Center for Biomedical OCT Research and Translation

生物医学OCT研究与转化中心

• 批准号: 9073547
• 负责人: Brett E Bouma
• 金额: $ 146.03万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-21 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9073547
• 关键词: Acoustics; Address; Adoption; Algorithms; Angiography; Animal Disease Models; Area; Biological; Biology; Biomechanics; Biomedical Research; Biomedical Technology; Blood capillaries; Blood flow; Caliber; Characteristics; Clinical; Clinical Research; Collaborations; Communication; Communities; Complex; Computer software; Computers and Advanced Instrumentation; Cornea; Cystic Fibrosis; Data; Data Analyses; Diagnosis; Diagnostic; Disease; Disease Progression; Drug Targeting; Early Diagnosis; Educational workshop; Engineering; Ferrets; Fiber Optics; Formulation; Fostering; Functional Imaging; Funding; Gastrointestinal Endoscopy; Geographic Distribution; Goals; Hand; Housing; Image; Imagery; Imaging Device; Imaging technology; Individual; Inflammation; Instruction; Internet; Investigation; Knowledge; Lead; Life; Lymphatic; Maps; Measures; Medical; Medical Imaging; Medicine; Methods; Microscope; Mission; Modeling; Mucociliary Clearance; Mus; Optical Coherence Tomography; Optics; Organ; Peripheral Nerves; Pilot Projects; Plague; Property; Publications; Recruitment Activity; Research; Research Personnel; Resolution; Resources; Respiratory physiology; Rewards; Scanning; Scientist; Services; Shapes; Site; Speed; Stress; Technology; Tissue imaging; Tissues; Training; Training Programs; Translational Research; Translations; Work; base; biological research; capillary; clinical Diagnosis; clinical research site; commercialization; contrast imaging; design; elastography; experience; flexibility; frontier; image processing; imaging system; improved; in vivo imaging; innovation; insight; instrument; instrumentation; interstitial; microscopic imaging; novel therapeutic intervention; operation; post-doctoral training; pre-clinical; pre-doctoral; public health relevance; research and development; research study; response; sound; symposium; tool; vibration; viscoelasticity

 DESCRIPTION (provided by applicant): Overall the Center for Biomedical OCT Research and Translation seeks to push the technological frontier of optical coherence tomography instrumentation and methods in response to challenges in biology and medicine. Fundamental to our approach, CBORT thrives on an intimate, push-pull relationship between physicists/engineers and biological, pre-clinical and clinical scientists. The most direct impact o the Resource will be to develop and provide broad access to powerful new tools for biological and clinical research. Facilitating rapid, high-resolution, high-contrast imaging through tailored, application-specific instruments will accelerate and open new avenues of biomedical research. Results of this effort may include, for example, the identification of new methods for diagnosis, new insights into disease or disease progression, or the formulation of new therapeutic strategies or drug targets. Further, we anticipate that some of the resulting biological and clinicl research will identify new opportunities for commercialization of technology. By developing and making innovative and effective OCT technology available, we anticipate that there will be rapid progress and significant advances in each of these areas. Training and dissemination of OCT instruments and methods is another priority of CBORT. Regular symposia and workshops foster a broader communication within the field, provide access to results of research, and offer a hand-on experience with the construction, operation, and interpretation of data from state-of-the-art imaging systems. External users additionally have access to imaging systems within the Resource to conduct focused experiments or to generate preliminary data. CBORT can also place imaging systems off-site for clinical or pre-clinical pilot studies.

 描述（由申请人提供）：总体而言，生物医学 OCT 研究和翻译中心致力于推动光学相干断层扫描仪器和方法的技术前沿，以应对生物学和医学领域的挑战。作为我们方法的基础，CBORT 的蓬勃发展依赖于物理学家/工程师与生物学、临床前和临床科学家之间的密切、推拉关系。该资源最直接的影响将是为生物和临床研究开发强大的新工具并提供广泛的获取途径。通过定制、促进快速、高分辨率、高对比度成像 专用仪器将加速并开辟生物医学研究的新途径。这项努力的结果可能包括，例如，确定新的诊断方法、对疾病或疾病进展的新见解、或制定新的治疗策略或药物靶点。此外，我们预计由此产生的一些生物和临床研究将发现技术商业化的新机会。通过开发和提供创新且有效的 OCT 技术，我们预计这些领域都会取得快速进展和重大进展。 OCT 仪器和方法的培训和传播是 CBORT 的另一个优先事项。定期举办的研讨会和研讨会促进了该领域内更广泛的交流，提供研究成果的获取，并提供构建、操作和解释来自最先进成像系统的数据的实践经验。外部用户还可以访问资源内的成像系统来进行重点实验或生成初步数据。 CBORT 还可以将成像系统放置在异地进行临床或临床前试点研究。