Center for Biomedical OCT Research and Translation

光学相干断层扫描 (OCT) 已发展成为一种强大的显微技术，可用于广泛的研究 在生物学和临床医学中的应用。它可以安全地用于对生物组织进行高成像 分辨率，并且可以轻松集成灵活的窄直径光纤探头以对内脏器官进行成像。 最近的进展将 OCT 成像速度提高了近两个数量级，使得 大视场的微观三维成像，这是目前无法提供的能力 常规成像或组织学。从整个生物和临床应用范围来看， OCT 技术带来的机遇是巨大的。 然而，最先进的 OCT 技术尚未广泛应用于生物和临床界。 少数可用的商业系统没有集成最新的进步，也不允许 定制新的生物医学应用。此外，OCT 的技术复杂性也是其实现的一个障碍。 在有限数量的技术学术研究小组之外实施和创新 小组一直专注于生物学和医学潜在应用的一个狭窄领域。的 该资源的首要动机是解决尖端 OCT 的可访问性不足的问题 仪器仪表和技术。我们建议通过新技术的创新来满足这一需求 由重大生物学和临床挑战激发的能力，并通过翻译， 通过直接合作促进。 为了启动该资源，我们启动了六个驱动生物医学项目 (DBP)，并通过广泛的 讨论共同确定了具有重大生物学和临床意义的具体技术项目 影响。可以服务多个 DBF 或代表协同组合的项目是 被认为对该资源的初步努力特别有吸引力。选定的项目自然落下 分为三个核心主题领域：高级结构成像、功能和成分对比以及 混合动力imaoino模式。

Optical coherence tomography (OCT) has evolved into a powerful microscopy technique for a broad range of applications in biology and clinical medicine. It can safely be used to image biological tissue with high resolution and can easily integrate flexible, narrow diameter optical fiber probes for imaging internal organs. Recent advances have increased OCT imaging speeds by nearly two orders of magnitude, enabling microscopic, three-dimensional imaging over large fields-of-view, a capability that cannot be provided by conventional imaging or histology. Viewed across the entire range of biological and clinical applications, the opportunity presented by OCT technology is immense. State-of-the-art OCT technology, however, is not widely available to the biological and clinical communities. The few commercial systems that are available don't integrate recent advances and don't permit customization to new biomedical applications. Additionally, the technical complexity of OCT is a barrier to implementation and innovation outside of a limited number of technical academic research groups and these groups have been focused on a narrow sector of the potential applications in biology and medicine. The overriding motivation of this proposed Resource is to address the deficient accessibility of cutting-edge OCT instrumentation and technology. We propose to meet this need through the innovation of new technical capabilities that are motivated by significant biological and clinical challenges, and through translation, facilitated by direct collaboration. To launch the Resource, we have initiated six driving biomedical projects (DBPs) and through extensive discussions have jointly identified specific technical projects that will have significant biological and clinical impact. Projects that could serve more than one DBF or that represented a synergistic combination were identified to be particularly attractive for the initial efforts of the Resource. The selected projects naturally fall into three core thematic areas: advanced structural imaging, functional and compositional contrast, and hvbrid imaoino modalities.