Polymeric matrix loaded with tick repellent or toxic compositions for incorporation into fabrics or for granular dispersal

项目总结/摘要 在美国，蜱传播18种人类病原体，其中最严重的是莱姆病， 估计每年476，000例。目前的蜱虫管理和人类驱避剂和有毒产品， 在设计时，或者作为“事后考虑”， 蜱虫对这种病毒产生了越来越强的抵抗力目前消费者也在推动使用天然的 和有机害虫防治产品。随着全球气温的上升，导致蜱传疾病的发病率上升， 因此，迫切需要改进的蜱虫管理产品。第二阶段的应用将建立在 BanfieldBio开发了新型聚合物微粒作为非挥发性杀螨剂的载体， DWFP奖：“鼠类自动传播用于长期、区域性蜱虫控制”。基于鼓励 初步证据，我们建议，以适应聚合物微粒制造微孔 可配制成释放挥发性驱避剂和毒物的聚合物颗粒和纤维。制定 颗粒将用于景观处理，以杀死和击退蜱虫，纤维将被编织成 外套织物，以保护人类免受蜱虫感染和叮咬。候选活性成分为 诺卡酮和2-十一烷酮，其可以单独使用或彼此组合使用，和/或 氯菊酯该项目将针对两个物种，黑腿蜱和孤独的星星蜱，这两个都是 人类疾病的重要媒介，并将采用实验室和实地实验， 将这两种配方开发成新的原型产品。 拟议的研究和开发将最终导致五个潜在的成果：1）专有的 用一种或多种驱避剂和/或毒性化合物配制的聚合物微孔颗粒组合物， 2)证明所配制的颗粒组合物对未成熟和成年蜱有效，以及 准备扩大规模，测试和开发作为一个高级蜱预防治疗，3）织物 结合了用一种或多种驱避剂和/或有毒物质配制的专有聚合物微孔长丝， 4）证明用一种或多种驱避剂和/或有毒化合物配制的织物是 有效对抗未成熟和成年蜱，5）用一种或多种驱避剂和/或有毒物质配制的织物 用于制造绑腿的化合物，并准备将技术转移到商业织物生产中， 结合到多种类型的外衣服装中。 如适用，将提交专利申请，结果发表在同行评审的期刊上， 业务实施和商业化将被确定和利用。

Project Summary/Abstract Within the US, ticks transmit 18 human pathogens, one of the most serious being Lyme disease, with an estimated 476,000 cases per year. Current tick management and human repellent and toxic products were designed either with protection against ticks as an “after-thought” or through the use of a pyrethroid insecticide to which ticks are increasingly developing resistance. There is also a current push by consumers to use natural and organic pest control products. As global temperatures rise, leading to a higher incidence of tick-borne diseases, there is a critical need for improved tick management products. This Phase II application will build on the development of novel polymeric microparticles as carriers of non-volatile acaricides by BanfieldBio for the DWFP award on “Murine autodissemination for long-term, area-wide control of ticks”. Based on encouraging preliminary evidence, we propose to adapt the polymeric microparticles to manufacture microporous polymeric granules and fibers that can be formulated to release volatile repellents and toxicants. Formulated granules would be used in landscape treatments to kill and repel ticks, and the fibers would be woven into outerwear fabrics to protect humans from acquiring and being bitten by ticks. Candidate active ingredients are nootkatone and 2-undecanone, which could be used alone or in combination with each other and/or permethrin. The project will target two species, blacklegged ticks and lone star ticks, both of which are important vectors of human disease, and will employ laboratory and field experimentation to explore and develop both types of formulation into novel prototype products. The proposed research and development would culminate in five potential outcomes: 1) a proprietary polymeric microporous granular composition formulated with one or more repellent and/or toxic compounds, 2) a demonstration that the formulated granular composition is effective against immature and adult ticks, and ready for scale-up, testing and development as a landscape-level tick preventive treatment, 3) fabric incorporating proprietary polymeric microporous filaments formulated with one or more repellent and/or toxic compounds, 4) demonstration that the fabric formulated with one or more repellent and/or toxic compounds is effective against immature and adult ticks, 5) fabric formulated with one or more repellent and/or toxic compounds manufactured into gaiters, and ready for technology transfer to commercial fabric production and incorporation into multiple types of outerwear clothing. As applicable, patent applications will be filed, the results published in peer-reviewed journals, and pathways to operational implementation and commercialization will be identified and exploited.