Internet-based insomnia intervention to prevent cognitive decline in older adults with mild cognitive impairment

梅根·马托斯博士是一名护士科学家，曾接受过老年护理、痴呆症护理和管理方面的培训， 睡眠障碍、数字健康与临床专业知识相结合的神经疾病患者的护理 精神错乱。她目前的研究、研究资金和传播史证明了她有能力 在有认知障碍的老年人中进行创新、有影响力的研究，特别是为了提高质量 生命和疾病的轨迹。马托斯医生的短期职业目标是成为一名独立护士 研究人员专注于在老年人中使用数字健康，并通过额外的正式 领导力培训。她广泛的、长期的职业目标是通过 互联网为老年人维持认知健康和幸福感。所提供的培训和指导 NIA Beeson老年职业发展奖将使她获得专业知识并在 使用数字疗法和基于互联网的招募进行严格的阿尔茨海默病试验 方法：研究方法。该项目将在一位杰出的和免费的指导下进行 数字健康和基于互联网的招聘的国际领导者(Lee Ritterband博士)， 评估老龄化和慢性病的健康结果(史蒂文·阿尔伯特博士)，护士创新者和 认知障碍的领导者(詹妮弗·林格勒博士)。弗吉尼亚大学致力于马托斯博士的 发展成为一名在团队科学中工作的护士科学家并提供必要的设施和资源 进行拟议的研究项目。在马托斯博士和她的团队初步工作的基础上， 拟议的随机对照试验将评估互联网传递的认知行为的影响 失眠治疗(CBT-I)对睡眠的干预及其对认知健康的贡献 有轻度认知障碍的个体。符合轻度失眠研究标准的失眠患者 将招募认知障碍来确定CBT-I干预与患者相比的效果 睡眠和认知方面的教育控制条件。将使用基于互联网的招聘方法，以及 结果包括睡眠变量(总体失眠严重程度降低和入睡后醒来)、白天 变量(疲劳度降低、生活质量提高、情绪改善)和认知状态 (记忆、注意力/精神运动速度和执行功能领域)。这项提议将为未来提供一个 随机对照试验旨在检测干预对认知下降斜率的影响以及 为马托斯博士提供以下方面的培训：1)进行严格和可重复的试验；2)领导招募 在老年人中使用基于互联网的设置和进行数字健康试验的努力。比森的职业生涯 老龄发展奖 将允许马托斯博士 参与正式的领导机会 在国内和国际层面推进老年护理，建立独立的职业生涯 有认知障碍的老年人的数字健康。

Dr. Meghan Mattos is a nurse scientist with training in gerontological nursing, dementia care and management, sleep disorders, and digital health combined with clinical expertise in the care of patients with neurological disorders. Her current research, research funding, and history of dissemination demonstrate her ability to execute innovative, impactful research in older adults with cognitive impairment, specifically to improve quality of life and disease trajectory. Dr. Mattos’s short-term career goals are to become an independent nurse researcher focused on the use of digital health in older adults and grow as a leader through additional formal leadership training. Her broad, long-term career goal is to implement effective, accessible interventions via the Internet for older adults to maintain cognitive health and well-being. The training and mentorship afforded by the NIA Beeson Career Development Award in Aging will allow her to gain expertise and receive mentorship in the conduct of rigorous Alzheimer’s disease trials using digital therapeutics and Internet-based recruitment methods. This project will be conducted under the outstanding and complimentary mentorship of an international leader in digital health and Internet-based recruitment (Dr. Lee Ritterband), leader in the assessment of health outcomes in aging and chronic disease (Dr. Steven Albert), and nurse innovator and leader in cognitive impairment (Dr. Jennifer Lingler). The University of Virginia is committed to Dr. Mattos’s development as a nurse scientist working in team science and provides the necessary facilities and resources to conduct the proposed research project. Building upon Dr. Mattos and her team’s preliminary work, the proposed randomized controlled trial will evaluate the impact of an Internet-delivered cognitive behavioral therapy for insomnia (CBT-I) intervention on sleep and the extent to which it contributes to cognitive health in individuals with mild cognitive impairment. Participants with insomnia who meet the study criteria for mild cognitive impairment will be recruited to determine the effects of the CBT-I intervention compared to a patient education control condition on sleep and cognition. Internet-based recruitment methods will be used, and outcomes include sleep variables (reduced overall insomnia severity and wake after sleep onset), daytime variables (reduced levels of fatigue, improved quality of life, and improved mood), and cognitive status (memory, attention/psychomotor speed, and executive functioning domains). This proposal will inform a future randomized controlled trial powered to detect the intervention effect on the slope of cognitive decline as well as provide Dr. Mattos training in 1) the conduct of rigorous and reproducible trials and 2) leading recruitment efforts using Internet-based settings and conducting digital health trials in older adults. The Beeson Career Development Award in Aging will allow Dr. Mattos to engage in formal opportunities for leadership at the national and international levels to advance gerontological nursing and establish her independent career in digital health for older adults with cognitive impairment.