COBRE in Vascular Biology

COBRE 在血管生物学中的应用

• 批准号: 7919721
• 负责人: ROBERT E FRIESEL
• 金额: $ 20.12万
• 依托单位: MAINEHEALTH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-17 至 2011-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7919721
• 关键词: COBRE; Vascular; Biology

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To enhance data analysis capacity of small animal imaging core facility by providing full-time employment for data analyst and enhancing the computational power for large data file throughput.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 通过为数据分析师提供全职工作并增强大数据文件吞吐量的计算能力，增强小动物成像核心设施的数据分析能力。

项目成果

Inhibition of tumor-associated αvβ3 integrin regulates the angiogenic switch by enhancing expression of IGFBP-4 leading to reduced melanoma growth and angiogenesis in vivo.

• DOI: 10.1007/s10456-014-9445-2
• 发表时间: 2015-01
• 期刊: ANGIOGENESIS
• 影响因子: 9.8
• 作者: Contois, Liangru W.;Akalu, Abebe;Caron, Jennifer M.;Tweedie, Eric;Cretu, Alexandra;Henderson, Terry;Liaw, Lucy;Friesel, Robert;Vary, Calvin;Brooks, Peter C.
• 通讯作者: Brooks, Peter C.

Conditional expression of Spry1 in neural crest causes craniofacial and cardiac defects.

• DOI: 10.1186/1471-213x-10-48
• 发表时间: 2010-05-11
• 期刊: BMC developmental biology
• 作者: Yang X;Kilgallen S;Andreeva V;Spicer DB;Pinz I;Friesel R
• 通讯作者: Friesel R

Endoglin is required in Pax3-derived cells for embryonic blood vessel formation.

• DOI: 10.1016/j.ydbio.2015.10.019
• 发表时间: 2016-01-01
• 期刊: Developmental biology
• 影响因子: 2.7
• 作者: Young K;Krebs LT;Tweedie E;Conley B;Mancini M;Arthur HM;Liaw L;Gridley T;Vary C
• 通讯作者: Vary C

Spry1 is expressed in hemangioblasts and negatively regulates primitive hematopoiesis and endothelial cell function.

• DOI: 10.1371/journal.pone.0018374
• 发表时间: 2011-04-01
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Yang X;Gong Y;Friesel R
• 通讯作者: Friesel R

RhoA-mediated signaling in Notch-induced senescence-like growth arrest and endothelial barrier dysfunction.

• DOI: 10.1161/atvbaha.110.221945
• 发表时间: 2011-04
• 期刊: Arteriosclerosis, thrombosis, and vascular biology
• 作者: Venkatesh D;Fredette N;Rostama B;Tang Y;Vary CP;Liaw L;Urs S
• 通讯作者: Urs S