Center for Biomedical OCT Research and Translation

 描述（由申请人提供）：总体而言，生物医学OCT研究和翻译中心旨在推动光学相干断层扫描仪器和方法的技术前沿，以应对生物学和医学方面的挑战。我们的方法的基础，CBORT蓬勃发展的物理学家/工程师和生物，临床前和临床科学家之间的亲密，推拉关系。该资源最直接的影响将是为生物和临床研究开发和提供广泛的强大新工具。通过量身定制的， 专用仪器将加速生物医学研究并开辟新的途径。这一努力的结果可能包括，例如，确定新的诊断方法，对疾病或疾病进展的新见解，或制定新的治疗策略或药物靶点。此外，我们预计，一些由此产生的生物和临床研究将确定技术商业化的新机会。通过开发和提供创新和有效的OCT技术，我们预计这些领域将取得快速进展和重大进步。OCT仪器和方法的培训和传播是CBORT的另一个优先事项。定期举办的研讨会和讲习班促进了该领域内更广泛的交流，提供了对研究成果的访问，并提供了对来自最先进成像系统的数据的构建，操作和解释的实践经验。外部用户还可以访问资源内的成像系统，以进行重点实验或生成初步数据。CBORT还可以将成像系统放置在临床或临床前试点研究的场外。

 DESCRIPTION (provided by applicant): Overall the Center for Biomedical OCT Research and Translation seeks to push the technological frontier of optical coherence tomography instrumentation and methods in response to challenges in biology and medicine. Fundamental to our approach, CBORT thrives on an intimate, push-pull relationship between physicists/engineers and biological, pre-clinical and clinical scientists. The most direct impact o the Resource will be to develop and provide broad access to powerful new tools for biological and clinical research. Facilitating rapid, high-resolution, high-contrast imaging through tailored, application-specific instruments will accelerate and open new avenues of biomedical research. Results of this effort may include, for example, the identification of new methods for diagnosis, new insights into disease or disease progression, or the formulation of new therapeutic strategies or drug targets. Further, we anticipate that some of the resulting biological and clinicl research will identify new opportunities for commercialization of technology. By developing and making innovative and effective OCT technology available, we anticipate that there will be rapid progress and significant advances in each of these areas. Training and dissemination of OCT instruments and methods is another priority of CBORT. Regular symposia and workshops foster a broader communication within the field, provide access to results of research, and offer a hand-on experience with the construction, operation, and interpretation of data from state-of-the-art imaging systems. External users additionally have access to imaging systems within the Resource to conduct focused experiments or to generate preliminary data. CBORT can also place imaging systems off-site for clinical or pre-clinical pilot studies.