Refinement of an Autocidal Gravid Ovitrap for mass-manufacturing

改进用于大规模生产的自杀妊娠产卵器

• 批准号: 8981549
• 负责人: Michael Gilbert Banfield
• 金额: $ 14.99万
• 依托单位: BANFIELDBIO INC.
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8981549
• 关键词: Address; Adhesives; Adult; Aedes; Affect; Arboviruses; Area; Biological Assay; Bite; Breeding; Centers for Disease Control and Prevention (U.S.); Chemicals; Communicable Diseases; Computer-Aided Design; Country; Culicidae; Dengue; Development; Devices; Disease; Disease Outbreaks; Dose; Drug Formulations; Ecosystem; Effectiveness; Engineering; Ensure; Environment; Epidemiology; Exclusion; Female; Flying body movement; Foundations; Funding; Future; Goals; Hand; Home environment; Industry; Infusion procedures; Injection of therapeutic agent; Insecta; Insecticides; Knowledge; Life; Longevity; Mission; Modification; Molds; Monitor; Mosquito Control; Output; Paper; Patient currently pregnant; Performance; Pesticides; Phase; Plastics; Population; Process; Production; Public Health; Puerto Rico; Quality Control; Quality of life; Regulation; Research; Risk; Running; Sentinel; Techniques; Technology; Testing; Time; Tropical Disease; United States National Institutes of Health; Validation; Vector-transmitted infectious disease; Virus Diseases; Water; Work; Yellow Fever; base; chikungunya; cost; cost effective; design; digital models; disorder control; egg; field study; improved; killings; model design; pesticide resistance; prevent; prototype; public health relevance; technology development; tool; vector; vector control; vector mosquito

 DESCRIPTION (provided by applicant): Lethal ovitraps are a modification of a common mosquito population monitoring technology: adult females are enticed to a water container to lay their eggs and are exposed to a lethal dose of pesticide. The Autocidal Gravid Ovitrap (AGO) improves this technology in several ways. It has been modified to make it more attractive to gravid Aedes aegypti. The killing agent is an adhesive, thus extending the useful field life while negating the need for insecticides. To-date, the AGO has been optimized using hand-made devices. Further development of the technology requires area-wide studies to determine epidemiological performance, and current manufacturing would be prohibitively expensive. Additionally, hand-crafting is not practical for quality control of a commercial product. This project aims to modify the current AGO design to make it suitable for mass production. The goal is to produce an efficacious, cost-effective, and durable AGO. Long-term objectives include optimizing use of the AGO for control of arbovirus-vectoring mosquitoes to prevent outbreaks of dengue and other diseases, and extending the technology for use with other container-breeding species of mosquitoes. The final result is expected to be a commercially viable product for professional and home use. Although an initial review suggests that the final product should be injection molded, other plastic-forming techniques may be used. Development of a mass-producible AGO will use an iterative process of design modeling, digital validation, prototyping, and testing against caged and/or wild mosquitoes. A team of academic mold engineering, plastic molding and insect trap design experts will collaborate in this process. Effectiveness of each design will be tested in competitive cage bioassays under field or semi-field conditions. Container-breeding mosquitoes such as Ae. aegypti and Ae. albopictus are day-biting nuisance mosquitoes. They are also vectors of serious viral diseases, including dengue fever, yellow fever, and chikungunya. Currently >2.5 billion people in tropical countries are at risk of infectio with dengue fever. The mission of the CDC-NCEZID is to detect, prevent, and control zoonotic infectious diseases. Dengue fever and chikungunya are not currently major threats to US residents, but these diseases are spreading as their mosquito vectors expand their ranges. The AGO will be both a monitoring tool to check the spread of these increasingly invasive species, and an effective control option for use in outbreaks by creating area-wide suppression of mosquito populations. It promises to be an important tool in the long term battle to control nuisance mosquitoes, improve quality of life for people in affected areas, and prevent vector-borne diseases.

 描述（由申请人提供）：致命诱蚊产卵器是一种常见蚊子种群监测技术的改进：将成年雌性引诱到水容器中产卵，并暴露于致命剂量的杀虫剂。Autocidal Gravid Ovitrap（AGO）在几个方面改进了这项技术。它已被修改，使其更有吸引力的妊娠埃及伊蚊。杀灭剂是一种粘合剂，因此延长了田间使用寿命，同时无需杀虫剂。到目前为止，AGO已经使用手工制作的设备进行了优化。该技术的进一步发展需要在整个地区进行研究，以确定流行病学的表现，而目前的制造成本将高得令人望而却步。此外，手工制作对于商业产品的质量控制是不实际的。 该项目旨在修改当前的AGO设计，使其适合大规模生产。我们的目标是生产一种有效的，具有成本效益的，持久的AGO。长期目标包括优化AGO的使用，以控制携带虫媒病毒的蚊子，防止登革热和其他疾病的爆发，并将该技术推广用于其他容器繁殖的蚊子物种。最终的结果预计将是一个商业上可行的产品，供专业和家庭使用。虽然初步审查表明，最终产品应该是注塑成型，其他塑料成型技术可以使用。可大规模生产的AGO的开发将使用设计建模，数字验证，原型设计和针对笼中和/或野生蚊子的测试的迭代过程。一个由学术模具工程、塑料成型和昆虫诱捕器设计专家组成的团队将在这一过程中进行合作。将在田间或半田间条件下的竞争性笼生物测定中检测每种设计的有效性。 容器繁殖的蚊子，如Ae。埃及伊蚊和埃及伊蚊。白纹伊蚊是白天叮咬的讨厌蚊子。它们也是包括登革热、黄热病和基孔肯雅热在内的严重病毒性疾病的传播媒介。目前，热带国家有超过25亿人面临感染登革热的风险。CDC-NCEZID的使命是检测、预防和控制人畜共患传染病。登革热和基孔肯雅热目前还不是美国居民的主要威胁，但随着蚊子传播范围的扩大，这些疾病正在蔓延。AGO将既是一种监测工具，以检查这些日益增加的入侵物种的传播，也是一种有效的控制选择，通过在整个区域范围内抑制蚊子种群，用于疫情爆发。它有望成为长期控制讨厌的蚊子，改善受影响地区人民生活质量和预防病媒传播疾病的重要工具。