A Wearable Magnetocardiography Imaging System

项目摘要 最近的研究表明，放射治疗（RT）消融是一个非常有前途的替代方案 无法接受导管消融术的药物难治性室性心动过速患者的治疗。 理想情况下，RT消融与非侵入性电生理（EP）成像结合进行， 例如ECG成像（ECGI），使得整个过程是非侵入性的;然而，目前， 非侵入性EP成像比RT准确性低得多，需要显著改进， 实现RT消融的全部潜力。 在这个项目中，我们提出利用心磁图（MCG）来开发MCG成像 （MCGI）系统。与ECG相比，MCG提供了源 由于磁信号的有利传输特性，从 从实用的角度来看，MCG更方便，因为它是一种非接触式技术，而ECGI 需要应用大的电极阵列。拟议的系统将基于一个 一种革命性的磁传感器，称为光泵磁力计（OPM）， 是由我们公司首先推向市场的。OPM比SQUID实用得多 磁力计，因为它们更小，更便宜，并在室温下工作。这 将能够构建具有覆盖整个躯干的共形传感器阵列的MCGI系统。 总体目标是构建一个MCGI系统，与传统的MCGI系统相比， 当前ECGI/MCGI系统。第一阶段的目标是：1）确定最佳传感器 基于信号的空间特性的分析的MCGI系统的配置，2）设计 一个紧凑的磁屏蔽，是病人友好，并最大限度地减少空间的要求， 系统，3）设计一个快速，准确的传感器位置数字化的策略，以及4） 在一个正常的小型研究中证明所提出的技术的关键方面的可行性， 科目

PROJECT SUMMARY Recent studies have shown radiation therapy (RT) ablation to be a highly promising alternative therapy for patients with drug-refractory VT who are unable to undergo catheter-based ablation. Ideally, RT ablation is performed in conjunction with noninvasive electrophysiology (EP) imaging, such as ECG imaging (ECGI), so that the entire procedure is noninvasive; however, currently noninvasive EP imaging is much less accurate than RT and needs to be significantly improved to realize the full potential of RT ablation. In this project, we propose to utilize magnetocardiography (MCG) to develop an MCG imaging (MCGI) system. In comparison to ECG, MCG provides fundamental advantages for source localization and imaging due to the favorable transmission properties of magnetic signals. From a practical standpoint, MCG is more convenient because it is a contactless technique, whereas ECGI requires application of a large array of electrodes. The proposed system will be based on a revolutionary type of magnetic sensor, known as an optically-pumped magnetometer (OPM), which was first brought to market by our company. OPMs are far more practical than SQUID magnetometers because they are smaller, less expensive, and operate at room temperature. This will enable construction of an MCGI system with a conformal sensor array that covers the entire torso. The overall goal is to construct an MCGI system with improved accuracy and ease-of-use, compared to current ECGI/MCGI systems. The Phase I aims are to 1) determine an optimal sensor configuration for the MCGI system based on analysis of the spatial properties of the signal, 2) design a compact magnetic shield that is patient-friendly and minimizes the space requirements of the system, 3) devise a strategy for rapid, accurate digitization of the sensor locations, and 4) demonstrate the feasibility of key aspects of the proposed techniques in a small study of normal subjects.