Understanding and Engaging Families in HIV Biomedical Prevention for Latino Men Who Have Sex with Men

了解并让家庭参与针对男男性行为拉丁裔男性的艾滋病毒生物医学预防

• 批准号: 10524046
• 负责人: Homero Erwin del Pino
• 金额: $ 12.95万
• 依托单位: CHARLES R. DREW UNIVERSITY OF MED & SCI
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-29 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10524046
• 关键词: AIDS prevention; Address; Adolescent; Affect; Award; Behavior; Biometry; Blood; Chicago; Cities; Clinic; Clinical Research; Cohort Studies; Collaborations; Complex; Cross-Sectional Studies; Data; Data Analyses; Development; Disparity; Effectiveness; Eligibility Determination; Emotional; Ethnic Population; Family; Family Relationship; Family member; Federally Qualified Health Center; Focus Groups; Funding; Goals; HIV; HIV Infections; HIV diagnosis; HIV disparities; HIV/AIDS; Health; Health behavior and outcomes; Heterosexuals; Homophobia; Human immunodeficiency virus test; Individual; Infrastructure; Intervention; Interview; Knowledge; Latino; Latino Population; Long-Term Effects; Longevity; Los Angeles; Medicine; Mental Health; Mentors; Mentorship; Minority; Motivation; National Center for Advancing Translational Sciences; National Institute of Drug Abuse; National Institute of Mental Health; National Institute on Minority Health and Health Disparities; Paper; Perception; Pharmacy facility; Philosophy; Prevention; Procedures; Process; Prospective, cohort study; Public Health; Publishing; Reporting; Research; Research Personnel; Research Priority; Resources; Risk; Risk Behaviors; Risk Reduction; Safe Sex; Science; Sex Behavior; Sexual and Gender Minorities; Siblings; Social support; Source; System; Testing; Theoretical model; Time; Training; Translational Research; Universities; Urine; Viral; Viral Load result; Work; Youth; acceptability and feasibility; behavior change; career; career development; clinical center; clinical epidemiology; cohort; design; efficacy testing; epidemiology study; experience; family support; follow-up; gender minority community; health disparity; high risk; high risk men; intervention refinement; men of color; men who have sex with men; mid-career faculty; physical conditioning; pilot test; pre-exposure prophylaxis; prevent; prevention service; preventive intervention; public health research; racial population; recruit; social stigma; stem; substance use; therapy development; treatment services; uptake; willingness

Project Summary/Abstract Candidate: This K01 is submitted by Dr. del Pino, Associate Professor, from Charles R. Drew University of Medicine and Science (CDU). This proposal is the next step in his transition from philosophy to public health research. He seeks to reduce HIV disparities among Latino men who have sex with men (MSM) by analyzing family support data from three prospective cohort studies in Los Angeles and Chicago and by conducting formative research to leverage the siblings of Latino MSM in an HIV biomedical prevention intervention. He has published qualitative and quantitative papers on family support, substance use, and HIV. He is currently supported by the CDU Emerging Scholars Award and CRECD. Career Development and Training Plan: Dr. del Pino's mentoring team includes Dr. Steve Shoptaw (expert in substance use and biomedical interventions), Dr. Nina Harawa (expert in the development of culturally responsive HIV-prevention interventions for MSM of color), and Dr. Arun Karlamangla (expert in complex biostatistical data analysis and longitudinal clinical epidemiology research). The training goals (advanced biostatistics, families and stigma, and intervention development) will be achieved through coursework and individual tutorials with each mentor. He will have access to the UCLA CTSI (NCATS); UCLA CHIPTS (NIMH); and to AXIS, CDU's center for clinical and translational research resources and trainings (NIMHD). Research Plan: Despite the prevention and treatment efforts of the past 30 years, Latino MSM continue to be disproportionately impacted by HIV. Yet a powerful cultural source of motivation has been underutilized: the family. This project seeks to address HIV disparities by addressing gaps in our knowledge of (a) how family support affects the behaviors and health of Latino MSM over time and (b) how to engage siblings in the development and delivery of PrEP-use messages. Aim 1: Determine how family support and mental health affect the HIV-related behaviors (e.g., substance use, sexual risk) and HIV-related health (e.g., STI, HIV viral load) of Latino MSM over time. Hypothesis: Latino MSM with greater family support over time will report better HIV-related risk behaviors and health outcomes than Latino MSM who report little to no family support. Aim 2: Identify barriers and facilitators to engaging Latino MSM and siblings in HIV biomedical interventions. Aim 3: Develop and pilot test sibling-delivered messages to increase PrEP use in high-risk Latino MSM to gather feasibility and acceptability data and to refine the intervention processes and messages. Summary: The Career Development and Training Plan and the Research Plan will prepare Dr. del Pino to submit an R01 to test the efficacy and effectiveness of a culturally-specific, sibling-based intervention to reduce HIV disparities among Latino MSM. His mentorship team has the required expertise and established record of mentoring junior researchers to ensure that he becomes an independently-funded investigator.

项目总结/摘要 候选人：本K 01由Charles R.德鲁大学 医学和科学（CDU）。这个提议是他从哲学转向公共卫生的下一步 research.他试图通过分析， 来自洛杉矶和芝加哥三项前瞻性队列研究的家庭支持数据， 形成性研究，以利用拉丁美洲男男性行为者的兄弟姐妹在艾滋病毒生物医学预防干预。他 发表了关于家庭支持、药物使用和艾滋病毒的定性和定量论文。现任 由CDU新兴学者奖和CRECD支持。 职业发展和培训计划：del Pino博士的指导团队包括Steve Shoptaw博士（专家 Nina Harawa博士（文化发展方面的专家） 针对有色人种男男性接触者的艾滋病毒预防干预措施）和Arun Karlamangla博士（复杂 生物统计数据分析和纵向临床流行病学研究）。培训目标（高级） 生物统计学，家庭和耻辱，和干预发展）将通过课程和 每个导师的个人教程。他将有机会获得加州大学洛杉矶分校CTSI（NCATS）;加州大学洛杉矶分校芯片（NIMH）; 以及CDU的临床和转化研究资源和培训中心（NIMHD）。 研究计划：尽管过去30年的预防和治疗努力，拉丁美洲男男性接触者继续是 受艾滋病毒的严重影响。然而，一个强大的文化动力来源却没有得到充分利用： 家人该项目旨在通过解决我们在以下方面的知识差距来解决艾滋病毒方面的差距：（a）家庭如何 随着时间的推移，支持会影响拉丁裔男男性接触者的行为和健康，以及（B）如何让兄弟姐妹参与到 制定和提供PrEP使用信息。 目的1：确定家庭支持和心理健康如何影响艾滋病毒相关行为（例如，物质使用， 性风险）和艾滋病毒相关健康（例如，性病，艾滋病毒载量）的拉丁美洲男男性接触者随着时间的推移。标签：Latino MSM 随着时间的推移，家庭支持越多，报告的艾滋病毒相关风险行为和健康结果越好， 拉丁裔男同性恋者很少或没有家庭支持。目标2：确定参与拉丁美洲人的障碍和促进因素 艾滋病毒生物医学干预中的男男性行为者和兄弟姐妹。目标3：开发和试点测试兄弟姐妹传递的信息， 增加PrEP在高风险拉丁裔MSM中的使用，以收集可行性和可接受性数据，并完善 干预过程和信息。 概述：职业发展和培训计划以及研究计划将使del Pino博士做好准备， 提交R 01，以测试特定文化的、基于兄弟姐妹的干预措施的功效和有效性， 拉丁裔男男性行为者之间的艾滋病毒差异。他的导师团队拥有所需的专业知识和既定的记录， 指导初级研究人员，以确保他成为一个独立资助的调查员。