16/24 Healthy Brain and Child Development National Consortium

项目摘要/摘要 神经发育过程是由基因和环境之间的动态相互作用塑造的。 生命早期的不良适应经历会改变发育轨迹，导致有害和持久的 发育后遗症。出生前和出生后的危险包括母体物质暴露、毒物暴露 怀孕和早期生活、母亲健康状况、父母精神病、虐待、结构性 种族主义和过度的压力。为了阐明各种环境危害是如何影响儿童发展的， 当务之急是建立一个关于生命最初10年的发展轨迹的标准模板 基于足够大且人口结构多样化的美国人口样本。要做到这一点， 健康大脑和儿童发展国家联盟(HBCD-NC)已经成立，以部署一个 协调、优化和创新的一套神经成像(MRI、EEG)措施，辅之以 广泛的行为、生理和心理工具，以及了解的生物标本 在美国24个地点登记的7500名母亲和婴儿的神经发育轨迹 州(美国)。HBCD-NC将在HBCD-NC的指导下执行共同研究协议 行政核心(HCAC)，并将汇集和分发一项全面和精心策划的研究 在HBCD-NC数据协调中心的指导下向整个科学界提供数据集 (HDCC)。HBCD-NC的总体目标是创建一个全面、协调和高质量的 将描述美国儿童典型神经发育轨迹的维度数据集 评估生物和环境暴露如何影响这些轨迹。我们将特别强调 了解出生前和出生后接触类阿片、大麻、酒精、烟草和/或其他物质的影响 物质。为了实现这些广泛的目标，参加调查的女性样本将包括：1)种族方面的， 代表美国人口的种族和社会经济多样性队列；2)孕妇 使用目标物质(类阿片、大麻、酒精、烟草)；3)人口统计和行为 类似的妇女在怀孕期间不使用物质，以进行有效的因果推断。此外，HBCD-NC 将确定关键的发展窗口，在此期间有害环境和保护环境都具有最大 对以后的神经发育结果的影响。大型、多模式、纵向和可概括的数据集 将首次由这项研究产生，将提供对儿童发展的新见解，使用国家- 最先进的方法。HBCD-NC研究将为改善儿童健康和发展的公共政策提供信息 全国各地的孩子们。

Project Summary/Abstract Neurodevelopmental processes are shaped by dynamic interactions between genes and environments. Maladaptive experiences early in life can alter developmental trajectories, leading to harmful and enduring developmental sequelae. Pre- and postnatal hazards include maternal substance exposure, toxicant exposures in pregnancy and early life, maternal health conditions, parental psychopathology, maltreatment, structural racism, and excessive stress. To elucidate how various environmental hazards impact child development, it is imperative that a normative template of developmental trajectories over the first 10 years of life be established based on a sufficiently large and demographically diverse sample of the US population. To accomplish this, the Healthy Brain and Child Development National Consortium (HBCD-NC) has been formed to deploy a harmonized, optimized, and innovative set of neuroimaging (MRI, EEG) measures complemented by an extensive battery of behavioral, physiological, and psychological tools, and biospecimens to understand neurodevelopmental trajectories in a sample of 7,500 mothers and infants enrolled at 24 sites across the United States (US). The HBCD-NC will carry out a common research protocol under direction of the HBCD-NC Administrative Core (HCAC) and will assemble and distribute a comprehensive and well-curated research dataset to the scientific community at large under the direction of the HBCD-NC Data Coordinating Center (HDCC). The overarching goal of the HBCD-NC is to create a comprehensive, harmonized, and high- dimensional dataset that will characterize typical neurodevelopmental trajectories in US children and that will assess how biological and environmental exposures affect those trajectories. A special emphasis will be placed on understanding the impact of pre- and postnatal exposure to opioids, marijuana, alcohol, tobacco and/or other substances. To address these broad objectives, the sample of women enrolled will include: 1) a racially, ethnically, and socioeconomically diverse cohort that is representative of the US population; 2) pregnant woman with use of targeted substances (opioids, marijuana, alcohol, tobacco); and 3) demographically and behaviorally similar women without substance use in pregnancy to enable valid causal inferences. In addition, the HBCD-NC will identify key developmental windows during which both harmful and protective environments have the most influence on later neurodevelopmental outcomes. The large, multi-modal, longitudinal, and generalizable dataset that will be produced for the first time by this study will provide novel insights into child development using state- of-the-art methods. The HBCD-NC study will inform public policy to improve the health and development of children across the nation.