Center for Biomedical OCT Research and Translation

 描述(由申请者提供)：总的来说，生物医学OCT研究和翻译中心致力于推动光学相干断层扫描仪器和方法的技术前沿，以应对生物学和医学方面的挑战。作为我们方法的基础，CBORT依靠物理学家/工程师与生物学、临床前和临床科学家之间的亲密推拉关系而蓬勃发展。该资源最直接的影响将是为生物和临床研究开发和提供广泛的强大的新工具。通过量身定制的 特定用途的仪器将加速并开辟生物医学研究的新途径。这一努力的结果可能包括，例如，确定新的诊断方法，对疾病或疾病进展的新见解，或制定新的治疗策略或药物靶点。此外，我们预计由此产生的一些生物学和临床研究将确定技术商业化的新机会。通过开发和提供创新和有效的OCT技术，我们预计在这些领域中的每个领域都将取得快速进展和重大进展。培训和传播OCT仪器和方法是CBORT的另一个优先事项。定期的研讨会和研讨会促进了领域内更广泛的交流，提供了访问研究结果的途径，并提供了从最先进的成像系统构建、操作和解释数据的实践经验。外部用户还可以访问资源内的成像系统，以进行有针对性的实验或生成初步数据。CBORT还可以将成像系统放置在非现场，以进行临床或临床前试点研究。

 DESCRIPTION (provided by applicant): Overall the Center for Biomedical OCT Research and Translation seeks to push the technological frontier of optical coherence tomography instrumentation and methods in response to challenges in biology and medicine. Fundamental to our approach, CBORT thrives on an intimate, push-pull relationship between physicists/engineers and biological, pre-clinical and clinical scientists. The most direct impact o the Resource will be to develop and provide broad access to powerful new tools for biological and clinical research. Facilitating rapid, high-resolution, high-contrast imaging through tailored, application-specific instruments will accelerate and open new avenues of biomedical research. Results of this effort may include, for example, the identification of new methods for diagnosis, new insights into disease or disease progression, or the formulation of new therapeutic strategies or drug targets. Further, we anticipate that some of the resulting biological and clinicl research will identify new opportunities for commercialization of technology. By developing and making innovative and effective OCT technology available, we anticipate that there will be rapid progress and significant advances in each of these areas. Training and dissemination of OCT instruments and methods is another priority of CBORT. Regular symposia and workshops foster a broader communication within the field, provide access to results of research, and offer a hand-on experience with the construction, operation, and interpretation of data from state-of-the-art imaging systems. External users additionally have access to imaging systems within the Resource to conduct focused experiments or to generate preliminary data. CBORT can also place imaging systems off-site for clinical or pre-clinical pilot studies.