AUDITORY ASSESSMENT WITH AEPS IN CHILDREN

这项研究的总体目标是提高诊断， 听力损失和中枢性听觉缺陷。 使用 某些听觉诱发电位（AEP），包括中潜伏期 (MLR)和迟发性电位，在儿科人群中受到限制 由于睡眠期间这些反应的可变性， 反应对行为任务的依赖性可能超出了 一个小孩子的能力。 这个项目是一个调查的 儿童MLR和失配负波（MMN）AEP，并说明如何 这些限制是可以克服的。 第一个主要目标是开发一种方法来确定期间 睡眠有利于记录MLR。 先前的研究 表明某些睡眠阶段比其他阶段更有利， 它们可以通过分析特定的EEG来区分， 振幅和频率特性。 建议进行一项调查 “三角洲比率”的效用，三角洲占主导地位的衡量标准 EEG中的活动。 δ存在/不存在的在线检测可以 当孩子处于有利的MLR时，向临床医生或研究人员发出信号 记录期间。 类似的措施最终可能适用于其他国家。 AEP。 第二个主要目标是描述MMN响应于定义明确的 言语刺激，以确定该反应是否可以提供客观的 学龄儿童听觉辨别力的神经生理学测量 孩子 MMN反映了小声学信号的中枢听觉处理过程 差异，不取决于孩子的积极参与。 MMN将由不同的合成语音刺激引起， 这些声学参数是语音感知的基础。 另一 目的是确定MLR的发育变化， MMN与发育行为测量相关， 通过标准化的心理能力和过程的测量， 学习和学术成就。 临床适用性 将在（1）中评价联合电生理/行为方法 行为识别中枢听觉缺陷的儿童和（2） 注意力缺陷多动障碍的儿童--一组 听觉加工缺陷的共存是好的 确立了习

The overall goal of this investigation is to improve the diagnosis of hearing loss and central auditory deficits in young children. The use of certain auditory evoked potentials (AEPs), including middle latency (MLR) and late potentials, has been limited in pediatric populations because of the variability of these responses during sleep or the dependence of the responses on a behavioral task which may be beyond the capabilities of a young child. This project is an investigation of the MLR and mismatch negativity (MMN) AEPs in children and addresses how these limitations may be overcome. The first major aim is to develop a means to identify the periods during sleep that are favorable for recording the MLR. Previous research has indicated that certain sleep stages are more favorable than others and that they may be distinguished by analyzing the EEG for specific amplitude and frequency characteristics. Proposed is an investigation of the utility of the "delta ratio", a measure of the dominance of delta activity in the EEG. On-line detection of delta presence/absence could signal a clinician or researcher when a child is in a favorable MLR recording period. Similar measures could eventually be applied to other AEPs. A second major aim is to characterize the MMN in response to well-defined speech stimuli to determine if this response can provide an objective neurophysiologic measure of auditory discrimination in school-aged children. The MMN reflects central auditory processing of small acoustic differences and does not depend on active participation from the child. The MMN will be elicited by synthesized speech stimuli that differ in acoustic parameters that are fundamental to speech perception. Another objective is to determine whether developmental changes in the MLR and the MMN correlate with behavioral measures of development as determined by standardized measures of mental aptitude and processes underlying learning and academic achievement. Clinical applicability of the combined electrophysiologic/behavioral approach will be evaluated in (1) children with behaviorally identified central auditory deficits and (2) children with attention deficit hyperactivity disorder -- a group in which the co-existence of auditory processing deficits is well established.