Adjustable Helmet Array for Neonatal Magnetoencephalography

用于新生儿脑磁图的可调头盔阵列

• 批准号: 8393565
• 负责人: Vishal K Shah
• 金额: $ 19.76万
• 依托单位: QUSPIN
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-21 至 2013-05-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8393565
• 关键词: Adopted; Area; Auditory Evoked Potentials; Brain; Caliber; Consumption; Development; Diagnosis; Dimensions; Environment; Functional Imaging; Functional disorder; Goals; Head; Helmet; Imaging Techniques; Infant; Institutes; Length; Magnetism; Magnetoencephalography; Measurement; Measures; Mental Retardation; Metals; Modeling; Neonatal; Neuraxis; Neurodevelopmental Disorder; Neurosciences; Noise; Patients; Phase; Positioning Attribute; Relaxation; Research; Research Personnel; Resolution; Scalp structure; Shapes; Signal Transduction; Speed; Subject Headings; System; Techniques; Technology; Universities; Validation; base; cost; design; digital; experience; flexibility; human subject; innovation; instrumentation; magnetic field; meetings; neurodevelopment; new technology; novel; outcome forecast; patient safety; postnatal; prototype; sensor; spatiotemporal

DESCRIPTION (provided by applicant): The goal of this project is to develop a very low-cost whole-head neonatal MEG system that can adapt to the shape and size of the head. Clinically, there is a longstanding need for a technology that can aid in the diagnosis and prognosis of babies with brain dysfunction due to intrauterine and postnatal central nervous system insults, which may result in mental retardation and neurodevelopmental disorders. The proposed system is completely non-invasive and is based on a recent breakthrough in atomic magnetometer technology that eliminates majority of the costs and complexity associated with superconducting sensors used in traditional MEG systems. PUBLIC HEALTH RELEVANCE: MEG is one of the most promising functional imaging techniques that have been applied to neonatal and infant studies. The goal of this project is to develop a MEG system that is ideally suited for infant studies and costs less by almost an order of magnitude - $200k to $300k compared to >$2M for a SQUID-based system. We expect that successful execution of this project will stimulate research in neonatal and infant MEG and encourage many more researchers and clinicians to adopt MEG technology.

描述（由申请人提供）：该项目的目的是开发一个非常低成本的全头新生儿MEG系统，该系统可以适应头部的形状和大小。从临床上讲，长期以来需要通过宫内和产后中枢神经系统损害导致的脑功能障碍的婴儿的诊断和预后的技术，这可能导致智力低下和神经发育障碍。所提出的系统是完全非侵入性的，是基于最新的原子磁力计技术突破，该技术消除了与传统MEG系统中使用的超导传感器相关的大多数成本和复杂性。 公共卫生相关性：MEG是已应用于新生儿和婴儿研究的最有希望的功能成像技术之一。该项目的目的是开发一个非常适合婴儿研究的MEG系统，几乎降低了一个数量级的成本 - $ 20万至30万美元，而基于鱿鱼的系统则> 200万美元。我们预计该项目的成功执行将刺激新生儿和婴儿MEG的研究，并鼓励更多的研究人员和临床医生采用MEG技术。

项目成果

A new generation of magnetoencephalography: Room temperature measurements using optically-pumped magnetometers.

• DOI: 10.1016/j.neuroimage.2017.01.034
• 发表时间: 2017-04-01
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Boto E;Meyer SS;Shah V;Alem O;Knappe S;Kruger P;Fromhold TM;Lim M;Glover PM;Morris PG;Bowtell R;Barnes GR;Brookes MJ
• 通讯作者: Brookes MJ