Kissing bug kill trap for control of Trypanosoma cruzi infection

用于控制克氏锥虫感染的接吻虫杀灭陷阱

• 批准号: 10493292
• 负责人: Michael Gilbert Banfield
• 金额: $ 16.75万
• 依托单位: TEXAS A&M AGRILIFE RESEARCH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-22 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10493292
• 关键词: Abate; Adult; Americas; Arthropods; Behavioral; Biological Assay; Biology; Blood donor screening; Chagas Disease; Data; Development; Disease; Ensure; Environment; Exposure to; Future; Guatemala; Habitats; Hemiptera; Human; Individual; Infection; Insect Vectors; Insecta; Insecticide Resistance; Intercept; Light; Maintenance; Manuals; Parasites; Pattern; Persons; Pharmaceutical Preparations; Pheromone; Population; Protocols documentation; Reduviidae; Research; Residual state; Risk; Risk Reduction; Sampling; Specimen; Standardization; Testing; Texas; Trypanosoma cruzi; Vaccines; Variant; citizen science; commercialization; cost effective; disorder control; disorder risk; expectation; experimental study; exposed human population; field study; improved; neglected tropical diseases; preservation; prevent; programs; prototype; spatiotemporal; tool; tool development; transmission process; vector; vector control; vector-borne

Project Summary Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, transmitted by triatomine ‘kissing bug’ insects. An estimated 6 million people are infected worldwide, including 240,000 to 350,000 people in the U.S., and WHO identifies Chagas disease as one of four Neglected Tropical Diseases that does not have a cost-effective control tool. Disease control relies heavily on reducing insect vectors although very few programs have allowed for sustainable solutions that prevent spill-over of kissing bugs from sylvatic habitats to re-colonize the domestic environment. This study will develop a kissing bug kill trap which autonomously captures, kills, and preserves the insect vectors of T. cruzi. Building on two years of field trials testing prior prototypes, this project will conduct behavioral bioassays with captive kissing bugs to identify LED light wavelengths with maximum attraction. We will also conduct two years of field experiments evaluating different LED light and reflective and fluorescing trap materials which will synergistically optimize the capture of kissing bugs while minimizing non-target bycatch. These field studies will be in Texas and Guatemala to ensure trap efficacy for multiple species of kissing bugs that are primary vectors in the Americas. The development of this standardized tool will allow for future large-scale surveillance to quantify spatio-temporal variation in kissing bugs. This tool that captures and kills dispersing adult kissing bugs will also permit future studies integrating this mass-trapping approach along with existing vector control tools to reduce human risk of exposure to T. cruzi.

项目摘要 查加斯病是由原生动物寄生虫锥虫克鲁兹引起的，由 三位生粒的“亲吻虫”昆虫。估计有600万人在全球受感染，包括 美国240,000至350,000人，并确定Chagas病为四种 没有具有成本效益的控制工具的被忽视的热带疾病。疾病控制 尽管很少有程序允许 可持续的解决方案可防止接吻虫子从sylvatic栖息地溢出以重新殖民 家庭环境。这项研究将发展一个接吻的虫子杀死陷阱，该陷阱自动 捕获，杀死和保留T. Cruzi的绝缘载体。建立在两年的现场试验的基础上 测试先前的原型，该项目将用圈养的亲吻虫进行行为生物测定 识别具有最大吸引力的LED光波长。我们还将进行两年 评估不同LED光以及反射性和荧光陷阱材料的现场实验 在最小化非目标的同时，它将协同优化接吻错误的捕获 旁观。这些现场研究将在德克萨斯州和危地马拉进行，以确保多个的陷阱效率 接吻虫子是美洲主要媒介的种类。这个发展 标准化工具将允许将来的大规模监视来量化时空 接吻虫子的变化。捕获和杀死分散成人亲吻虫的工具也将 允许未来的研究将这种大众捕获方法与现有矢量控制相结合 降低人类暴露于T. Cruzi的风险的工具。