that informs human health. In addition, the symbiotic microbes of invertebrates have direct impacts on public health as microbial symbionts influence the survival, development, cellular function, and immunity of pest species and disease vectors that contribute significantly to the global public health burden. The central objective of this proposal is to further develop a core facility that will enable the use of arthropods to study the environmental microbiome at the University of Hawai‘i at Mānoa. During Phase 1, the InSTAR established a unique collection of laboratory colonies for medically relevant mosquito vectors and Hawaiian Drosophila species, and established the only BSL-2/ACL-2 space to work with potentially dangerous insects in a laboratory setting in the state of Hawai‘i. The core also provided critical infrastructure for three former RPLs, and continues to support the independent research programs for two of those RPLs. During the next cycle of this CoBRE award, the InSTAR will i) provide infrastructure to support the research of two new Phase II RPLs, ii) establish a greater diversity of insect models in colony, with a special focus on Hawaiian Drosophila sp., iii) establish space to utilize for rearing only to allow a greater diversity of research activities in the non-rearing sections of the InSTAR core, and iv) coordinate with State, Federal, and academic groups to expand the InSTAR’s user base. Over the long term, the core will continue to facilitate medical entomology in the State of Hawai‘i, increasing the capacity to respond to public health threats imposed by invertebrates. In addition, it will promote research toward developing new model systems focusing on unique native Hawaiian invertebrate species, and serve as a resource that facilitates access to Hawaii‘s unique biodiversity to the global research community.

项目摘要-科学培训和研究进展昆虫馆（InSTAR） 无脊椎动物为研究宿主与其微生物群之间的相互作用提供了极好的模型系统。 这些无脊椎动物模型推进了我们对微生物共生体对宿主影响的理解 发育、新陈代谢、免疫功能和整体系统健康，并产生可概括的信息 这对人类健康至关重要。此外，无脊椎动物的共生微生物对公众健康也有直接影响。 健康作为微生物共生体影响害虫的生存、发育、细胞功能和免疫力 这些物种和病媒严重加重了全球公共卫生负担。中央 该提案的目的是进一步开发一个核心设施，使节肢动物能够用于研究 环境微生物组的研究。在第一阶段，InSTAR建立了一个 医学相关蚊子媒介和夏威夷果蝇的独特实验室菌落收集 物种，并建立了唯一的BSL-2/ACL-2空间与潜在的危险昆虫在一个 夏威夷州的一个实验室该核心还为三个前RPL提供了关键的基础设施， 并继续支持其中两个RPL的独立研究计划。在下一个周期中， 在此次授予的CoBRE合同中，InSTAR将i）提供基础设施，以支持两个新的第二阶段RPL的研究， ii）建立更多样化的群体昆虫模型，特别关注夏威夷果蝇，（三） 建立空间，利用饲养只允许在非饲养研究活动的更大的多样性 部分的InSTAR核心，以及iv）与国家，联邦和学术团体协调，以扩大 InSTAR的用户群。从长远来看，该核心将继续促进该州的医学昆虫学。 夏威夷，提高应对无脊椎动物造成的公共卫生威胁的能力。此外还将 促进研究，开发新的模式系统，重点是独特的本土夏威夷无脊椎动物 物种，并作为一种资源，有利于获得夏威夷独特的生物多样性的全球研究 社区