Center for Biomedical OCT Research and Translation

生物医学OCT研究与转化中心

基本信息

  • 批准号:
    8496780
  • 负责人:
  • 金额:
    $ 153.15万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-07-21 至 2016-06-30
  • 项目状态:
    已结题

项目摘要

Optical coherence tomography (OCT) has evolved into a powerful microscopy technique for a broad range of applications in biology and clinical medicine. It can safely be used to image biological tissue with high resolution and can easily integrate flexible, narrow diameter optical fiber probes for imaging internal organs. Recent advances have increased OCT imaging speeds by nearly two orders of magnitude, enabling microscopic, three-dimensional imaging over large fields-of-view, a capability that cannot be provided by conventional imaging or histology. Viewed across the entire range of biological and clinical applications, the opportunity presented by OCT technology is immense. State-of-the-art OCT technology, however, is not widely available to the biological and clinical communities. The few commercial systems that are available don't integrate recent advances and don't permit customization to new biomedical applications. Additionally, the technical complexity of OCT is a barrier to implementation and innovation outside of a limited number of technical academic research groups and these groups have been focused on a narrow sector of the potential applications in biology and medicine. The overriding motivation of this proposed Resource is to address the deficient accessibility of cutting-edge OCT instrumentation and technology. We propose to meet this need through the innovation of new technical capabilities that are motivated by significant biological and clinical challenges, and through translation, facilitated by direct collaboration. To launch the Resource, we have initiated six driving biomedical projects (DBPs) and through extensive discussions have jointly identified specific technical projects that will have significant biological and clinical impact. Projects that could serve more than one DBF or that represented a synergistic combination were identified to be particularly attractive for the initial efforts of the Resource. The selected projects naturally fall into three core thematic areas: advanced structural imaging, functional and compositional contrast, and hvbrid imaoino modalities.
光学相干层析成像(OCT)已经发展成为一种强大的显微技术,可用于广泛的 在生物学和临床医学中的应用。它可以安全地用于高密度生物组织的成像 该仪器具有高分辨率,可轻松集成用于成像内脏器官的灵活、窄直径光纤探头。 最近的进展使OCT成像速度提高了近两个数量级,使 在大视场范围内进行显微三维成像,这是 传统的成像或组织学。从生物和临床应用的整个范围来看, OCT技术带来的机遇是巨大的。 然而,最先进的OCT技术并没有广泛地应用于生物和临床社区。 少数几个可用的商业系统没有集成最新的进展,也不允许 针对新的生物医学应用进行定制。此外,OCT的技术复杂性是实现 在有限数量的技术学术研究小组之外实施和创新 研究小组一直专注于生物和医学领域潜在应用中的一小部分。这个 此推荐资源的首要动机是解决前沿OCT的可访问性不足问题 仪器和技术。我们建议通过创新新技术来满足这一需求 由重大的生物和临床挑战以及通过翻译而激发的能力, 由直接协作推动。 为了启动资源,我们发起了六个推动生物医学项目(DBP),并通过广泛的 讨论共同确定了将具有重大生物学和临床意义的具体技术项目 冲击力。可以服务于多个DBF或代表协同组合的项目有 被确定为对资源的初始努力特别有吸引力。选定的项目自然会落在 分为三个核心主题领域:先进的结构成像、功能和成分对比以及 Hvbrid Imao ino模式。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Brett E Bouma其他文献

Technology Insight: optical coherence tomography—current status and future development
技术洞察:光学相干断层扫描——现状与未来发展
  • DOI:
    10.1038/ncpcardio0482
  • 发表时间:
    2006-03-01
  • 期刊:
  • 影响因子:
    44.200
  • 作者:
    Adrian F Low;Guillermo J Tearney;Brett E Bouma;Ik-Kyung Jang
  • 通讯作者:
    Ik-Kyung Jang

Brett E Bouma的其他文献

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{{ truncateString('Brett E Bouma', 18)}}的其他基金

Dual-modality FLIm and PSOCT for intravascular imaging of plaque in patients
双模态 FLIm 和 PSOCT 用于患者斑块血管内成像
  • 批准号:
    10677774
  • 财政年份:
    2021
  • 资助金额:
    $ 153.15万
  • 项目类别:
Dual-modality FLIm and PSOCT for intravascular imaging of plaque in patients
双模态 FLIm 和 PSOCT 用于患者斑块血管内成像
  • 批准号:
    10306091
  • 财政年份:
    2021
  • 资助金额:
    $ 153.15万
  • 项目类别:
Center for Biomedical OCT Research and Translation
生物医学OCT研究与转化中心
  • 批准号:
    9521706
  • 财政年份:
    2017
  • 资助金额:
    $ 153.15万
  • 项目类别:
Intracoronary imaging of plaque collagen in patients
患者斑块胶原的冠状动脉内成像
  • 批准号:
    8735353
  • 财政年份:
    2014
  • 资助金额:
    $ 153.15万
  • 项目类别:
Intracoronary imaging of plaque collagen in patients
患者斑块胶原的冠状动脉内成像
  • 批准号:
    9263997
  • 财政年份:
    2014
  • 资助金额:
    $ 153.15万
  • 项目类别:
Intracoronary imaging of plaque collagen in patients
患者斑块胶原的冠状动脉内成像
  • 批准号:
    8842192
  • 财政年份:
    2014
  • 资助金额:
    $ 153.15万
  • 项目类别:
Increasing the diagnostic yield of low-risk bronchial biopsy in the evaluation of
提高低风险支气管活检评估的诊断率
  • 批准号:
    8531402
  • 财政年份:
    2013
  • 资助金额:
    $ 153.15万
  • 项目类别:
Increasing the diagnostic yield of low-risk bronchial biopsy in the evaluation of
提高低风险支气管活检评估的诊断率
  • 批准号:
    8654306
  • 财政年份:
    2013
  • 资助金额:
    $ 153.15万
  • 项目类别:
Center for Biomedical OCT Research and Translation
生物医学OCT研究与转化中心
  • 批准号:
    10494619
  • 财政年份:
    2011
  • 资助金额:
    $ 153.15万
  • 项目类别:
Center for Biomedical OCT Research and Translation
生物医学OCT研究与转化中心
  • 批准号:
    8078519
  • 财政年份:
    2011
  • 资助金额:
    $ 153.15万
  • 项目类别:

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