Center for Biomedical OCT Research and Translation

生物医学OCT研究与转化中心

• 批准号: 10494619
• 负责人: Brett E Bouma
• 金额: $ 129.29万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-21 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10494619
• 关键词: 3-Dimensional; Address; Adoption; Algorithms; Angiography; Area; Artificial Intelligence; Biological; Biology; Biomedical Engineering; Biomedical Research; Birefringence; Blood flow; Caliber; Characteristics; Clinical; Clinical Research; Collaborations; Communication; Communities; Computer software; Data; Data Analyses; Dependence; Development; Diagnosis; Disease Progression; Drug Targeting; Educational workshop; Engineering; Formulation; Fostering; Functional Imaging; Funding; Gastrointestinal Endoscopy; Geographic Distribution; Goals; Hand; Head; Image; Imaging Device; Imaging technology; Individual; Instruction; Internet; Investigation; Lasers; Lead; Light; Machine Learning; Medical; Medical Imaging; Medicine; Methods; Microscope; Mission; Needles; Nerve; Neuroanatomy; Operative Surgical Procedures; Optical Coherence Tomography; Optics; Physics; Pilot Projects; Publications; Research; Research Personnel; Resolution; Resources; Retina; Retinal Diseases; Rewards; Rotation; Scientist; Services; Site; Source; Speed; System; Techniques; Technology; Tissue imaging; Tissues; Training; Training Programs; Translations; Vascular Diseases; Work; base; biological research; biomedical imaging; clinical diagnosis; clinical imaging; clinical research site; commercialization; contrast imaging; experience; experimental study; frontier; image guided; image processing; imaging platform; imaging system; improved; innovation; insight; instrument; instrumentation; light scattering; microscopic imaging; minimally invasive; neurosurgery; novel; novel therapeutic intervention; operation; polarimetry; post-doctoral training; pre-clinical; pre-clinical research; pre-doctoral; programs; recruit; response; signal processing; social media; symposium; technology research and development; tool

Project Summary Overall The Center for Biomedical OCT Research and Translation seeks to push the technological frontier of optical coherence tomography instrumentation and methods in response to challenges in biology and medicine. Fundamental to our approach, CBORT thrives on an intimate, push-pull relationship between physicists/engineers and biological, pre-clinical and clinical scientists. The most direct impact of the NCBIB will be to develop and provide broad access to powerful new tools for biological and clinical research. Facilitating rapid, high-resolution, high-contrast imaging through tailored, application-specific instruments will accelerate and open new avenues of biomedical research. Results of this effort may include, for example, the identification of new methods for diagnosis, new insights into disease or disease progression, or the formulation of new therapeutic strategies or drug targets. Further, the resulting biological and clinical research will identify new opportunities for commercialization of technology. By developing and making innovative and effective OCT technology available, we anticipate that there will be rapid progress and significant advances in each of these areas. Training and dissemination of OCT instruments and methods is another priority of CBORT. Regular symposia and workshops foster a broader communication within the field, provide access to results of research, and offer a hand-on experience with the construction, operation, and interpretation of data from state-of-the-art imaging systems. External users additionally have access to imaging systems within the Center to conduct focused experiments or to generate preliminary data. CBORT can also place imaging systems off-site for clinical or pre-clinical pilot studies. The Specific Aims of the TRD projects include the development of three-dimensional, high resolution retinal polarimetry and angiography, the development of a novel surgical guidance imaging system based on circular ranging OCT, and the development of polarimetry with optic axis mapping through narrow gauge needle probes. Our proposed research is significant to medicine in that it will provide new tools for the diagnosis of vascular and retinal diseases, new methods for precise, guided surgery, and a unique capability for quantitative polarimetry. Individual TRD projects contribute to the overall theme and goals of the program by pursuing the fundamental building blocks of OCT instrumentation, technology and methods. The TRD projects are highly synergistic in their cross-pollination of ideas and approaches and their mutual dependence on advances in fiberoptics, novel lasers, and unique signal and image processing techniques. Additionally, there is a strong component of artificial intelligence and machine learning underpinning each TRD.

项目摘要 总括 生物医学OCT研究和翻译中心寻求推动 光学相干层析成像仪器和方法应对生物学和生物科学领域的挑战 医药。作为我们方法的基础，CBORT的蓬勃发展依赖于 物理学家/工程师以及生物学、临床前和临床科学家。最直接的影响是 NCBIB将开发并提供广泛的途径，以获得强大的生物和临床新工具 研究。通过量身定做的、特定于应用的技术，实现快速、高分辨率、高对比度的成像 仪器将加速并开辟生物医学研究的新途径。这一努力的结果可能是 包括确定新的诊断方法、对疾病的新见解或 疾病进展，或制定新的治疗策略或药物靶点。此外， 由此产生的生物学和临床研究将确定新的商业化机会 技术通过开发和提供创新和有效的OCT技术，我们 预计在这些领域中的每一个领域都将取得快速进展和重大进展。 培训和传播OCT仪器和方法是CBORT的另一个优先事项。常规 座谈会和讲习班促进了实地更广泛的交流，提供了了解以下方面成果的途径 进行研究，并提供构建、操作和解释数据的实践经验 来自最先进的成像系统。外部用户还可以访问成像系统 在该中心内进行有针对性的实验或产生初步数据。CBORT还可以 将成像系统放置在异地，以进行临床或临床前试点研究。 TRD项目的具体目标包括开发三维、高分辨率 视网膜偏振和血管造影术--一种新型手术引导成像系统的开发 基于圆测距的OCT，以及通过光轴映射的偏振测量的发展 窄口径针状探头。 我们提出的研究对医学具有重要意义，因为它将为糖尿病的诊断提供新的工具 血管和视网膜疾病，精确、引导手术的新方法，以及独特的治疗能力 定量旋光法。 个别的研究与发展项目通过追求 OCT仪器、技术和方法的基本构件。铁路发展计划是 在思想和方法的交叉授粉以及相互依赖方面高度协同 光纤光学、新型激光器以及独特的信号和图像处理技术方面的进展。另外， 每一个TRD都有人工智能和机器学习的强大组成部分。