Internet-based insomnia intervention to prevent cognitive decline in older adults with mild cognitive impairment

Meghan Mattos博士是一名护士科学家，接受过老年护理、痴呆症护理和管理方面的培训， 睡眠障碍，数字健康与神经系统疾病患者护理的临床专业知识相结合 紊乱她目前的研究，研究资金和传播历史证明她有能力 在有认知障碍的老年人中开展创新的、有影响力的研究，特别是为了提高质量 生命和疾病轨迹的变化。马托斯医生的短期职业目标是成为一名独立的护士 研究人员专注于在老年人中使用数字健康，并通过其他正式的 领导力培训。她广泛的，长期的职业目标是通过实施有效的，可访问的干预措施， 互联网为老年人保持认知健康和福祉。提供的培训和指导， NIA Beeson老龄化职业发展奖将使她获得专业知识并接受以下方面的指导： 使用数字疗法和基于互联网的招募进行严格的阿尔茨海默病试验 方法.这个项目将在一位杰出的和免费的指导下进行， 数字健康和基于互联网的招聘的国际领导者（Lee Ritterband博士） 老年人和慢性病的健康结果评估（史蒂芬阿尔伯特博士），护士创新者和 认知障碍的领导者（詹妮弗·林格勒博士）。弗吉尼亚大学致力于马托斯博士的 作为一名护理科学家，在团队科学中工作，并提供必要的设施和资源 进行拟议的研究项目。在马托斯博士和她的团队的初步工作的基础上， 一项拟议的随机对照试验将评估互联网提供的认知行为 失眠治疗（CBT-I）对睡眠的干预及其对认知健康的贡献程度 有轻度认知障碍的人。符合轻度失眠研究标准的失眠参与者 将招募认知障碍患者，以确定CBT-I干预与患者相比的效果 教育控制状况对睡眠和认知的影响。将使用基于互联网的征聘方法， 结果包括睡眠变量（降低整体失眠严重程度和睡眠后觉醒），白天 变量（疲劳程度降低、生活质量改善和情绪改善）和认知状态 （记忆、注意力/心理速度和执行功能领域）。这一建议将为未来的 一项随机对照试验，旨在检测干预对认知能力下降斜率的影响， 为Mattos博士提供以下方面的培训：1）进行严格和可重复的试验; 2）领导招聘 努力使用基于互联网的设置和进行数字健康试验的老年人。Beeson职业生涯 老龄化发展奖 能让马托斯博士 参与正式的领导机会， 在国家和国际各级促进老年护理， 为有认知障碍的老年人提供数字健康。

Dr. Meghan Mattos is a nurse scientist with training in gerontological nursing, dementia care and management, sleep disorders, and digital health combined with clinical expertise in the care of patients with neurological disorders. Her current research, research funding, and history of dissemination demonstrate her ability to execute innovative, impactful research in older adults with cognitive impairment, specifically to improve quality of life and disease trajectory. Dr. Mattos’s short-term career goals are to become an independent nurse researcher focused on the use of digital health in older adults and grow as a leader through additional formal leadership training. Her broad, long-term career goal is to implement effective, accessible interventions via the Internet for older adults to maintain cognitive health and well-being. The training and mentorship afforded by the NIA Beeson Career Development Award in Aging will allow her to gain expertise and receive mentorship in the conduct of rigorous Alzheimer’s disease trials using digital therapeutics and Internet-based recruitment methods. This project will be conducted under the outstanding and complimentary mentorship of an international leader in digital health and Internet-based recruitment (Dr. Lee Ritterband), leader in the assessment of health outcomes in aging and chronic disease (Dr. Steven Albert), and nurse innovator and leader in cognitive impairment (Dr. Jennifer Lingler). The University of Virginia is committed to Dr. Mattos’s development as a nurse scientist working in team science and provides the necessary facilities and resources to conduct the proposed research project. Building upon Dr. Mattos and her team’s preliminary work, the proposed randomized controlled trial will evaluate the impact of an Internet-delivered cognitive behavioral therapy for insomnia (CBT-I) intervention on sleep and the extent to which it contributes to cognitive health in individuals with mild cognitive impairment. Participants with insomnia who meet the study criteria for mild cognitive impairment will be recruited to determine the effects of the CBT-I intervention compared to a patient education control condition on sleep and cognition. Internet-based recruitment methods will be used, and outcomes include sleep variables (reduced overall insomnia severity and wake after sleep onset), daytime variables (reduced levels of fatigue, improved quality of life, and improved mood), and cognitive status (memory, attention/psychomotor speed, and executive functioning domains). This proposal will inform a future randomized controlled trial powered to detect the intervention effect on the slope of cognitive decline as well as provide Dr. Mattos training in 1) the conduct of rigorous and reproducible trials and 2) leading recruitment efforts using Internet-based settings and conducting digital health trials in older adults. The Beeson Career Development Award in Aging will allow Dr. Mattos to engage in formal opportunities for leadership at the national and international levels to advance gerontological nursing and establish her independent career in digital health for older adults with cognitive impairment.