Phase III COBRE in Vascular Biology

血管生物学COBRE成立于2000年，目的是了解血管重塑和疾病的机制。在COBRE支持的过去两个资助期内，我们已经建立了一个成功的协作，独立的心血管生物学研究人员中心。我们的科学进步不可或缺的是在支持我们研究项目成功的关键领域建立机构核心设施。本申请中描述的核心设施已经发展成为广泛使用的机构和区域资源，这些资源增加了科学合作，提高了我们研究的质量和影响，从而提高了我们研究人员的竞争力。第三期COBRE过渡支持申请旨在进一步加强四个现有核心设施的自我可持续发展，同时提供试点项目支持，以促进使用最先进战略的合作研究。该COBRE在I-II阶段的成功包括组建了一个高度协作的研究团队，专注于血管生物学中相互关联的主题，为每位研究人员获得独立的校外资助，开发了一个由内部和外部顾问提供意见的指导计划，以及开发了重要的研究基础设施，以支持缅因医学中心研究所（MMCRl）所有研究项目的目标。该申请的具体目标是：1)保持对所有研究人员、受训人员和工作人员的指导和培训；2)促进促进科学卓越的合议、智力刺激的环境；3)通过基础设施改善、高级培训和财务可持续性保持中心在血管研究方面的前沿地位；4)通过试点项目计划促进合作和增加资助机会。这些目标将通过保持最先进的研究技术和专业知识，并通过多研究者合作和项目资助，继续推动该项目向全国突出发展。我们的生物医学研究项目也有助于NIH改善国民健康的使命，我们的重点是了解疾病的机制。

The COBRE in Vascular Biology was established in 2000 with the goal of understanding the mechanisms of vascular remodeling and disease. In the past two funding periods of COBRE support, we have built a successful center of collaborative, independent cardiovascular biology researchers. Integral to our scientific progress was the establishment of institutional core facilities in areas critical to support success of our research program. The core facilities described in this application have developed into widely used institutional and regional resources that have increased scientific collaboration, the quality and impact of our research, and thus the competitiveness of our investigators. This Phase III COBRE application for transitional support aims to further enhance four existing core facilities towards self-sustainability, while additionally providing pilot project support to foster collaborative research using state-of-the-art strategies. The successes of this COBRE in Phases I-II included the assembly of a highly collaborative team of investigators focused on inter-related themes in vascular biology, achievement of independent extramural funding for each investigator, development of a mentoring program with input from both internal and external advisors, and the development of significant research infrastructure to support the goals of all research programs at Maine Medical Center Research Institute (MMCRl). The specific aims of this application are: 1) to maintain mentorship and training of all Center investigators, trainees, and staff, 2) to promote a collegial, intellectually stimulating environment that fosters scientific excellence, 3) to maintain the Center at the cutting edge of vascular research through infrastructure improvements, advanced training, and financial sustainability, and 4) to stimulate collaborations and enhance grant funding opportunities through a pilot project program. These aims will continue to advance this program towards national prominence by maintaining state-of-the art research technologies and expertise, and toward self-sufficiency through collaborative multi-investigator and program grants. Our biomedical research programs also contribute to the NIH mission to improve the nation's health, with our focus on understanding mechanisms of disease.