Understanding and Engaging Families in HIV Biomedical Prevention for Latino Men Who Have Sex with Men

了解并让家庭参与针对男男性行为拉丁裔男性的艾滋病毒生物医学预防

• 批准号: 9926760
• 负责人: Homero Erwin del Pino
• 金额: $ 12.95万
• 依托单位: CHARLES R. DREW UNIVERSITY OF MED & SCI
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-29 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9926760
• 关键词: AIDS prevention; AIDS/HIV problem; Address; Adolescent; Affect; Alcohol or Other Drugs use; Award; Behavior; Biometry; Blood; Chicago; Cities; Clinic; Clinical Research; Cohort Studies; Color; Complex; Data; Data Analyses; Development; Effectiveness; Emotional; Ensure; Family; Family Relationship; Family member; Federally Qualified Health Center; Focus Groups; Funding; Goals; HIV; HIV Infections; HIV diagnosis; HIV/STD; Health; Heterosexuals; Homophobia; Human immunodeficiency virus test; Individual; Infrastructure; Intervention; Interview; Knowledge; Latino; Long-Term Effects; Longevity; Los Angeles; Marshal; Medicine; Mental Health; Mentors; Mentorship; Minority; Modeling; Motivation; National Institute of Drug Abuse; National Institute of Mental Health; Outcome; Paper; Perception; Pharmacy facility; Philosophy; Prevention; Preventive Intervention; Procedures; Process; Prospective cohort study; Psyche structure; Public Health; Publishing; Reporting; Research; Research Personnel; Research Priority; Research Training; Resources; Risk; Risk Behaviors; Safe Sex; Science; Sex Behavior; Sexual and Gender Minorities; Siblings; Social support; Source; System; Testing; Time; Training; Translational Research; Universities; Urine; Viral; Viral Load result; Work; Youth; base; behavior change; career; career development; clinical center; clinical epidemiology; cohort; design; efficacy testing; epidemiology study; experience; family support; follow-up; health disparity; high risk; high risk men; men; men who have sex with men; mid-career faculty; minority communities; pre-exposure prophylaxis; prevent; prevention service; public health research; racial and ethnic; recruit; social stigma; stem; therapy development; treatment services; uptake; willingness

Project Summary/Abstract Candidate: This K01 is submitted by Dr. del Pino, Associate Professor, from Charles R. Drew University of Medicine and Science (CDU). This proposal is the next step in his transition from philosophy to public health research. He seeks to reduce HIV disparities among Latino men who have sex with men (MSM) by analyzing family support data from three prospective cohort studies in Los Angeles and Chicago and by conducting formative research to leverage the siblings of Latino MSM in an HIV biomedical prevention intervention. He has published qualitative and quantitative papers on family support, substance use, and HIV. He is currently supported by the CDU Emerging Scholars Award and CRECD. Career Development and Training Plan: Dr. del Pino's mentoring team includes Dr. Steve Shoptaw (expert in substance use and biomedical interventions), Dr. Nina Harawa (expert in the development of culturally responsive HIV-prevention interventions for MSM of color), and Dr. Arun Karlamangla (expert in complex biostatistical data analysis and longitudinal clinical epidemiology research). The training goals (advanced biostatistics, families and stigma, and intervention development) will be achieved through coursework and individual tutorials with each mentor. He will have access to the UCLA CTSI (NCATS); UCLA CHIPTS (NIMH); and to AXIS, CDU's center for clinical and translational research resources and trainings (NIMHD). Research Plan: Despite the prevention and treatment efforts of the past 30 years, Latino MSM continue to be disproportionately impacted by HIV. Yet a powerful cultural source of motivation has been underutilized: the family. This project seeks to address HIV disparities by addressing gaps in our knowledge of (a) how family support affects the behaviors and health of Latino MSM over time and (b) how to engage siblings in the development and delivery of PrEP-use messages. Aim 1: Determine how family support and mental health affect the HIV-related behaviors (e.g., substance use, sexual risk) and HIV-related health (e.g., STI, HIV viral load) of Latino MSM over time. Hypothesis: Latino MSM with greater family support over time will report better HIV-related risk behaviors and health outcomes than Latino MSM who report little to no family support. Aim 2: Identify barriers and facilitators to engaging Latino MSM and siblings in HIV biomedical interventions. Aim 3: Develop and pilot test sibling-delivered messages to increase PrEP use in high-risk Latino MSM to gather feasibility and acceptability data and to refine the intervention processes and messages. Summary: The Career Development and Training Plan and the Research Plan will prepare Dr. del Pino to submit an R01 to test the efficacy and effectiveness of a culturally-specific, sibling-based intervention to reduce HIV disparities among Latino MSM. His mentorship team has the required expertise and established record of mentoring junior researchers to ensure that he becomes an independently-funded investigator.

项目总结/文摘