Internet-based insomnia intervention to prevent cognitive decline in older adults with mild cognitive impairment

基于互联网的失眠干预预防轻度认知障碍老年人认知能力下降

• 批准号: 10672245
• 负责人: Meghan K Mattos
• 金额: $ 24.3万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10672245
• 关键词: Adult; Advertisements; Affect; Aging; Alzheimer' s Disease; Attention; Chronic Disease; Chronic Insomnia; Clinical; Clinical Trials; Clinical Trials Design; Cognition; Cognitive; Cognitive Therapy; Collection; Coupled; Development; Disease; Elderly; Fatigue; Feeling; Funding; Future; Geriatric Nursing; Gerontology; Goals; Health; Hour; Impaired cognition; Impairment; Individual; International; Internet; Intervention; K-Series Research Career Programs; Leadership; Left; Measures; Memory; Mentorship; Methods; Moods; Neuropsychology; Nurses; Outcome; Participant; Patient Care; Patient Education; Patient Recruitments; Patients; Personal Satisfaction; Persons; Population; Populations at Risk; Positioning Attribute; Provider; Psychomotor Performance; Public Health; Quality of life; Randomized, Controlled Trials; Recommendation; Recording of previous events; Reproducibility; Research; Research Personnel; Research Project Grants; Resources; Role; Science; Scientist; Severities; Sleep; Sleep Disorders; Sleeplessness; Speed; Symptoms; Technology; Time; Training; Translating; Travel; Universities; Virginia; Work; acceptability and feasibility; adverse outcome; arm; career; cognitive performance; comparison intervention; dementia care; digital health; digital treatment; efficacy evaluation; efficacy testing; executive function; experience; falls; follow-up; fortification; health assessment; improved; improvement on sleep; innovation; instrument; intervention effect; mild cognitive impairment; nervous system disorder; pharmacologic; post intervention; preservation; prevent; programs; randomized trial; recruit; sleep onset; social networking website; success; trial design

Dr. Meghan Mattos is a nurse scientist with training in gerontological nursing, dementia care and management, sleep disorders, and digital health combined with clinical expertise in the care of patients with neurological disorders. Her current research, research funding, and history of dissemination demonstrate her ability to execute innovative, impactful research in older adults with cognitive impairment, specifically to improve quality of life and disease trajectory. Dr. Mattos’s short-term career goals are to become an independent nurse researcher focused on the use of digital health in older adults and grow as a leader through additional formal leadership training. Her broad, long-term career goal is to implement effective, accessible interventions via the Internet for older adults to maintain cognitive health and well-being. The training and mentorship afforded by the NIA Beeson Career Development Award in Aging will allow her to gain expertise and receive mentorship in the conduct of rigorous Alzheimer’s disease trials using digital therapeutics and Internet-based recruitment methods. This project will be conducted under the outstanding and complimentary mentorship of an international leader in digital health and Internet-based recruitment (Dr. Lee Ritterband), leader in the assessment of health outcomes in aging and chronic disease (Dr. Steven Albert), and nurse innovator and leader in cognitive impairment (Dr. Jennifer Lingler). The University of Virginia is committed to Dr. Mattos’s development as a nurse scientist working in team science and provides the necessary facilities and resources to conduct the proposed research project. Building upon Dr. Mattos and her team’s preliminary work, the proposed randomized controlled trial will evaluate the impact of an Internet-delivered cognitive behavioral therapy for insomnia (CBT-I) intervention on sleep and the extent to which it contributes to cognitive health in individuals with mild cognitive impairment. Participants with insomnia who meet the study criteria for mild cognitive impairment will be recruited to determine the effects of the CBT-I intervention compared to a patient education control condition on sleep and cognition. Internet-based recruitment methods will be used, and outcomes include sleep variables (reduced overall insomnia severity and wake after sleep onset), daytime variables (reduced levels of fatigue, improved quality of life, and improved mood), and cognitive status (memory, attention/psychomotor speed, and executive functioning domains). This proposal will inform a future randomized controlled trial powered to detect the intervention effect on the slope of cognitive decline as well as provide Dr. Mattos training in 1) the conduct of rigorous and reproducible trials and 2) leading recruitment efforts using Internet-based settings and conducting digital health trials in older adults. The Beeson Career Development Award in Aging will allow Dr. Mattos to engage in formal opportunities for leadership at the national and international levels to advance gerontological nursing and establish her independent career in digital health for older adults with cognitive impairment.

梅根·马托斯 (Meghan Mattos) 博士是一名护士科学家，接受过老年护理、痴呆症护理和管理方面的培训， 睡眠障碍、数字健康与神经系统疾病患者护理的临床专业知识相结合 失调。她目前的研究、研究经费和传播历史证明了她的能力 对患有认知障碍的老年人进行创新、有影响力的研究，特别是为了提高质量 生命和疾病的轨迹。马托斯博士的短期职业目标是成为一名独立护士 研究人员专注于老年人数字健康的使用，并通过额外的正式培训成长为领导者 领导力培训。她广泛、长期的职业目标是通过以下方式实施有效、可及的干预措施： 互联网帮助老年人保持认知健康和福祉。提供的培训和指导 NIA Beeson 老龄化职业发展奖将使她能够获得专业知识并接受以下方面的指导： 使用数字疗法和基于互联网的招募进行严格的阿尔茨海默病试验 方法。该项目将在一位杰出和免费的指导下进行 数字健康和互联网招聘领域的国际领导者（Lee Ritterband 博士）， 评估衰老和慢性疾病的健康结果（史蒂文·阿尔伯特博士），以及护士创新者和 认知障碍领域的领导者（Jennifer Lingler 博士）。弗吉尼亚大学致力于马托斯博士的 发展成为一名从事团队科学工作的护士科学家，并提供必要的设施和资源 进行拟议的研究项目。在 Mattos 博士和她的团队的前期工作的基础上， 拟议的随机对照试验将评估互联网提供的认知行为的影响 失眠疗法（CBT-I）对睡眠的干预及其对认知健康的贡献程度 患有轻度认知障碍的人。符合轻度失眠研究标准的参与者 将招募认知障碍患者来确定 CBT-I 干预与患者相比的效果 教育控制睡眠和认知状况。将采用基于互联网的招聘方式，并且 结果包括睡眠变量（总体失眠严重程度降低和入睡后醒来）、白天 变量（减轻疲劳程度、提高生活质量和改善情绪）和认知状态 （记忆力、注意力/精神运动速度和执行功能域）。该提案将为未来提供信息 随机对照试验旨在检测干预对认知能力下降斜率的影响以及 为 Mattos 博士提供以下方面的培训：1) 进行严格且可重复的试验；2) 领导招募 努力使用基于互联网的设置并在老年人中进行数字健康试验。比森职业生涯 老龄化发展奖 将允许马托斯博士 参与正式的领导机会 在国家和国际层面上推进老年护理并建立她的独立职业生涯 针对有认知障碍的老年人的数字健康。