Polymeric matrix loaded with tick repellent or toxic compositions for incorporation into fabrics or for granular dispersal

负载有驱蜱剂或有毒组合物的聚合物基质，用于掺入织物或用于颗粒分散

• 批准号: 10709538
• 负责人: Michael Gilbert Banfield
• 金额: $ 92.74万
• 依托单位: BANFIELDBIO INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-23 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10709538
• 关键词: Adult; Ambylomma americanum; Area; Award; Bacteria; Behavior; Biological Assay; Bite; Black-legged Tick; Characteristics; Chemicals; Clothing; Cytoplasmic Granules; Data; Detection; Development; Dose; Ensure; Evaluation; Fiber; Filament; Formulation; Geographic Locations; Goals; Habitats; Human; Incidence; Insecticides; Invaded; Journals; Laboratories; Legal patent; Longevity; Lyme Disease; Methods; Mus; Outcome; Paper; Participant; Pathway interactions; Peer Review; Permethrin; Persons; Pest Control; Phase; Poison; Polymers; Porosity; Preventive treatment; Procedures; Production; Publications; Publishing; Resistance; Resistance development; Route; Site; Solvents; Statistical Data Interpretation; Technology Transfer; Testing; Textiles; Tick Control; Tick-Borne Diseases; Ticks; Toxic effect; Volatilization; Walking; Work; Writing; acaricide; climate change; commercialization; controlled release; design; efficacy evaluation; experimental study; global temperature; human disease; human pathogen; improved; laboratory experiment; manufacture; manufacturing scale-up; manufacturing technology; meetings; novel; particle; preference; prevent; prototype; pyrethroid; research and development; scale up; tick bite; tick transmission; toxicant; vector

Project Summary/Abstract Within the US, ticks transmit 18 human pathogens, one of the most serious being Lyme disease, with an estimated 476,000 cases per year. Current tick management and human repellent and toxic products were designed either with protection against ticks as an “after-thought” or through the use of a pyrethroid insecticide to which ticks are increasingly developing resistance. There is also a current push by consumers to use natural and organic pest control products. As global temperatures rise, leading to a higher incidence of tick-borne diseases, there is a critical need for improved tick management products. This Phase II application will build on the development of novel polymeric microparticles as carriers of non-volatile acaricides by BanfieldBio for the DWFP award on “Murine autodissemination for long-term, area-wide control of ticks”. Based on encouraging preliminary evidence, we propose to adapt the polymeric microparticles to manufacture microporous polymeric granules and fibers that can be formulated to release volatile repellents and toxicants. Formulated granules would be used in landscape treatments to kill and repel ticks, and the fibers would be woven into outerwear fabrics to protect humans from acquiring and being bitten by ticks. Candidate active ingredients are nootkatone and 2-undecanone, which could be used alone or in combination with each other and/or permethrin. The project will target two species, blacklegged ticks and lone star ticks, both of which are important vectors of human disease, and will employ laboratory and field experimentation to explore and develop both types of formulation into novel prototype products. The proposed research and development would culminate in five potential outcomes: 1) a proprietary polymeric microporous granular composition formulated with one or more repellent and/or toxic compounds, 2) a demonstration that the formulated granular composition is effective against immature and adult ticks, and ready for scale-up, testing and development as a landscape-level tick preventive treatment, 3) fabric incorporating proprietary polymeric microporous filaments formulated with one or more repellent and/or toxic compounds, 4) demonstration that the fabric formulated with one or more repellent and/or toxic compounds is effective against immature and adult ticks, 5) fabric formulated with one or more repellent and/or toxic compounds manufactured into gaiters, and ready for technology transfer to commercial fabric production and incorporation into multiple types of outerwear clothing. As applicable, patent applications will be filed, the results published in peer-reviewed journals, and pathways to operational implementation and commercialization will be identified and exploited.

项目摘要/摘要 在美国，tick传输18种人类病原体，其中最严重的是莱姆病，有一个 估计每年476,000例。当前的壁虱管理以及人类复制品和有毒产品是 设计以防止tick的保护为“事后考虑”，或者通过使用拟除虫菊酯杀虫剂设计 壁虱越来越多地发展出抵抗力。消费者当前也有一种使用自然的推动 和有机害虫控制产品。随着全球温度的升高，导致tick传播的事件更高 疾病，需要改善tick管理产品的迫切需要。该第二阶段应用程序将基于 新型聚合微粒作为Banfieldbio的非易失性脂肪剂的载体的发展 DWFP授予“长期，区域范围内tick虫的鼠自动发电”奖。基于鼓励 初步证据，我们建议调整聚合微粒制造微孔 可以配制以释放挥发性复制物和有毒物质的聚合物颗粒和纤维。配制 颗粒将用于景观治疗中杀死和排斥壁虱，纤维将被编织成 外套的织物可保护人类免于被tick虫获取和咬伤。候选活性成分是 Nootkatone和2-甘油酮，可以单独使用或彼此组合和/或 苄氯菊酯。该项目将针对两种物种，黑腿tick和孤独的星形壁虱，这两个都是 人类疾病的重要载体，并将采用实验室和现场实验来探索和 将两种类型的配方开发为新型原型产品。 拟议的研发将达到五个潜在结果：1）专有 用一种或多种复制剂和/或有毒化合物配制的聚合微孔颗粒状组成， 2）表明配制的颗粒成分有效地侵害未成熟和成人壁虱，并且 准备进行扩大，测试和开发作为景观水平的预防治疗，3）面料 结合使用一个或多个复制剂和/或有毒的专有聚合物微孔细丝 化合物，4）证明用一种或多种复制剂和/或有毒化合物配制的织物是 有效防止未成熟和成人滴答，5）用一个或多个复制剂和/或有毒的织物制成的织物 制造的化合物，并准备将技术转移到商业织物生产和 掺入多种类型的外套服装中。 如有适用，将提交专利申请，在同行评审期刊和途径中发布的结果 将确定和利用运营实施和商业化。