Alterations and Renovations

新英格兰北部临床和翻译研究网络(NNE-CTR)由 MaineHealth缅因州医学中心研究所(MMCRI)、佛蒙特州大学(UVM)和 南缅因州大学(USM)这些机构在翻译研究方面有着良好的记录 以及医疗保健领域的创新。转化研究成功的关键是临床前研究的可用性 动物模型，以确定疾病机制，并在移动之前测试药物或其他治疗方法 送进诊所。MMCRI拥有强大的小鼠基因组修改资源，已开发出小鼠模型 疾病已有15年之久，并一直处于使用CRISPR-Cas进行小鼠基因组修改的前沿 技术。该资源由美国实验动物认证协会提供支持 CARE认证的最先进的动物设施，饲养老鼠和老鼠。NNE-CTR在一定程度上支持 MMCRI上的小鼠基因组修改资源，所有NNE-CTR成员以及 非成员，科布雷支持调查人员和地区调查人员。对汽车的高需求 由NNE-CTR成员和其他地区建立复杂的人类疾病小鼠模型 翻译研究人员，结合MMCRI的新教师招聘和更多的动物使用 现有教员的模型，导致需要在我们的屏障动物中扩大动物住房空间 MMCRI的设施。拟议的翻修将把一个储藏室改造成一个额外的鼠标外壳 房间，并将动物设施附近的空间改建为储藏区。翻新创造新的 老鼠房将需要对暖通空调系统进行广泛的更改，并移动门以带来新的 动物设施围栏部分内的动物室。扩建工程将容纳新的 为NNE-CTR成员以及该地区其他翻译研究人员开发的小鼠模型。通过 扩大鼠舍设施，包括新鼠模型的生成和实验方案 研究这些新的鼠标模型将会更快和更具成本效益。

The Northern New England Clinical and Translational Research Network (NNE-CTR) is comprised of the MaineHealth Maine Medical Center Research Institute (MMCRI), the University of Vermont (UVM) and the University of Southern Maine (USM). These institutions have a strong track record of translational research and innovation in healthcare. Critical to the success of translational research is the availability of preclinical animal models to identify disease mechanisms, and test drugs or other therapeutic approaches before moving into the clinic. MMCRI has a strong mouse genome modification resource that has developed mouse models of disease for over 15 years, and has been at the forefront of mouse genome modification using CRISPR-Cas technologies. This resource is supported by an American Association for Accreditation of Laboratory Animal Care accredited, state-of-the-art animal facility that houses mice and rats. The NNE-CTR supports, in part, the Mouse Genome Modification Resource at MMCRI, which is accessible to all NNE-CTR members, as well as non-members, COBRE supported investigators, and regional investigators. The high demand for the generation of sophisticated mouse models of human disease by NNE-CTR members and other regional translational researchers, combined with new faculty recruitment at MMCRI and increased use of animal models by current faculty, has resulted in the need to expand animal housing space in our barrier animal facility at MMCRI. The proposed renovation will convert a storage room into an additional mouse housing room, and convert space adjacent to the animal facility into a storage area. The renovation to create a new mouse housing room will require extensive changes to the HVAC system, and moving doors to bring the new animal room inside the barrier portion of the animal facility. The expansion will accommodate housing of new mouse models developed for NNE-CTR members, as well as other translational investigators in the region. By expanding mouse housing facilities, both the generation of new mouse models and the experimental protocols to investigate these new mouse models will be advanced more rapidly and cost-effectively.