Understanding and Engaging Families in HIV Biomedical Prevention for Latino Men Who Have Sex with Men

了解并让家庭参与针对男男性行为拉丁裔男性的艾滋病毒生物医学预防

• 批准号: 9926760
• 负责人: Homero Erwin del Pino
• 金额: $ 12.95万
• 依托单位: CHARLES R. DREW UNIVERSITY OF MED & SCI
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-29 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9926760
• 关键词: AIDS prevention; AIDS/HIV problem; Address; Adolescent; Affect; Alcohol or Other Drugs use; Award; Behavior; Biometry; Blood; Chicago; Cities; Clinic; Clinical Research; Cohort Studies; Color; Complex; Data; Data Analyses; Development; Effectiveness; Emotional; Ensure; Family; Family Relationship; Family member; Federally Qualified Health Center; Focus Groups; Funding; Goals; HIV; HIV Infections; HIV diagnosis; HIV/STD; Health; Heterosexuals; Homophobia; Human immunodeficiency virus test; Individual; Infrastructure; Intervention; Interview; Knowledge; Latino; Long-Term Effects; Longevity; Los Angeles; Marshal; Medicine; Mental Health; Mentors; Mentorship; Minority; Modeling; Motivation; National Institute of Drug Abuse; National Institute of Mental Health; Outcome; Paper; Perception; Pharmacy facility; Philosophy; Prevention; Preventive Intervention; Procedures; Process; Prospective cohort study; Psyche structure; Public Health; Publishing; Reporting; Research; Research Personnel; Research Priority; Research Training; Resources; Risk; Risk Behaviors; Safe Sex; Science; Sex Behavior; Sexual and Gender Minorities; Siblings; Social support; Source; System; Testing; Time; Training; Translational Research; Universities; Urine; Viral; Viral Load result; Work; Youth; base; behavior change; career; career development; clinical center; clinical epidemiology; cohort; design; efficacy testing; epidemiology study; experience; family support; follow-up; health disparity; high risk; high risk men; men; men who have sex with men; mid-career faculty; minority communities; pre-exposure prophylaxis; prevent; prevention service; public health research; racial and ethnic; recruit; social stigma; stem; therapy development; treatment services; uptake; willingness

Project Summary/Abstract Candidate: This K01 is submitted by Dr. del Pino, Associate Professor, from Charles R. Drew University of Medicine and Science (CDU). This proposal is the next step in his transition from philosophy to public health research. He seeks to reduce HIV disparities among Latino men who have sex with men (MSM) by analyzing family support data from three prospective cohort studies in Los Angeles and Chicago and by conducting formative research to leverage the siblings of Latino MSM in an HIV biomedical prevention intervention. He has published qualitative and quantitative papers on family support, substance use, and HIV. He is currently supported by the CDU Emerging Scholars Award and CRECD. Career Development and Training Plan: Dr. del Pino's mentoring team includes Dr. Steve Shoptaw (expert in substance use and biomedical interventions), Dr. Nina Harawa (expert in the development of culturally responsive HIV-prevention interventions for MSM of color), and Dr. Arun Karlamangla (expert in complex biostatistical data analysis and longitudinal clinical epidemiology research). The training goals (advanced biostatistics, families and stigma, and intervention development) will be achieved through coursework and individual tutorials with each mentor. He will have access to the UCLA CTSI (NCATS); UCLA CHIPTS (NIMH); and to AXIS, CDU's center for clinical and translational research resources and trainings (NIMHD). Research Plan: Despite the prevention and treatment efforts of the past 30 years, Latino MSM continue to be disproportionately impacted by HIV. Yet a powerful cultural source of motivation has been underutilized: the family. This project seeks to address HIV disparities by addressing gaps in our knowledge of (a) how family support affects the behaviors and health of Latino MSM over time and (b) how to engage siblings in the development and delivery of PrEP-use messages. Aim 1: Determine how family support and mental health affect the HIV-related behaviors (e.g., substance use, sexual risk) and HIV-related health (e.g., STI, HIV viral load) of Latino MSM over time. Hypothesis: Latino MSM with greater family support over time will report better HIV-related risk behaviors and health outcomes than Latino MSM who report little to no family support. Aim 2: Identify barriers and facilitators to engaging Latino MSM and siblings in HIV biomedical interventions. Aim 3: Develop and pilot test sibling-delivered messages to increase PrEP use in high-risk Latino MSM to gather feasibility and acceptability data and to refine the intervention processes and messages. Summary: The Career Development and Training Plan and the Research Plan will prepare Dr. del Pino to submit an R01 to test the efficacy and effectiveness of a culturally-specific, sibling-based intervention to reduce HIV disparities among Latino MSM. His mentorship team has the required expertise and established record of mentoring junior researchers to ensure that he becomes an independently-funded investigator.

项目摘要/摘要 候选人：此K01由查尔斯·R·德鲁大学（Charles R. Drew）副教授Del Pino博士提交 医学与科学（CDU）。该提议是他从哲学到公共卫生过渡的下一步 研究。他试图通过分析与男性发生性关系的拉丁裔男人之间的艾滋病毒差异 来自洛杉矶和芝加哥的三项前瞻性队列研究的家庭支持数据以及进行 在HIV生物医学预防干预措施中利用拉丁裔MSM的兄弟姐妹的形成性研究。他有 发表了有关家庭支持，药物使用和艾滋病毒的定性和定量论文。他目前 得到CDU新兴学者奖和CRECD的支持。 职业发展和培训计划：Del Pino博士的指导团队包括Steve Shoptaw博士（专家 Nina Harawa博士（文化发展专家 MSM的响应艾滋病毒预防干预措施）和Arun Karlamangla博士（复杂的专家 生物统计数据分析和纵向临床流行病学研究）。培训目标（提前 生物统计学，家庭和污名以及干预发展）将通过课程和 每个导师的个人教程。他将可以使用UCLA CTSI（NCAT）； UCLA芯片（NIMH）; 以及CDU的临床和转化研究资源与培训中心（NIMHD）。 研究计划：尽管过去30年进行了预防和治疗工作，但拉丁裔MSM仍在 受艾滋病毒的影响不成比例。然而，强大的文化动机来源还没有得到充分利用： 家庭。该项目旨在通过解决（a）家庭如何解决我们的知识中的差距来解决艾滋病毒差异 支持会影响拉丁裔MSM的行为和健康，以及（b）如何使兄弟姐妹参与 开发和交付预先使用消息。 目标1：确定家庭支持和心理健康如何影响与HIV相关的行为（例如，使用物质， 随着时间的推移，性风险）和与HIV相关的健康（例如STI，HIV病毒负荷）。假设：拉丁裔MSM 随着时间的流逝，随着家庭的更多支持，将报告与HIV相关的风险行为和健康状况更好 拉丁裔MSM几乎没有家庭支持。瞄准2：确定障碍和促进者与拉丁裔的参与 MSM和HIV生物医学干预中的兄弟姐妹。目标3：开发和试点测试兄弟姐妹传递的消息 增加对高风险拉丁裔MSM的准备使用，以收集可行性和可接受性数据并完善 干预过程和消息。 摘要：职业发展和培训计划以及研究计划将为Del Pino博士做准备 提交R01，以测试基于文化的，基于同胞的干预措施的功效和有效性 拉丁裔MSM之间的艾滋病毒差异。他的指导团队具有所需的专业知识，并确定了 指导初级研究人员，以确保他成为一名独立资助的调查员。