16/24 Healthy Brain and Child Development National Consortium DIVERSITY SUPPLEMENT

摘要 孕妇使用药物是一个重大的公共卫生问题，可能导致 对后代有不良影响。健康大脑和儿童发展（HBCD） 父母补助金是：1） 检查行为，认知，生物，社会和情感方面 从出生前到10岁的儿童发展 （2）研究影响; 社会人口因素，压力和心理健康，遗传学， 产前物质暴露 关于儿童发展。但是，父项目的重点是数据收集和 婴儿期的发育阶段， 童年.这项工作将使用现有的数据， F.U.T.U.R.E.S.研究（“跟随城市青少年：每一步都是独特的和有弹性的， DA021059 ），研究了产前物质暴露对行为和 青春期的大脑发育在本拟议补充文件的目标1中，候选人将 检查PDE和照顾者心理健康对行为结果的相互作用， 青春期我们假设，PDE和护理人员心理健康状况不佳的组合 （特点： 抑郁、焦虑和/或压力的症状）会产生最糟糕的孩子。 结果。探索性分析将探讨效应是否随 物质或使用时间。在目标2中，候选人将检查PDE之间的相互作用 和照顾者心理健康对青少年大脑的影响 结构和功能。我们假设 PDE和护理人员心理健康状况不佳的组合将与大脑的变化相关， 体积和皮质厚度与单独有一个风险因素或没有风险的个体相比 因素这项工作将 更好地了解产妇的心理健康和照顾者 环境影响儿童发展的许多方面。作为一名全职研究员， 候选人没有机会 探索父母之外的研究兴趣 计划并接受训练， 有竞争力的未来研究生 最后， 这个培训项目将有助于加快候选人向研究生院的过渡 以及她的研究生涯轨迹

Abstract Substance use among pregnant women is a substantial public health concern that can result in adverse outcomes in offspring. The aims of the Healthy Brain and Child Development (HBCD) parent grant are to: 1) examine behavioral, cognitive, biological, social, and emotional aspects of child development from prenatal to 10 years old and 2) examine the impacts of sociodemographic factors, stress and mental health, genetics, and prenatal substance exposure on child development. However, the parent project is focused on data collection and on the developmental periods of infancy and childhood. The proposed work will use existing data from the F.U.T.U.R.E.S. study (“Following Urban Teens: Unique and Resilient at Every Step, DA021059 ), which examined the impact of prenatal substance exposure on behavioral and brain development in adolescence. In Aim 1 of this proposed supplement, the Candidate will examine interactions between PDE and caregiver mental health on behavioral outcomes in adolescence. We hypothesize that the combination of PDE and poor caregiver mental health (characterized by symptoms of depression, anxiety, and/or stress) will produce the worst child outcomes. Exploratory analyses will probe whether effects vary as a function of type of substance or duration of use. In Aim 2, the Candidate will examine interactions between PDE and caregiver mental health on adolescent brain structure and function. We hypothesize that the combination of PDE and poor caregiver mental health will be associated with variations in brain volume and cortical thickness compared to individuals with either one risk-factor alone or no risk factors. This work will provide a better understanding of maternal mental health and caregiver environment that influence many aspects of child development. As a full-time faculty researcher, the Candidate does not have the opportunity to explore research interests outside of the parent project and pursue training that would make her a competitive prospective graduate student. Ultimately, this training project will help accelerate the Candidate’s transition to graduate school and her research career trajectory.