Refinement of an Autocidal Gravid Ovitrap for mass-manufacturing

改进用于大规模生产的自杀妊娠产卵器

• 批准号: 8981549
• 负责人: Michael Gilbert Banfield
• 金额: $ 14.99万
• 依托单位: BANFIELDBIO INC.
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8981549
• 关键词: Address; Adhesives; Adult; Aedes; Affect; Arboviruses; Area; Biological Assay; Bite; Breeding; Centers for Disease Control and Prevention (U.S.); Chemicals; Communicable Diseases; Computer-Aided Design; Country; Culicidae; Dengue; Development; Devices; Disease; Disease Outbreaks; Dose; Drug Formulations; Ecosystem; Effectiveness; Engineering; Ensure; Environment; Epidemiology; Exclusion; Female; Flying body movement; Foundations; Funding; Future; Goals; Hand; Home environment; Industry; Infusion procedures; Injection of therapeutic agent; Insecta; Insecticides; Knowledge; Life; Longevity; Mission; Modification; Molds; Monitor; Mosquito Control; Output; Paper; Patient currently pregnant; Performance; Pesticides; Phase; Plastics; Population; Process; Production; Public Health; Puerto Rico; Quality Control; Quality of life; Regulation; Research; Risk; Running; Sentinel; Techniques; Technology; Testing; Time; Tropical Disease; United States National Institutes of Health; Validation; Vector-transmitted infectious disease; Virus Diseases; Water; Work; Yellow Fever; base; chikungunya; cost; cost effective; design; digital models; disorder control; egg; field study; improved; killings; model design; pesticide resistance; prevent; prototype; public health relevance; technology development; tool; vector; vector control; vector mosquito

 DESCRIPTION (provided by applicant): Lethal ovitraps are a modification of a common mosquito population monitoring technology: adult females are enticed to a water container to lay their eggs and are exposed to a lethal dose of pesticide. The Autocidal Gravid Ovitrap (AGO) improves this technology in several ways. It has been modified to make it more attractive to gravid Aedes aegypti. The killing agent is an adhesive, thus extending the useful field life while negating the need for insecticides. To-date, the AGO has been optimized using hand-made devices. Further development of the technology requires area-wide studies to determine epidemiological performance, and current manufacturing would be prohibitively expensive. Additionally, hand-crafting is not practical for quality control of a commercial product. This project aims to modify the current AGO design to make it suitable for mass production. The goal is to produce an efficacious, cost-effective, and durable AGO. Long-term objectives include optimizing use of the AGO for control of arbovirus-vectoring mosquitoes to prevent outbreaks of dengue and other diseases, and extending the technology for use with other container-breeding species of mosquitoes. The final result is expected to be a commercially viable product for professional and home use. Although an initial review suggests that the final product should be injection molded, other plastic-forming techniques may be used. Development of a mass-producible AGO will use an iterative process of design modeling, digital validation, prototyping, and testing against caged and/or wild mosquitoes. A team of academic mold engineering, plastic molding and insect trap design experts will collaborate in this process. Effectiveness of each design will be tested in competitive cage bioassays under field or semi-field conditions. Container-breeding mosquitoes such as Ae. aegypti and Ae. albopictus are day-biting nuisance mosquitoes. They are also vectors of serious viral diseases, including dengue fever, yellow fever, and chikungunya. Currently >2.5 billion people in tropical countries are at risk of infectio with dengue fever. The mission of the CDC-NCEZID is to detect, prevent, and control zoonotic infectious diseases. Dengue fever and chikungunya are not currently major threats to US residents, but these diseases are spreading as their mosquito vectors expand their ranges. The AGO will be both a monitoring tool to check the spread of these increasingly invasive species, and an effective control option for use in outbreaks by creating area-wide suppression of mosquito populations. It promises to be an important tool in the long term battle to control nuisance mosquitoes, improve quality of life for people in affected areas, and prevent vector-borne diseases.

 描述（由应用提供）：致命的卵子是对普通蚊子人口监测技术的修改：成年雌性被诱使饮水容器产卵，并暴露于致命的农药剂量。自动质膜卵形（AGO）以几种方式改进了这项技术。它已经进行了修改，以使其对Gratid Aedes Aegypti更具吸引力。杀戮剂是一种粘合剂，因此延长了有用的野生寿命，同时消除了对杀虫剂的需求。迄今为止，AGO已使用手工制作的设备进行了优化。该技术的进一步发展需要范围内的研究来确定流行病学的表现，并且当前的制造将被禁止昂贵。此外，手工制作对于商业产品的质量控制是不切实际的。该项目旨在修改当前的AGO设计，以使其适合大规模生产。目的是产生有效，成本效益且耐用的耐用性。长期目标包括优化AGO用于控制Arbovirus-Vectoring蚊子以防止爆发登革热和其他疾病的爆发，并将技术扩展到与其他集装箱繁殖物种一起使用的技术。尽管最初的审查表明最终产品应该是注射模制的，但可以使用其他塑料形成技术。质量可实现的AGO的开发将使用针对笼和/或野生蚊子的设计建模，数字验证，原型制作以及测试的迭代过程。一个学术霉菌工程，塑料成型和昆虫陷阱设计专家团队将在此过程中进行合作。每个设计的有效性将在竞争性的笼子生物测定中进行测试，在野外或半野外条件下。集装箱繁殖的蚊子，例如AE。埃及和ae。白化病是日间刺激性蚊子。它们也是严重病毒疾病的媒介，包括登革热，黄热病和基孔肯尼亚。目前，热带国家有25亿人有登革热感染的风险。 CDC-NCEZID的任务是检测，预防和控制人畜共患感染疾病。登革热和基孔肯雅亚目前并不是对美国居民的主要威胁，但是随着蚊子向量扩大范围，这些疾病正在蔓延。 AGO将是检查这些日益侵入性物种的传播的监测工具，也将是通过在范围内抑制蚊子种群的有效控制选择。它有望成为控制滋扰蚊子，改善受影响地区人们的生活质量并防止媒介传播疾病的长期战斗中的重要工具。