Kissing bug kill trap for control of Trypanosoma cruzi infection

用于控制克氏锥虫感染的接吻虫杀灭陷阱

• 批准号: 10354785
• 负责人: Michael Gilbert Banfield
• 金额: $ 23.02万
• 依托单位: TEXAS A&M AGRILIFE RESEARCH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-22 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10354785
• 关键词: Abate; Adult; Americas; Arthropods; Behavioral; Biological Assay; Biology; Blood donor screening; Chagas Disease; Data; Development; Disease; Ensure; Environment; Exposure to; Future; Guatemala; Habitats; Hemiptera; Human; Individual; Infection; Insect Vectors; Insecta; Insecticide Resistance; Intercept; Light; Maintenance; Manuals; Parasites; Pattern; Pharmaceutical Preparations; Pheromone; Population; Protocols documentation; Reduviidae; Research; Residual state; Risk; Risk Reduction; Sampling; Specimen; Standardization; Testing; Texas; Trypanosoma cruzi; Vaccines; Variant; citizen science; commercialization; cost effective; disorder control; disorder risk; expectation; experimental study; exposed human population; field study; improved; neglected tropical diseases; preservation; prevent; programs; prototype; spatiotemporal; tool; tool development; transmission process; vector; vector control; vector-borne

Project Summary Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, transmitted by triatomine ‘kissing bug’ insects. An estimated 6 million people are infected worldwide, including 240,000 to 350,000 people in the U.S., and WHO identifies Chagas disease as one of four Neglected Tropical Diseases that does not have a cost-effective control tool. Disease control relies heavily on reducing insect vectors although very few programs have allowed for sustainable solutions that prevent spill-over of kissing bugs from sylvatic habitats to re-colonize the domestic environment. This study will develop a kissing bug kill trap which autonomously captures, kills, and preserves the insect vectors of T. cruzi. Building on two years of field trials testing prior prototypes, this project will conduct behavioral bioassays with captive kissing bugs to identify LED light wavelengths with maximum attraction. We will also conduct two years of field experiments evaluating different LED light and reflective and fluorescing trap materials which will synergistically optimize the capture of kissing bugs while minimizing non-target bycatch. These field studies will be in Texas and Guatemala to ensure trap efficacy for multiple species of kissing bugs that are primary vectors in the Americas. The development of this standardized tool will allow for future large-scale surveillance to quantify spatio-temporal variation in kissing bugs. This tool that captures and kills dispersing adult kissing bugs will also permit future studies integrating this mass-trapping approach along with existing vector control tools to reduce human risk of exposure to T. cruzi.

项目摘要 查加斯病是由原生动物寄生虫克氏锥虫引起的，由 锥蝽“吻虫”昆虫。全球估计有600万人感染，其中包括 在美国有24万到35万人，世界卫生组织将恰加斯病确定为 被忽视的热带病，没有一个具有成本效益的控制工具。疾病控制 在很大程度上依赖于减少昆虫媒介，尽管很少有项目考虑到 可持续的解决方案，防止接吻虫从森林栖息地溢出，重新殖民 国内环境。本研究将开发一种能自动杀死接吻虫的诱捕器， 捕获、杀死和保存T.克鲁兹。基于两年的实地试验 测试之前的原型，这个项目将进行行为生物测定与圈养接吻错误 来识别具有最大吸引力的LED光波长。我们还将进行为期两年的 评估不同LED光以及反射和荧光陷阱材料的现场实验 这将协同优化捕捉接吻错误，同时最大限度地减少非目标 误捕这些实地研究将在德克萨斯州和危地马拉进行，以确保诱捕器对多种害虫的有效性。 一种接吻虫，是美洲的主要传播媒介。发展这个 标准化的工具将允许未来大规模的监测，以量化时空 接吻虫的变异这种捕捉和杀死分散的成年接吻虫的工具也将 允许将来的研究将这种大量诱捕方法与现有的病媒控制沿着 降低人类接触T的风险的工具。克鲁兹