PHASE III COBRE IN VASCULAR BIOLOGY

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 血管生物学COBRE成立于2000年，旨在了解血管重塑和疾病的机制。在Cobre支持的过去两个资助期，我们成功地建立了一个合作的、独立的心血管生物学研究人员中心。我们的科学进步不可或缺的是在支持我们研究计划成功的关键领域建立机构核心设施。本申请中描述的核心设施已发展成为广泛使用的机构和区域资源，增加了科学合作，提高了我们研究的质量和影响，从而提高了我们研究人员的竞争力。Cobre申请过渡支持的第三阶段旨在进一步加强现有的四个核心设施，以实现自我维持，同时提供试点项目支持，以促进使用最先进战略的合作研究。Cobre在第一-第二阶段取得的成功包括组建了一个高度合作的研究团队，专注于血管生物学中相互关联的主题，为每位研究人员提供独立的外部资金，制定了一个由内部和外部顾问提供意见的指导计划，以及开发了重要的研究基础设施，以支持缅因州医学中心研究所(MMCRl)所有研究计划的目标。这项申请的具体目标是：1)保持对所有中心研究人员、受训人员和工作人员的指导和培训；2)促进合作、激励智力的环境，促进卓越的科学；3)通过基础设施改进、高级培训和财务可持续性，保持中心在血管研究方面的领先地位；4)通过试点项目计划刺激合作和增加赠款资助机会。这些目标将继续通过保持最先进的研究技术和专业知识来推动该计划走向全国显赫地位，并通过合作的多名研究人员和计划拨款实现自给自足。我们的生物医学研究项目也为NIH改善国民健康的使命做出了贡献，我们的重点是了解疾病的机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The COBRE in Vascular Biology was established in 2000 with the goal of understanding the mechanisms of vascular remodeling and disease. In the past two funding periods of COBRE support, we have built a successful center of collaborative, independent cardiovascular biology researchers. Integral to our scientific progress was the establishment of institutional core facilities in areas critical to support success of our research program. The core facilities described in this application have developed into widely used institutional and regional resources that have increased scientific collaboration, the quality and impact of our research, and thus the competitiveness of our investigators. This Phase III COBRE application for transitional support aims to further enhance four existing core facilities towards self-sustainability, while additionally providing pilot project support to foster collaborative research using state-of-the-art strategies. The successes of this COBRE in Phases I-II included the assembly of a highly collaborative team of investigators focused on inter-related themes in vascular biology, achievement of independent extramural funding for each investigator, development of a mentoring program with input from both internal and external advisors, and the development of significant research infrastructure to support the goals of all research programs at Maine Medical Center Research Institute (MMCRl). The specific aims of this application are: 1) to maintain mentorship and training of all Center investigators, trainees, and staff, 2) to promote a collegial, intellectually stimulating environment that fosters scientific excellence, 3) to maintain the Center at the cutting edge of vascular research through infrastructure improvements, advanced training, and financial sustainability, and 4) to stimulate collaborations and enhance grant funding opportunities through a pilot project program. These aims will continue to advance this program towards national prominence by maintaining state-of-the art research technologies and expertise, and toward self-sufficiency through collaborative multi-investigator and program grants. Our biomedical research programs also contribute to the NIH mission to improve the nation's health, with our focus on understanding mechanisms of disease.