Understanding and Engaging Families in HIV Biomedical Prevention for Latino Men Who Have Sex with Men

了解并让家庭参与针对男男性行为拉丁裔男性的艾滋病毒生物医学预防

• 批准号: 10091513
• 负责人: Homero Erwin del Pino
• 金额: $ 12.95万
• 依托单位: CHARLES R. DREW UNIVERSITY OF MED & SCI
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-29 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10091513
• 关键词: AIDS prevention; AIDS/HIV problem; Address; Adolescent; Affect; Award; Behavior; Biometry; Blood; Chicago; Cities; Clinic; Clinical Research; Cohort Studies; Color; Complex; Data; Data Analyses; Development; Effectiveness; Emotional; Ensure; Family; Family Relationship; Family member; Federally Qualified Health Center; Focus Groups; Funding; Goals; HIV; HIV Infections; HIV diagnosis; HIV/STD; Health; Heterosexuals; Homophobia; Human immunodeficiency virus test; Individual; Infrastructure; Intervention; Interview; Knowledge; Latino; Long-Term Effects; Longevity; Los Angeles; Marshal; Medicine; Mental Health; Mentors; Mentorship; Minority; Modeling; Motivation; National Institute of Drug Abuse; National Institute of Mental Health; Outcome; Paper; Perception; Pharmacy facility; Philosophy; Prevention; Procedures; Process; Prospective cohort study; Psyche structure; Public Health; Publishing; Reporting; Research; Research Personnel; Research Priority; Research Training; Resources; Risk; Risk Behaviors; Safe Sex; Science; Sex Behavior; Sexual and Gender Minorities; Siblings; Social support; Source; System; Testing; Time; Training; Translational Research; Universities; Urine; Viral; Viral Load result; Work; Youth; acceptability and feasibility; base; behavior change; career; career development; clinical center; clinical epidemiology; cohort; design; efficacy testing; epidemiology study; experience; family support; follow-up; health disparity; high risk; high risk men; men; men who have sex with men; mid-career faculty; minority communities; pre-exposure prophylaxis; prevent; prevention service; preventive intervention; public health research; racial and ethnic; recruit; social stigma; stem; substance use; therapy development; treatment services; uptake; willingness

Project Summary/Abstract Candidate: This K01 is submitted by Dr. del Pino, Associate Professor, from Charles R. Drew University of Medicine and Science (CDU). This proposal is the next step in his transition from philosophy to public health research. He seeks to reduce HIV disparities among Latino men who have sex with men (MSM) by analyzing family support data from three prospective cohort studies in Los Angeles and Chicago and by conducting formative research to leverage the siblings of Latino MSM in an HIV biomedical prevention intervention. He has published qualitative and quantitative papers on family support, substance use, and HIV. He is currently supported by the CDU Emerging Scholars Award and CRECD. Career Development and Training Plan: Dr. del Pino's mentoring team includes Dr. Steve Shoptaw (expert in substance use and biomedical interventions), Dr. Nina Harawa (expert in the development of culturally responsive HIV-prevention interventions for MSM of color), and Dr. Arun Karlamangla (expert in complex biostatistical data analysis and longitudinal clinical epidemiology research). The training goals (advanced biostatistics, families and stigma, and intervention development) will be achieved through coursework and individual tutorials with each mentor. He will have access to the UCLA CTSI (NCATS); UCLA CHIPTS (NIMH); and to AXIS, CDU's center for clinical and translational research resources and trainings (NIMHD). Research Plan: Despite the prevention and treatment efforts of the past 30 years, Latino MSM continue to be disproportionately impacted by HIV. Yet a powerful cultural source of motivation has been underutilized: the family. This project seeks to address HIV disparities by addressing gaps in our knowledge of (a) how family support affects the behaviors and health of Latino MSM over time and (b) how to engage siblings in the development and delivery of PrEP-use messages. Aim 1: Determine how family support and mental health affect the HIV-related behaviors (e.g., substance use, sexual risk) and HIV-related health (e.g., STI, HIV viral load) of Latino MSM over time. Hypothesis: Latino MSM with greater family support over time will report better HIV-related risk behaviors and health outcomes than Latino MSM who report little to no family support. Aim 2: Identify barriers and facilitators to engaging Latino MSM and siblings in HIV biomedical interventions. Aim 3: Develop and pilot test sibling-delivered messages to increase PrEP use in high-risk Latino MSM to gather feasibility and acceptability data and to refine the intervention processes and messages. Summary: The Career Development and Training Plan and the Research Plan will prepare Dr. del Pino to submit an R01 to test the efficacy and effectiveness of a culturally-specific, sibling-based intervention to reduce HIV disparities among Latino MSM. His mentorship team has the required expertise and established record of mentoring junior researchers to ensure that he becomes an independently-funded investigator.

项目摘要/摘要 候选人：本K01由德鲁大学副教授Del Pino博士提交 医学与科学(CDU)。这一提议是他从哲学向公共卫生过渡的下一步 研究。他试图通过分析男男性行为(MSM)中的拉丁裔男性之间的艾滋病毒差异来减少这种差异 来自洛杉矶和芝加哥三项前瞻性队列研究的家庭支持数据，并通过进行 在艾滋病毒生物医学预防干预中利用拉丁裔MSM兄弟姐妹的形成性研究。他有 发表了关于家庭支持、物质使用和艾滋病毒的定性和定量论文。他目前 由基民盟新兴学者奖和CRECD支持。 职业发展和培训计划：Del Pino博士的指导团队包括Steve Shoptaw博士(专家 物质使用和生物医学干预)，Nina Harawa博士(文化发展专家 有色人种男男性接触者的响应艾滋病毒预防干预)和Arun Karlamangla博士(复合体专家 生物统计数据分析和纵向临床流行病学研究)。培训目标(高级 生物统计学、家庭和耻辱以及干预发展)将通过课程和 与每位导师一起提供单独的教程。他将有权访问加州大学洛杉矶分校(NCATS)；加州大学洛杉矶分校(NIMH)； 以及CDU的临床和转化性研究资源和培训中心(NIMHD)。 研究计划：尽管过去30年进行了预防和治疗努力，拉丁裔MSM仍在继续 不成比例地受到艾滋病毒的影响。然而，激励的一个强大的文化来源一直没有得到充分利用： 一家人。这个项目试图通过解决我们对(A)家庭如何了解的差距来解决艾滋病毒的差异 随着时间的推移，支持会影响拉丁裔MSM的行为和健康，以及(B)如何让兄弟姐妹参与 PrEP-Use报文的开发和交付。 目标1：确定家庭支持和心理健康如何影响艾滋病毒相关行为(例如，药物使用、 随着时间的推移，拉丁裔男男性接触者的性行为风险)和与艾滋病毒相关的健康(例如性传播感染、艾滋病毒病毒载量)。假设：拉丁裔MSM 随着时间的推移，有更多的家庭支持将报告更好的艾滋病毒相关危险行为和健康结果 报告很少或根本没有家庭支持的拉丁裔MSM。目标2：确定与拉美裔接触的障碍和促进者 男男性接触者和兄弟姐妹在艾滋病毒生物医学干预中的作用。目标3：开发并测试兄弟姐妹传递的消息以 在高危拉丁裔MSM中增加PrEP的使用，以收集可行性和可接受性数据，并完善 干预流程和信息。 摘要：职业发展和培训计划和研究计划将使德尔·皮诺博士做好准备 提交R01以测试特定文化、以兄弟姐妹为基础的干预措施的有效性和有效性，以减少 拉丁裔男男性接触者之间的艾滋病毒差异。他的指导团队拥有所需的专业知识，并建立了 指导初级研究人员，确保他成为一名独立资助的研究人员。