Behavioral Research Project:Promoting HIV PrEP among MSM: a Randomized Controlled Trial Protocol
行为研究项目:在 MSM 中推广 HIV PrEP:随机对照试验方案
基本信息
- 批准号:9978973
- 负责人:
- 金额:$ 24.78万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:AddressAgeAlcohol or Other Drugs useAwarenessBehaviorBehavioral ResearchCenters for Disease Control and Prevention (U.S.)ChildCommunitiesDataDevelopmentEmotionalEnrollmentFamilyFocus GroupsFoundationsFutureGoalsHIVHIV InfectionsHIV diagnosisHIV riskHealthHealth behaviorHeterosexualsIncidenceInterventionInterviewLatinoLiteratureLongevityMethodsModelingMotivationPharmaceutical PreparationsPilot ProjectsPre-Post TestsPreventionPrevention strategyProbabilityProceduresProcessProtocols documentationProviderRandomizedRandomized Controlled TrialsRecording of previous eventsReportingResearch Project GrantsResourcesSexual and Gender MinoritiesSiblingsSocial supportSolidSourceTestingTimeTranslational ResearchWorkYouthbasebehavior changebrief interventioncondomscontrol trialdesigneffective interventionexperiencefamily supportfollow-uphigh riskhigh risk menhigh risk populationimprovedmanmembermenmen who have sex with menpre-exposure prophylaxisracial and ethnicscale upsocial stigmasuccesssuccessful interventionuptakewillingness
项目摘要
Project Summary/Abstract
Despite the prevention and treatment efforts of the past 30 years, Latino men who have sex with men (MSM)
continue to be disproportionately impacted by HIV: diagnoses increased 14% between 2010-2014 and those
younger than 40 years old had the highest incidence rates. HIV biomedical interventions to reduce HIV
infections are not reaching Latino communities. Nearly 300,000 Latinos in the nation were eligible for HIV pre-
exposure prophylaxis (PrEP) in 2015, yet only 7,600 received a prescription for it.
Yet a powerful cultural source of motivation for behavior change has been underutilized: the family. Latinos
report a high reliance on family for material and emotional support and often choose healthy behaviors to “do
right” by their family. Yet no family-based interventions to promote PrEP have been tested among Latino MSM
at high-risk for HIV infection. Although Latino MSM often experience family rejection and stigma, studies show
that many continue to prioritize family support for behavior change over other sources of support; that strained
family ties are reestablished over time; and that Latino MSM and their siblings come to rely on each other as
they age. Siblings are often a lifelong source of social support and 77% of Latinos have at least one sibling.
This project aims to engage the siblings of Latino MSM in the development and delivery of PrEP-uptake
messages and to evaluate the initial efficacy of involving siblings in HIV biomedical interventions.
Specific Aims:
(1) To develop intervention messages to increase PrEP use in high-risk Latino MSM that can be
delivered by their siblings. We will use IMB model constructs to create these messages. We will conduct
in-depth interviews with 30 LMSM-Sibling pairs to identify factors relevant for the development and delivery of
messages to increase PrEP-use. Messages will be rated by a panel of experts and tested with 3 focus groups.
(2) To implement the intervention messages in an uncontrolled pilot study with Latino MSM and their
siblings (n=20 pairs). We will use a pre/post test design with 30-day follow-up with 20 Latino MSM-sibling
pairs to gather feasibility and acceptability data, and to refine messages and delivery procedures as needed.
(3) To conduct a two-group randomized control trial (n=124) to evaluate the efficacy of sibling-delivered
PrEP messages compared with provider-delivered standard PrEP messages for use with high-risk
Latino MSM.
An important aim of this project is to develop an effective and brief intervention that can be sustained by our
community partner and PrEP Center for Excellence, St. John’s Well Child and Family Center, and ultimately
scaled-up by health departments and other PrEP stakeholders. Future studies could adapt this approach for
other racial/ethnic sexual and gender minorities.
项目总结/摘要
尽管在过去30年的预防和治疗努力,拉丁美洲男子谁与男性发生性关系(MSM)
继续受到艾滋病毒的不成比例的影响:2010-2014年间,
40岁以下发病率最高。艾滋病毒生物医学干预措施,以减少艾滋病毒
感染没有到达拉丁裔社区。全国近30万拉丁美洲人有资格在艾滋病毒感染前
在2015年,只有7,600人获得了暴露预防(PrEP)的处方。
然而,行为改变的一个强大的文化动力来源却没有得到充分利用:家庭。拉丁裔
报告高度依赖家庭的物质和情感支持,并经常选择健康的行为“做
正确的”由他们的家人。然而,没有以家庭为基础的干预措施,以促进PrEP已在拉丁美洲男男性行为者中进行了测试
艾滋病感染的高危人群虽然拉丁裔男男性接触者经常经历家庭的排斥和耻辱,研究表明,
许多人继续优先考虑家庭对行为改变的支持,而不是其他支持来源;
随着时间的推移,家庭关系重新建立;拉丁裔男男性接触者和他们的兄弟姐妹相互依赖,
他们会变老兄弟姐妹通常是社会支持的终身来源,77%的拉丁美洲人至少有一个兄弟姐妹。
该项目旨在让拉丁裔男男性接触者的兄弟姐妹参与PrEP摄取的开发和交付
信息,并评估让兄弟姐妹参与艾滋病毒生物医学干预措施的初步效果。
具体目标:
(1)制定干预信息,以增加PrEP在高风险拉丁裔MSM中的使用,
由他们的兄弟姐妹传递。我们将使用IMB模型构造来创建这些消息。我们会进行
与30个LMSM兄弟姐妹对进行深入访谈,以确定与开发和交付相关的因素,
增加PrEP使用的信息。信息将由专家小组进行评级,并由3个焦点小组进行测试。
(2)在一项针对拉丁裔男男性行为者及其
兄弟姐妹(n=20对)。我们将使用前/后测试设计,对20名拉丁裔MSM兄弟姐妹进行30天随访
配对收集可行性和可接受性数据,并根据需要完善信息和传递程序。
(3)进行两组随机对照试验(n=124),以评价同胞分娩的疗效
PrEP消息与提供者提供的标准PrEP消息相比,用于高风险
拉丁裔男男性接触者
该项目的一个重要目标是开发一种有效和短暂的干预,可以通过我们的
社区合作伙伴和PrEP卓越中心,圣约翰儿童和家庭中心,并最终
卫生部门和其他PrEP利益攸关方扩大了规模。未来的研究可以采用这种方法,
其他种族/族裔性和性别少数群体。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Homero Erwin del Pino其他文献
Homero Erwin del Pino的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Homero Erwin del Pino', 18)}}的其他基金
Core E -Community Engagement and Clinical Informatics Core
核心电子社区参与和临床信息学核心
- 批准号:
10609767 - 财政年份:2022
- 资助金额:
$ 24.78万 - 项目类别:
Core E -Community Engagement and Clinical Informatics Core
核心电子社区参与和临床信息学核心
- 批准号:
10458374 - 财政年份:2022
- 资助金额:
$ 24.78万 - 项目类别:
Understanding and Engaging Families in HIV Biomedical Prevention for Latino Men Who Have Sex with Men
了解并让家庭参与针对男男性行为拉丁裔男性的艾滋病毒生物医学预防
- 批准号:
10311982 - 财政年份:2020
- 资助金额:
$ 24.78万 - 项目类别:
Understanding and Engaging Families in HIV Biomedical Prevention for Latino Men Who Have Sex with Men
了解并让家庭参与针对男男性行为拉丁裔男性的艾滋病毒生物医学预防
- 批准号:
10524046 - 财政年份:2020
- 资助金额:
$ 24.78万 - 项目类别:
Understanding and Engaging Families in HIV Biomedical Prevention for Latino Men Who Have Sex with Men
了解并让家庭参与针对男男性行为拉丁裔男性的艾滋病毒生物医学预防
- 批准号:
9926760 - 财政年份:2020
- 资助金额:
$ 24.78万 - 项目类别:
Understanding and Engaging Families in HIV Biomedical Prevention for Latino Men Who Have Sex with Men
了解并让家庭参与针对男男性行为拉丁裔男性的艾滋病毒生物医学预防
- 批准号:
10091513 - 财政年份:2020
- 资助金额:
$ 24.78万 - 项目类别:
Behavioral Research Project:Promoting HIV PrEP among MSM: a Randomized Controlled Trial Protocol
行为研究项目:在 MSM 中推广 HIV PrEP:随机对照试验方案
- 批准号:
10349526 - 财政年份:2009
- 资助金额:
$ 24.78万 - 项目类别:
Behavioral Research Project:Promoting HIV PrEP among MSM: a Randomized Controlled Trial Protocol
行为研究项目:在 MSM 中推广 HIV PrEP:随机对照试验方案
- 批准号:
10581689 - 财政年份:2009
- 资助金额:
$ 24.78万 - 项目类别:
相似国自然基金
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
- 批准号:JCZRQN202500010
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
- 批准号:2025JJ70209
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
- 批准号:
- 批准年份:2024
- 资助金额:0 万元
- 项目类别:面上项目
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
- 批准号:2023JJ50274
- 批准年份:2023
- 资助金额:0.0 万元
- 项目类别:省市级项目
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
- 批准号:
- 批准年份:2022
- 资助金额:33 万元
- 项目类别:地区科学基金项目
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
- 批准号:
- 批准年份:2022
- 资助金额:52 万元
- 项目类别:面上项目
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
- 批准号:n/a
- 批准年份:2022
- 资助金额:10.0 万元
- 项目类别:省市级项目
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
- 批准号:81973577
- 批准年份:2019
- 资助金额:55.0 万元
- 项目类别:面上项目
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
- 批准号:81602908
- 批准年份:2016
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
高血糖激活滑膜AGE-RAGE-PKC轴致骨关节炎易感的机制研究
- 批准号:81501928
- 批准年份:2015
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
相似海外基金
PROTEMO: Emotional Dynamics Of Protective Policies In An Age Of Insecurity
PROTEMO:不安全时代保护政策的情绪动态
- 批准号:
10108433 - 财政年份:2024
- 资助金额:
$ 24.78万 - 项目类别:
EU-Funded
The role of dietary and blood proteins in the prevention and development of major age-related diseases
膳食和血液蛋白在预防和发展主要与年龄相关的疾病中的作用
- 批准号:
MR/X032809/1 - 财政年份:2024
- 资助金额:
$ 24.78万 - 项目类别:
Fellowship
Atomic Anxiety in the New Nuclear Age: How Can Arms Control and Disarmament Reduce the Risk of Nuclear War?
新核时代的原子焦虑:军控与裁军如何降低核战争风险?
- 批准号:
MR/X034690/1 - 财政年份:2024
- 资助金额:
$ 24.78万 - 项目类别:
Fellowship
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341426 - 财政年份:2024
- 资助金额:
$ 24.78万 - 项目类别:
Continuing Grant
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341424 - 财政年份:2024
- 资助金额:
$ 24.78万 - 项目类别:
Continuing Grant
Walkability and health-related quality of life in Age-Friendly Cities (AFCs) across Japan and the Asia-Pacific
日本和亚太地区老年友好城市 (AFC) 的步行适宜性和与健康相关的生活质量
- 批准号:
24K13490 - 财政年份:2024
- 资助金额:
$ 24.78万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Discovering the (R)Evolution of EurAsian Steppe Metallurgy: Social and environmental impact of the Bronze Age steppes metal-driven economy
发现欧亚草原冶金的(R)演变:青铜时代草原金属驱动型经济的社会和环境影响
- 批准号:
EP/Z00022X/1 - 财政年份:2024
- 资助金额:
$ 24.78万 - 项目类别:
Research Grant
ICF: Neutrophils and cellular senescence: A vicious circle promoting age-related disease.
ICF:中性粒细胞和细胞衰老:促进与年龄相关疾病的恶性循环。
- 批准号:
MR/Y003365/1 - 财政年份:2024
- 资助金额:
$ 24.78万 - 项目类别:
Research Grant
Doctoral Dissertation Research: Effects of age of acquisition in emerging sign languages
博士论文研究:新兴手语习得年龄的影响
- 批准号:
2335955 - 财政年份:2024
- 资助金额:
$ 24.78万 - 项目类别:
Standard Grant
Shaping Competition in the Digital Age (SCiDA) - Principles, tools and institutions of digital regulation in the UK, Germany and the EU
塑造数字时代的竞争 (SCiDA) - 英国、德国和欧盟的数字监管原则、工具和机构
- 批准号:
AH/Y007549/1 - 财政年份:2024
- 资助金额:
$ 24.78万 - 项目类别:
Research Grant