Phase III COBRE in Vascular Biology

血管生物学 III 期 COBRE

• 批准号: 8435447
• 负责人: ROBERT E FRIESEL
• 金额: $ 107.82万
• 依托单位: MAINEHEALTH
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-15 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8435447
• 关键词: Achievement; Area; Biology; Biomedical Research; Blood Vessels; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Cell Differentiation process; Centers of Research Excellence; Collaborations; Core Facility; Development; Diagnostic; Disease; Environment; Extramural Activities; Fostering; Funding; Funding Opportunities; Goals; Grant; Health; Lead; Maine; Medical center; Mentors; Mentorship; Mission; Molecular; Phase; Pilot Projects; Research; Research Infrastructure; Research Institute; Research Personnel; Resources; Technology; Therapeutic; Training; United States; United States National Institutes of Health; Vascular Diseases; Vascular remodeling; cell growth; combat; disability; improved; interdisciplinary approach; programs; success

The COBRE in Vascular Biology was established in 2000 with the goal of understanding the mechanisms of vascular remodeling and disease. In the past two funding periods of COBRE support, we have built a successful center of collaborative, independent cardiovascular biology researchers. Integral to our scientific progress was the establishment of institutional core facilities in areas critical to support success of our research program. The core facilities described in this application have developed into widely used institutional and regional resources that have increased scientific collaboration, the quality and impact of our research, and thus the competitiveness of our investigators. This Phase III COBRE appplication for transitional support aims to further enhance four existing core facilities towards self-sustainability, while additionally providing pilot project support to foster collaborative research using state-of-the-art strategies. The successes of this COBRE in Phases I-II included the assembly of a highly collaborative team of investigators focused on inter-related themes in vascular biology, achievement of independent extramural funding for each investigator, development of a mentoring program with input from both internal and external advisors, and the development of significant research infrastructure to support the goals of all research programs at Maine Medical Center Research Institute (MMCRI). The specific aims of this application are: 1) to maintain mentorship and training of all Center investigators, trainees, and staff, 2) to promote a collegial, intellectually stimulating environment that fosters scientific excellence, 3) to maintain the Center at the cutting edge of vascular research through infrastructure improvements, advanced training, and financial sustainability, and 4) to stimulate collaborations and enhance grant funding opportunities through a pilot project program. These aims will continue to advance this program towards national prominence by maintaining state-of-the art research technologies and expertise, and toward self-sufficiency through collaborative multi-investigator and program grants. Our biomedical research programs also contribute to the NIH mission to improve the nation's health, with our focus on understanding mechanisms of disease.

血管生物学 COBRE 成立于 2000 年，旨在了解血管重塑和疾病的机制。在 COBRE 支持的过去两个资助期中，我们成功建立了一个由协作、独立的心血管生物学研究人员组成的中心。我们的科学进步不可或缺的一部分是在支持我们研究计划成功的关键领域建立机构核心设施。本申请中描述的核心设施已发展成为广泛使用的机构和区域资源，提高了科学合作、我们研究的质量和影响力，从而提高了我们研究人员的竞争力。第三阶段 COBRE 过渡支持申请旨在进一步增强四个现有核心设施的自我可持续性，同时另外提供试点项目支持，以利用最先进的策略促进合作研究。 COBRE 在 I-II 阶段的成功包括组建了一个高度协作的研究人员团队，专注于血管生物学中相互关联的主题，为每位研究人员获得独立的外部资助，在内部和外部顾问的投入下制定指导计划，以及开发重要的研究基础设施以支持缅因州医学中心研究所 (MMCRI) 所有研究项目的目标。该申请的具体目标是：1) 维持对所有中心研究人员、受训人员和工作人员的指导和培训，2) 促进一个学院式的、智力刺激的环境，以促进科学卓越，3) 通过基础设施改善、高级培训和财务可持续性，保持中心在血管研究的前沿，4) 通过试点项目计划刺激合作并增加资助机会。这些目标将通过保持最先进的研究技术和专业知识，继续推动该计划在全国范围内发挥主导作用，并通过多研究者合作和计划拨款实现自给自足。我们的生物医学研究项目也为 NIH 改善国民健康的使命做出了贡献，重点是了解疾病机制。