Center for Biomedical OCT Research and Translation

生物医学OCT研究与转化中心

• 批准号: 8305476
• 负责人: Brett E Bouma
• 金额: $ 124.05万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-21 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8305476
• 关键词: Address; Adoption; Area; Automobile Driving; Biological; Biology; Biomedical Research; Boston; Caliber; Catheters; Clinical; Clinical Medicine; Clinical Research; Collaborations; Communities; Complement; Development; Diagnosis; Disease; Disease Progression; Drug Delivery Systems; Drug Formulations; Elements; Functional Imaging; Goals; Histology; Image; Imaging Device; Instruction; Interdisciplinary Study; Lead; Light; Medicine; Methods; Microscopic; Microscopy; Modality; Motivation; Needles; Optical Coherence Tomography; Organ; Regulatory Pathway; Research; Research Personnel; Resolution; Resources; Sampling; Services; Site; Solutions; Speed; Structure; System; Techniques; Technology; Three-Dimensional Imaging; Tissues; Training; Training Activity; Translational Research; Translations; Validation; Work; biological research; clinical application; commercialization; design; experience; falls; flexibility; imaging probe; innovation; insight; instrument; instrumentation; medical schools; meetings; millimeter; new technology; novel; novel therapeutics; optical fiber; pre-clinical; programs; research and development; response; skills

Optical coherence tomography (OCT) has evolved into a powerful microscopy technique for a broad range of applications in biology and clinical medicine. It can safely be used to image biological tissue with high resolution and can easily integrate flexible, narrow diameter optical fiber probes for imaging internal organs. Recent advances have increased OCT imaging speeds by nearly two orders of magnitude, enabling microscopic, three-dimensional imaging over large fields-of-view, a capability that cannot be provided by conventional imaging or histology. Viewed across the entire range of biological and clinical applications, the opportunity presented by OCT technology is immense. State-of-the-art OCT technology, however, is not widely available to the biological and clinical communities. The few commercial systems that are available don't integrate recent advances and don't permit customization to new biomedical applications. Additionally, the technical complexity of OCT is a barrier to implementation and innovation outside of a limited number of technical academic research groups and these groups have been focused on a narrow sector of the potential applications in biology and medicine. The overriding motivation of this proposed Resource is to address the deficient accessibility of cutting-edge OCT instrumentation and technology. We propose to meet this need through the innovation of new technical capabilities that are motivated by significant biological and clinical challenges, and through translation, facilitated by direct collaboration. To launch the Resource, we have initiated six driving biomedical projects (DBPs) and through extensive discussions have jointly identified specific technical projects that will have significant biological and clinical impact. Projects that could serve more than one DBF or that represented a synergistic combination were identified to be particularly attractive for the initial efforts of the Resource. The selected projects naturally fall into three core thematic areas: advanced structural imaging, functional and compositional contrast, and hvbrid imaoino modalities.

光学相干断层扫描（OCT）已经发展成为一种强大的显微镜技术，用于广泛的成像领域。 应用于生物学和临床医学。它可以安全地用于对生物组织进行成像， 它可以轻松集成灵活的窄直径光纤探头，用于内部器官成像。 最近的进展使OCT成像速度提高了近两个数量级， 显微镜，三维成像在大视场，一个能力，不能提供的 常规成像或组织学。从生物学和临床应用的整个范围来看， OCT技术带来的机会是巨大的。 然而，最先进的OCT技术尚未广泛应用于生物和临床领域。 现有的几个商业系统没有集成最新的进步， 定制新的生物医学应用。此外，OCT的技术复杂性是实现的障碍。 在数量有限的技术学术研究小组之外进行实施和创新， 研究小组一直专注于生物学和医学中潜在应用的一个狭窄领域。的 该拟议资源的首要动机是解决尖端OCT的可访问性不足的问题 仪器和技术。我们建议通过新技术的创新来满足这一需求。 由重大生物学和临床挑战激发的能力，并通过翻译， 通过直接合作。 为了启动资源，我们启动了六个推动生物医学项目（DBP），并通过广泛的 讨论共同确定了具体的技术项目，将有重大的生物和临床意义， 冲击可为多于一个设计、建造及营运基金提供服务，或可发挥协同效益的项目， 被认为对资源的初步努力特别有吸引力。入选项目自然落在 分为三个核心主题领域：先进的结构成像，功能和成分对比， hvbrid imaoino模式。